Description Volume 45 of Advances in Enzyme Regulation is the proceedings of the 45th International Synthesis in Normal and Neoplastic
Tissues held at Indiana University School of Medicine Indianapolis, Indiana September 27-28, 2004.
Volume 45 concentrates on subjects
which have reached the stage of productive summarizaiton and critical evaluation in the light of extensive new results. This book also
lives up to its goal of advancing a few steps ahead of the general front of mammalian enzymic and metabolic regulation studies.
Contents Acknowledgments
List of participants
SESSION I NUCLEAR CONTROL
Implications for Nuclear Organization and Gene Transcription of Lamin
A/C Specific Mutations.
Spatio-Temporal Dynamics of Genomic Organization and Function in the Mammalian Cell Nucleus
SESSION II METABOLIC
DESIGN AND REGULATION
Metabolic Design Principles: Chemical and Physical Determinants of Cell Chemistry.
Down-regulation of Increased
Signal Transduction in Human Cancer Cells.
SESSION III RAS AND REGULATION
Ras Initiates Phosphatidyl-Inositol-3-Kinase(P13K)/PKB Mediated
Signalling Pathways in Untransformed Human Peripheral Blood T Lymphocytes.
Functional Analysis and Secondary Espression Profiling of
Candidate Genes Deregulated in Conjunction with Oncogenic Ras Signaling
SESSION IV CONTROLS AND APOPTOSIS
Induction of Apoptosis in
p53-Deficient L1210 Cells by an I KAPPA Beta Alpha Inhibitor (Bay 11-7085) via a NF KAPPA-Beta-Independent Mechanism.
Regulation of Gene
and Protein Expression in Cardiac Myocyte Hypertrophy and Apoptosis.
SESSION V REGULATION OF KEY ENZYMES
Peptide Inhibitors of Mammalian
Ribonucleotide Reductase.
SESSION VI NUCLEAR FUNCTION AND HUMAN NEOPLASIA
Nuclear Phospholipase C Beta1, Regulation of the Cell Cycle
and Progression of Acute Myeloid Leukemia.
Combinatorial Organization of the Transcriptional Regulatory Machinery in Biological Control
and Cancer.
SESSION VII EVOLUTIONARY CONSERVED SIGNAL PATHWAYS
Phosphatidylinositol Transfer Protein Function in the Yeast Saccharomyces
cerevisiae.
Modification of Protein Sub-Nuclear Location by Synthetic Phosphoinositides: Evidence for Nuclear Phosphoinositide Signaling
Mechamisms.
SESSION VIII SIGNAL TRANSDUCTION AND STRUCTURAL IMPACT
Role of Signal Transduction and Actin in G1 Phase Progression.
Emerging
Roles of Phosphatidylinositol Monophosphates in Cellular Signaling and Trafficking.
SESSION IX SIGNAL TRANSDUCTION
Human Guanylate Binding
Protein-1 (hGBP-1) Characterizes and Establishes a Non-Angiogenic Endothelial Cell Activation Phenotype in Inflammatory Diseases.
SESSION
X SPECIAL SYMPOSIUM LECTURE: H.L. PEARCE
The Evolution of Cancer Research and Drug Discovery at Lilly Research Laboratories.
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