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 | HYPOTHALAMIC INTEGRATION OF ENERGY METABOLISM, 153
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Edited By
A. Kalsbeek, The Netherlands Institute for Brain Research, Amsterdam, The Netherlands
Eric Fliers, The Netherlands Institute for Brain Research, Amsterdam, The Netherlands
Michel Hofman, The Netherlands Institute for Brain Research, Amsterdam, The Netherlands
D.F. Swaab, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands
E.J.W. Van Someren, The Netherlands Institute for Brain Research, Amsterdam, The Netherlands
R.M. Buijs, Netherlands Institute for Brain Research, Meibergdreef 33, 1105 AZ, Amsterdam, The Netherlands
Included in series
Progress in Brain Research, 153
Description
The prevalence of obesity in developed countries is fast becoming a health issue on par with infectious diseases and malnutrition. Research
in this area has grown substantially and includes the neurochemical pathways of the hypothalamus and its role in regulating energy expenditures
in the body. This volume in the Progress in Brain Research series examines the emerging role of the hypothalamus as
a crucial link between the sensing of nutrients and the control of insulin sensitivity, glucose uptake, and glucose production, the integrative
role of the hypothalamus in thyroid and bone metabolism, the interaction between circadian information and energy metabolism, and the
important interplay between the immune system and energy metabolism.
Audience
Neuroscientists, endocrinologists, and obesity researchers.
Contents
List of Contributors.
Preface.
Acknowledgements.
I. HYPOTHALAMIC INTEGRATION OF ENERGY METABOLISM
1. The human hypothalamus in metabolic
and episodic disorders.
2. Synaptic plasticity mediating Leptin's effect on metabolism.
3. The hypothalamus, hormones and hunger: alterations
in human obesity and illness.
4. Glucocorticoids, chronic stress, and obesity.
5. Design and synthesis of (ant)-antagonists that alter
appetite and adiposity.
6. Monogenic human obesity syndromes.
II. HYPOTHAMAMIC INTEGRATION OF BLOOD BORNE SIGNALS
7. The selfish brain:
competition for energy resources.
8. Integration of metabolic stimuli in the hypothalamic arcuate nucleus.
9. Adipokines that link obesity
and diabetes to the hypothalamus.
III. HYPOTHALAMIC CONTROL OF BONE AND THYROID METABOLISM
10. The circadian modulation of Leptin-controlled
bone formation.
11. Hypothalamic thyroid hormone feedback in health and disease.
12. The TRH Neuron: a hypothalamic integrator of energy
metabolism.
IV. RHYTHMS, SLEEP AND ENERGY METABOLISM
13. The seventeenth C.U. Ariens Kappers Lecture. An Introduction.
14. Staying awake
for dinner: hypothalamic integration of sleep, feeding and circadian rhythms.
15. Circadian timing in health and disease.
16. Circadian
time keeping: the daily ups and downs of genes, cells and organisms.
17. The hypothalamic clock and its control of glucose homeostatis.
18. Mechanisms and functions of coupling between sleep and temperature rhythms.
19. What can we learn from seasonal animals about the
regulation of energy balance?
V. HYPOTHALAMIC INTEGRATION OF "SENSORY" INFORMATION
20. Organization of circadian functions: interaction
with the body.
21. Hypoglycemia in diabetes: pathophysiological mechanisms and diurnal variation.
22. Hypothalamic integration of immune
function and metabolism.
Subject Index.
| Bibliographic details |
Hardbound, 430 pages, publication date: AUG-2006
ISBN-13: 978-0-444-52261-0
ISBN-10: 0-444-52261-1
Imprint: ELSEVIER
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| Price and Ordering |
Price:
GBP 151.99 USD 250 EUR 178.95
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Last update: 3 Oct 2009
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