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Edited By
A.G. Lee, Department of Biochemistry, University of Southampton, Southampton, England
Included in series
Biomembranes. A Multi-Volume Treatise,
Description
Volume 4 of Biomembranes covers endocytosis, exocytosis and related processes. A major role of the plasma membrane is as a permeability
barrier, keeping the inside of the cell inside and the outside, outside. Mechanisms must then exist to allow movement of material between
the cell and its environment. One mechanism for export from the cell is by exocytosis, a process in which the membranes of secretory
vesicles fuse with the plasma membrane releasing the contents of the vesicle into the extracellular medium. The process has been studied
in particular depth for the release of neurotransmitters at the synapse. Import into the cell is possible by the process of receptor-mediated
endocytosis in which selected plasma membrane proteins are internalizes; when these proteins are receptors for macromolecules, the result
is uptake of the macromolecule. Transferring, the low-density lipoprotein, and asialoglycoproteins are all taken up into cells in this
way. Phagocytosis, the ingestion of cells and cell fragments by neutrophils and macrophages, also involves receptors - on the phagocytic
membrane - of which the best studied are those for the Fc domain of IgG, for the third component of complement, and for the mannose/fructose
carbohydrates. Protection of a host against infection can also be achieved by damaging the integrity of the plasma membrane of the invading
organism. This is the strategy evolved by the cytotoxic T lymphocytes, which produce a pore-forming toxin, perforin. Volume 4 of Biomembranes
explores the structures and mechanisms involved in these biologically and medically important processes.
Contents
Contents. List of Contributors. Preface (A.G. Lee). Receptor-Mediated Endocytosis (A.P. jackson, H.D. Blackbourn, S.F.C. Hawkins, and
M.J.G. Hughes). Phagocytosis (E.J. Brown and T.H. Steinberg). Annexin Hypothesis for Exocytosis (A.L. Burns and H.B. Pollard). Small
Synaptic Vesicles (N.V.L. Hayes and A.J. Baines). Membrane Attack by Complement: Assembly and Biology of Terminal Complement Complexes
(M.L. Shin, H.G. Rus, and F.I. Niculescu). Cell Membrane Damage in Lymphocyte-Mediated Cytolysis: Role of Lymphocyte Pore-Forming Protein
Perforin (C. Liu, P.M. Persechini, M.F. Horta, and J.D.E. Young). The Asialoglycoprotein Receptor (C. Fuhrer and M. Spiess). The Low
Density Lipoprotein Receptor (A. Ozinsky, G.A. Coetzee, and D.R. van der Westhuyzen). Mannose-6-Phophate Receptors (R. Pohlmann). The
Transferrin Receptor (C.A. Enns, E.A. Rutledge, and A.M. Williams). Index.
| Bibliographic details |
Hardbound, 0 pages, publication date: DEC-1996
ISBN-13: 978-1-55938-661-6
ISBN-10: 1-55938-661-4
Imprint: ELSEVIER
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Last update: 12 Jun 2009
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