Handbook of Clinical Neurology (Series Editors: Aminoff, Boller and Swaab) To order this title, and for more information, click here
Edited By Charles Duyckaerts, Lab de Neuropath R Escourolle, Paris, France Irene Litvan, Raymond Lee Lebby Professor of Parkinson Disease Research, Department of Neurology, University of Louisville School of Medicine, Louisville, KY, USA
Description This volume in the HANDBOOK OF CLINICAL NEUROLOGY (Series Editors: Michael J. Aminoff, Department of Neurology, University of California,
San Francisco, USA; Francois Boller, Bethesda, USA; Dick F. Swaab, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands)
deals with neuropathology, physiopathology, biology, clinics, and imaging of all or most dementing disorders that are presently known.
It also includes chapters on the legal and ethical issues to give the health care worker a general view on diseases that are not only
scientific riddles, but also the cause of affliction of many patients and of their families. Recently several major new advances in understanding
have been made and are covered in this volume (for example the progranulin mutation and the role of TDP-43). All those dealing with dementia,
at whatever level of expertise, may find this volume of value.
Contents
Section 1: General aspects:
History of dementia. Neuropsychological examination in dementia. Executive dysfunction
and neuropsychological testing. Neuropsychiatric evaluation in dementia. Electrophysiological evaluation of dementia. Feature extraction
and strategy of analyzing structural neuroimaging in dementia. Strategies for using molecular neuroimaging in dementia. Quality of life
in dementias. Diagnosis and management of caregiver burden in dementia. The memory disorders clinic. Legal aspects of dementia. Ethical
issues in the care of the patient with dementia. Economical aspects of dementia. Neuropathologic classification of dementias: introduction.
Tau, a biological marker of neurodegenerative diseases. Biologic models of neurodegenerative disorders. The relationship between nosology,
etiology and pathogenesis in neurodegenerative diseases.
Section 2: Specific disorders:
Alzheimer's
disease:
Alzheimer's disease: epidemiology. Clinical symptoms in Alzheimer's disease. Mild cognitive impairment. The
genetics of Alzheimer's disease. Neuropathology of Alzheimer's disease. Biochemistry and molecular biology of amyloid -protein and the
mechanism of Alzheimer's disease. Biological CSF Markers of Alzheimer!|s disease. Symptomatic therapeutic aspects in Alzheimer's disease.
Perspectives of Alzheimer's disease treatments. Biological transgenic mouse models of Alzheimer's disease.
Lewy body
diseases:
Clinical aspects of Parkinson dementia. Clinical aspects of dementia with Lewy bodies. The genetics and molecular
biology of alpha-synuclein. Neuropathology of dementia with Lewy bodies.
Frontotemporal dementias:
Epidemiological
aspects of frontotemporal dementia. Frontemporal lobar degeneration: clinical and pathologic overview. Clinical aspects of hereditary
frontotemporal dementia. Clinical aspects of TDP-43 proteinopathy, neurofilament inclusion body disease and dementias lacking distinctive
proteinopathy. The genetics of frontotemporal dementia. Neuropathology of hereditary forms of frontotemporal dementia and parkinsonismNeuropathology
of Pick body disease. Dementia and motor neuron disease. Neuronal intermediate filament inclusion disease. Biological models in frontotemporal
dementias.
Progressive supranuclear palsy :
The epidemiology of progressive supranuclear palsy. Clinical
aspects of progressive supranuclear palsy. Genetics of progressive supranuclear palsy. Neuropathology of progressive supranuclear palsy.
Current and future therapeutic approaches in progressive supranuclear palsy.
Corticobasal degeneration:
Corticobasal
degeneration: clinical aspects. Neuropathology and genetics of corticobasal degeneration. Current and future management of the corticobasal
syndrome and corticobasal degeneration.
Agyrophilic grains
Clinical aspects of dementia with argyrophilic
grains. Argyrophilic grain disease.
Hippocampal sclerosis:
Clinical aspects of hippocampal sclerosis.
Neuropathology of hippocampal sclerosis.
Primary progressive aphasias:
Primary progressive aphasia and
kindred disorders.
Huntington!|s disease:
Pre-symptomatic Huntington's disease. Neuropathology of Huntington's
disease. The biology of Huntington's disease. Therapeutic approach in Huntington's disease.
Vascular dementias:
The
epidemiology of vascular dementia. Clinical and therapeutic aspects of vascular dementia. Cerebral autosomal dominant arteriopathy with
subcortical infarcts and leukoencephalopathy . The neuropathology of vascular and mixed dementia and vascular cognitive impairment.
Demyelinating
disorders:
Understanding and managing cognitive dysfunction in multiple sclerosis. Neuropathology of cognitive dysfunction
in multiple sclerosis. Leukodystrophies: clinical and therapeutic aspects.
Transmissable diseases
Clinical
and therapeutic aspects of prion disease. Clinical aspects of variant Creutzfeldt-Jakob disease. Biology and neuropathology of prion
diseases. Human immunodeficiency virus-associated dementia: clinical aspects, biology, and treatment. Neuropathology and HIV dementia.
Clinical and therapeutic aspects of dementia in syphilis and Lyme disease. Biology and neuropathology of dementia in syphilis and Lyme
disease.
Toxic diseases:
Epidemiology of alcohol-related dementia. Toxic dementias. Neuropathology of
alcohol-related cognitive alterations.
Cancer:
Paraneoplastic disorders of the memory and cognition:
clinical aspects and therapeutic approaches. Brain tumors and dementia.
Hydrocephalus:
Clinical aspects
and biology of normal pressure hydrocephalus.
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