Description The dentate gyrus is a part of the brain that has been a topic of intense interest since the beginning of neuroscience, and pioneering
studies from the distant and recent past attest to this. One of the reasons for such interest is that this structure provides some of
the most remarkable examples of plasticity within the nervous system. In addition, it is critical to normal cognitive function, although
exactly how and when is still a question that eludes answers. Furthermore, abnormalities within the dentate gyrus appear to play a role
in diverse clinical conditions, from depression to epilepsy and traumatic brain injury. The primary goal of this book is to provide a
context, or background, upon which the detailed knowledge of the current era can be appreciated. A series of overviews are provided
to clarify essentials related to structural organization and development, cellular components, neurotransmitters and neuromodulators,
plasticity, and clinical relevance.
Audience
Neuroscientists, neurologists, neuroendocrinologists, neuropharmacologists and psychologists.
Contents Section I. Functional Organization and Development.
1. Intrinsic.
2. Comparative anatomy of the hippocampal dentat gyrus in adult and
developing rodents, non-human primates and humans.
3. The perforant path: projections from the entorhinal cortex to the dentate gyrus.
4. Extrinsic afferent systems to the dentate gyrus.
5. The mossy fibers.
6. Mossy fiber synaptic transmission: communicating from dentate
gyrus to area CA3.
7. Development of cell and fiber layers in the dentate gyrus.
8. Genetic regulation of dentate gyrus morphogenesis.
Section II. Cellular Analyses.
9. Ultrastructure and synaptic connectivity of cell types in the adult rat dentate gyrus.
10. Morphological
development and maturation of granule neuron dendrites in the rate dentate gyrus.
11. Physiological studies of human dentate granule
cells.
12. Hilar mossy cells: functional identification and activity in vivo.
13. Interneurons of the dentate gyrus: an overview of cell
types, terminal fields and neurochemical identity.
Section III. Neurotransmitters and Neuromodulators.
14. Functional regulation of
the dentate gyrus by GABA-mediated inhibition.
15. Opioid systems in the dentate gyrus.
16. Somatostatin in the dentate gyrus.
17. Neuropeptide
Y in the dentate gyrus.
18. Norepinephrine and the dentate gyrus.
19. Endocannabinoids in the dentate gyrus.
20. Pro-inflammatory cytokines
and their effects in the dentate gyrus.
21. Role of corticosteroid hormones in the dentate gyrus.
22. Neurotrophins.
23. Sex steroids
and the dentate gyrus.
Section IV. Plasticity.
24. Platic processes in the dentate gyrus: a computational perspective.
25. Control of
synaptic consolidation in the dentate gyrus: mechanisms, functions, and therapeutic implications.
26. Comparison of cellular mechanisms
of long-term depression of synaptic strength at perforant path-granule cell and Schaffer collateral-CA1 synapses.
27. Structural reorganization
of the dentate gyrus following entorhinal denervation - species differences between rat and mouse.
28. Adult neurogenesis in the intact
and epileptic dentate gyrus.
29. Unmasking recurrent excitation generated by mossy fiber sprouting in the dentate gyrus: an emergent
property of a complex system.
Section V. The Dentate Gyrus Network.
30. A behavioural analysis of dentate gyrus function.
31. Matching
computational arguments with morphological and physiological properties to understand dentate functions.
32. The dentate gyrus as a filter
or gate: a look back and a look ahead.
33. Role of the dual entorhinal inputs to hippocampus: a hypothesis based on cue/action (non-self/self)
couplets.
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