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| MULTIPLE MYELOMAS, AN ISSUE OF HEMATOLOGY / ONCOLOGY CLINICS, 21-6
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By
Kenneth Anderson, MD, Chief, Division of Hematologic Neoplasia; Director, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute; Kraft Family
Professor of Medicine, Joint Program in Transfusion Medicine, Harvard Medical School, Boston, MA
Included in series
The Clinics: Internal Medicine,
Description
Although treatable with conventional and high dose therapies, multiple myeloma (MM) remains incurable. However, recent advances in oncogenomics,
coupled with increased understanding of the role of the bone marrow (BM) microenvironment in MM pathogenesis, has provided the basis
for a new treatment paradigm targeting the tumor cell in the BM milieu to overcome conventional drug resistance and improve patient outcome.
This text will first describe advances in molecular pathogenesis of MM due to cutting edge comparative genomic hybridization, gene microarray,
and proteomic profiling of MM cells. The molecular basis for the growth, survival, drug resistance, and migration of MM cells, including
extracellular matrix proteins, BM stromal cells, and cytokines in the BM milieu, will next be delineated using both laboratory and animal
model systems. Importantly, recent advances in the pathogenesis of bone disease in MM will be described. These preclinical studies
all will set the stage for the bench to bedside translation of scientific advances to the clinic to improve patient outcome. The clinical
approach to patients with plasma cell dyscrasias has been transformed in the past 5 years. There are now uniform definitions of monoclonal
gammopathy of unclear significance and improved predictors of who will develop MM. Biologically-based prognostic factors form the basis
for new staging systems predictive of patient outcome. The approach to the patient with newly diagnosed, relapsed, and relapsed refractory
MM has been transformed, with improved overall and extent of response as well as progression-free and overall survival, in both transplant
candidates and elderly patients. Novel targeted therapies and immune-based strategies hold great promise to enhance treatment options
even further. Finally our ability to identify, prophylax, and treat complications of MM and its treatment has advanced in a parallel
fashion. Myeloma therefore represents a novel treatment paradigm targeting the tumor cell, tumor host interaction, and tumor microenvironment
which can serve as a model to outcome in patients with other hematologic cancers and solid tumors as well.
| Bibliographic details |
Hardbound, 0 pages, publication date: DEC-2007
ISBN-13: 978-1-4160-5082-7
ISBN-10: 1-4160-5082-5
Imprint: SAUNDERS
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041/407
Last update: 10 Sep 2009
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