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Robert Lazzarini, The Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, New York, NY, U.S.A.
Description With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage
has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin
repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular
and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into
disease mechanisms. This book represents a unique research reference on myelin biology and will serve as the definitive resource for
both the professional clinical and basic scientist.
Audience
Neurologists, neurobiologists, and cell biologists.
Contents Section I: Diseases of Myelin
Leukodystrophies: Overview and Classification
Multiple Sclerosis: Classification and Overview
Genetic Susceptibility
and Epidemiology
Cellular Damage and Repair in MS
MRI Visualization of MS
Multiple Sclerosis (General Clinical and Trials)
Adrenoleukodystrophies
Krabbe's Disease
Alexander's Disease
Pelizeaus-Merzbacher Disease
Guillain Barre Syndrome
Charcot-Marie-Tooth Disease
Infectious Demyelinating
Diseases
Ischemic White Matter Damage
Protein Misfolding as a Disease Determinant
Section II: Animals Models of Human Disease
Experimental
Allergic Encephalomyelitis
Experimental Models of Virus Induced Demyelination
Model's of Krabbe's Disease
Model's of Alexander's Disease
Model's of Pelizeaus Merzbacher Disease
Models of Charcot-Marie-Tooth Disease
Section III: The Myelin Genes and Products
Myelin Basic
Protein Gene
Proteolipid Protein Gene
Myelin Associated Glycoprotein Gene
Myelin Oligodendrocyte Glycoprotein Gene
Cyclic Nucleotide
Phosophohydrolase Gene
P0 Protein Gene
PMP 22 Gene
The Claudin 11 Gene
The Neurexin Gene
The Connexin 32 Gene
The Integrin Genes
The
Periaxin Gene
The QK1 Gene
Section IV: Glial Cell Development
Invertebrate Glia
Neural Cell Specification During Development
Progenitor
Cells of the Adult Human White Matter
Oligodendrocyte Lineage
Astrocyte Lineage
Schwann Cell Development
Olfactory Ensheathing Cells
Section V: Glial Cell and Myelin Functional Biology
Structure of the Myelinated Axon
Cell Biology of Myelin Assembly
The Transport and
Assembly of Myelin Lipids
Functional Organization of the Nodes of Ranvier
Electrophysiologic Consequences of Myelination
Remyelination
Through Engraftment
Remyelination by Endogenous Glia
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