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| ADVANCES IN VIRUS RESEARCH, 76
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To order this title, and for more information, click here
Karl Maramorosch
Aaron Shatkin, Center for Advanced Biotechnology and Medicine, Piscataway, NJ, USA
F.H. Murphy
Included in series
Advances in Virus Research,
Audience
Virologists, microbiologists, infectious diseases and public health specialists.
Contents
Introduction
Viral Hemorhagic fevers: The Global Problem - F.A. Murphy, U.C. Davis
What are the factors in emergence and what should
we expect in the next decade and later? 40 pp
Phylogeny of HFV?s - Stuart Nichol, CDC
What have phylogenetic studies done to help in
outbreak control, understanding the natural history, and in understanding emergence of VHF?
Rodent reservoirs of arenaviruses and
hantaviruses - Jim Mills, CDC
What are the evolving patterns of host ?virus interaction? What determines prevalence of rodent infection
and human risk? Are there refugia? Are there ecological generalizations that we can make?
Consequences of Endothelial Infections
- Sherif Zaki, CDC
What is the role of endothelial infection in VHF? In which VHF has it been identified? How does it bring about pathogenesis?
How does this contrast and interact with macrophage infection?
Important unresolved issues in VHF - Buchmeier, Peters
Need for antivirals
in Ebola. Understanding of genetic changes in emergence (filos, particularly). Understanding of natural cycle (filos, particularly).
Reverse genetics and innate immune responses to arenas.
Filoviruses
Recent Clinical, epidemiological, nosocomial transmission observations
on filoviruses - Dan Bausch and Scott Dowell
What is the overall picture of transmission and risk factors? Contrast with ongoing problems
such as HIV, plague, SARS. What did we learn from the intensive studies of 1995? What have we learned from the recent Marburg and Ebola-Sudan
outbreaks? Clinical picture, therapy, nosocomial transmission. What is the risk of nosocomial infection and what are the precautions
that can prevent it in the African setting?
Pathogenesis, vaccines - Gary Nabel
What are the roles of different viral proteins in
protection and pathogenesis? What is needed in terms of a protective vaccine? In light of above, what is the response elicited by adenovirus
vaccine and how does it predict protection? How would vaccines be tested and used in humans?
Cytokine Responses - Eric Leroi
What
do these mean in terms of pathogenesis? What are the data on humans and non-human primates and how do they fit together?
Virulence
Factors - Yoshi Kawaoka and Heinz Feldmann
How do these viruses make you sick and how do they suppress or escape the primate immune system?
How do they evade making a neutralizing antibody response? How does the recent VSV based vaccine illuminate this?
Lessons from macaque
pathogenesis - Geisbert, Jahrling
How does such a model contribute uniquely to our understanding? What are some of the big lessons –
eg, apoptosis of lymphocytes, DIC, early endothelial involvement, antithrombin Rx. Be synoptic and synthetic.
What are the insights
from the mouse model for Ebola? - Mike Bray, NIAID
Utilization of the model for screening. Unique insights from having murine immune
system reagents. What are the limitations?
Arenaviruses
Virology and immunology of arenaviral HF - Michael Buchmeier
Musings over
epitopes.
South American hemorhagic fevers - Delia Enria, Robt. Tesh
What are the new epidemiological findings? Control? Understanding
of pathogenesis?
| Bibliographic details |
Hardbound, 500 pages, publication date: SEP-2010
ISBN-13: 978-0-12-374525-5
Imprint: ACADEMIC PRESS
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Last update: 30 Nov 2009
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