Edited by
O.P. Ottersen, Dept. of Anatomy, Institute of Basic Medical Sciences, University of Oslo, POB 1105 Blindern, N-0317 Oslo, Norway
I.A. Langmoen, Dept. of Neurosurgery, The National Hospital, Rikshospitalet, N-0027 Oslo, Norway
L. Gjerstad, Nevrologisk avdeling, Rikshospitalet, N-0027 Oslo, Norway
Description
This volume provides a comprehensive update on basic glutamate research, from a clinical perspective. Thus, emphasis is placed on how
the different molecular players at the glutamate synapse interact to produce a postsynaptic response, how synaptic transmission is perturbed
in epilepsy and other pathological conditions, and how glutamate may acquire toxic properties and lead to acute or chronic neurodegeneration.
Promising targets for therapeutic strategies are discussed.
A coherent picture is provided of the glutamate synapse and its molecular
organization. The book therefore deals with each step in the signal process, from synthesis and vesicular uptake of glutamate to its
clearance following receptor activation.
Included in series
Progress in Brain Research
