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| MICROARRAY TECHNOLOGY IN PRACTICE
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To order this title, and for more information, click here
By
Steve Russell, University of Cambridge, UK
Lisa Meadows, University of Cambridge, London UK
Roslin Russell, University of Cambridge, London UK
Audience
Life science professionals and graduate students
Contents
Contents
1. What are microarrays?
A. The basics
2. Designing and producing a microarray
A. Platform options
B. Oligonucleotide design
C. Whole genome or boutique arrays
D. The problems of multiple testing
E. Array layout
F. Quality assessment
3. Sample collection
and labelling
A. RNA extraction
B. Quality assessment
C. Direct labelling techniques
D. Indirect labelling techniques
E. End labelling
techniques
F. Amplification techniques
G. Hybridization
4. Data acquisition
A. Scanners
B. Image acquisition
C. Multiple scans
and data merging
D. Finding spots
E. Background measurement
G. Quality control basics
5. Experimental Design and Data Normalisation
A. Experimental design
B. Why normalize?
C. Unwanted signal variation
D. Common normalization approaches
E. Data transformation
F. Dealing with ?S'-shaped trends
G. Replicates and spatial detrending
H. Normalization of single channel arrays
6. Meta analysis
A. Data filtering
B. Screening for differentially expressed genes
C. Hierarchical clustering
D. Other clustering techniques
E. Components
analysis
F. Prediction tools
7. Data annotation, storage and submission
A. Functional data annotation
B. Microarray databases
C. Public repositories
8. Applications in health & disease
A. Malaria – parasite expression
B. Cancer classification
C. Diagnostic
Arrays
9. It's not all gene expression
A. ChIP-array
B. CGH
C. Protein arrays
D. Cell arrays
| Bibliographic details |
Paperback, 464 pages, publication date: OCT-2008
ISBN-13: 978-0-12-372516-5
ISBN-10: 0-12-372516-X
Imprint: ACADEMIC PRESS
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| Price and Ordering |
Price:
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GBP 35.99
USD 59.95
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Last update: 25 Nov 2009
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