Description Viruses are the agent responsible for perhaps up to one million cases of cancer worldwide each year. Significantly, the study of viruses
has also provided important clues to the causes and development of the most common human cancers. This volume presents an account of
those viruses which have been directly associated with common human malignancies such as human papillomavirus (HPV), cervical carcinoma,
Epstein-Barr virus (EBV) and Burkitt's lymphoma. In addition, the biology and biochemistry of those viruses which have been shown to
be capable of transforming cells in culture are described in detail. Thus adenovirus are discussed, as are the other small DNA tumour
viruses - Simian virus 40 (SV40) and polyoma virus. Consideration has also been given to human T-cell leukaemia virus (HTLV), hepatitis
B virus (HBV) and human herpes virus 8 (HHV8), amongst others. General themes such as the host's immune response to viral infection,
virally-induced apoptosis and the use of viruses as a delivery system in gene therapy have been discussed.
Individual chapters have
been written by an international group of experts in their own field of research.
Contents Introduction.
Immortalization of primary rodent cells by SV40 (A. J. Darmon, P. Jat).
Adenovirus early region 1 proteins - action
through interaction (R. Grand).
Polyoma virus middle T-antigen: growth factor receptor mimic (P.R. Nicholson, S.M. Dilworth).
Pathobiology
of human papillomaviruses (M. Stanley).
The function of the human papillomavirus oncogenes (D. Pim, M. Thomas, L. Banks).
Hepatitis
B virus in experimental carcinogenesis studies (S. Schaefer).
Epstein-Barr virus and oncogenesis: from tumors to transforming genes
(L. Young).
Human Herpes virus 8 (R. Jarrett).
Human Herpes virus γ-deregulation of cell growth and apoptosis (F. Neipel, E.
Meinl).
Human T-cell leukemia virus type 1 oncoprotein, Tax: Cell cycle dysregulation and cellular transformation (K.G. Low, Kuan-The
Jeang).
Proviral taggin a strategy using retroviruses to identify oncogenes (T. Möröy, M. Zörnig, T. Schmidt).
Viruses
and apoptosis (E. Hammond, R. Grand).
Evasion of the immune system by tumour viruses (E. Blair, N. Phillpot).
Immunity to human papilloma
viruses: implications for vaccine design (J. Steele).
Recombinant adenoviruses in cancer therapy (M. Powell, G. Wilkinson).
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