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| HEMATOPOIETIC STEM CELL TRANSPLANTATION IN CLINICAL PRACTICE
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By
Jennifer Treleaven, MD, FRCP, FRCPath, Consultant Haematologist, Royal Marsden Hospital, Sutton, UK
A. John Barrett, MD, FRCP, FRCPath, Chief, Stem Cell Allotransplantation Section, National Institutes of Health, Bethesda, MD, USA
Description
A guide to the practice of stem cell transplantation, its status in the treatment of various disorders and the problems that arise after transplantation, aimed at the whole transplant team.
Contents
PART 1. SETTING THE SCENE
Introduction. Essential biology of stem cell transplantation
PART 2. THE ROLE
OF STEM CELL TRANSPLANTATION IN TREATMENT
Acute myeloid leukaemia. Chronic myeloid leukaemia. Acute lymphoblastic leukemia in
adults. Childhood leukemias. The myelodysplastic syndromes. Multiple myeloma. Hodgkin's disease and non-Hodgkin's lymphoma. Chronic lymphocytic
leukaemia. Solid tumors in children. Breast cancer. Solid tumors in adults. Germ cell tumors. Primary immunodeficiency diseases. Acquired
aplastic anemia and Fanconi anemia. Thalassaemia and sickle cell disease. Lysosomal storage disorders. Autoimmune disorders
PART
3. PREPARATION FOR TRANSPLANT
Patient selection: preliminary interview, screening of apient and donor. Stem cell donor registries.
Cord blood banks and umbilical cord blood transplantation in children and adults. Human leukocyte antigen matching, compatibility testing
and donor selection. Collection and processing of marrow and blood hematopoietic stem cells. Vascular access. High-dose regimens for
autologous stem cell transplantation. Myeloablative conditioning regimens for allogeneic transplantation. Reduced-intensity conditioning
for allogeneic hematopoietic stem cell transplantation. Transplants from unrelated or mismatched family donors. Management of the older
patient.
PART 4. POST-TRANSPLANT CARE
Transfusion medicine support for hematopoietic stem cell transplantation.
The transplant pharmacopoeia. Nutrition support. Barrier precautions, prophylaxis and neutropenic fever. Re-immunization after hematopoietic
stem cell transplantation. Psychological and supportive care issues in the transplant setting.
PART 5. MANAGEMENT OF POST-TRANSPLANT
COMPLICATIONS
Graft failure. Acute graft-versus-host disease. Chronic graft-versus-host disease. Management of relapse and minimal
residual disease after stem cell allografting. Bacterial infections. Viral infections. Fungal infections. Parasitic infections. Multiple
organ failure and intensive care. Late effects.
PART 6. THE WIDER PERSPECTIVE
Starting a hemopoietic stem cell
transplant unit. Ethical and legal considerations in stem cell transplantation. How to build and use a stem cell transplant database.
Blood and marrow transplant organizations. Stem cell transplantation - future prospects.
| Bibliographic details |
Paperback, 512 pages, publication date: SEP-2008
ISBN-13: 978-0-443-10147-2
ISBN-10: 0-443-10147-7
Imprint: CHURCHILL LIVINGSTONE
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999/999
Last update: 25 Nov 2009
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