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RAPID REFERENCE TO INFLUENZA
Rapid Reference to Influenza
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Second Edition

By
Jan Wilschut, PhD, Professor of Molecular Virology, Department of Medical Microbiology, University of Groningen, Groningen, The Netherlands
Janet McElhaney, MD, FRCPC, Allan M. McGavin Chair in Research Geriatrics, Department of Medicine, University of British Columbia
Abraham Palache, PhD, Global Medical and Public Affairs Director, Influenza Vacines, Solvay Pharmaceuticals, NL; Formerly Influenza Research Fellow at the National Influenza Centre, Erasmus University, Rotterdam, NL

Included in series
Rapid Reference,

Description
The ongoing threat of pandemic influenza is very serious indeed as evidenced by recent articles within The Lancet and The Lancet Infectious Disease. This title provides the reader with authoritative and accessible information on the subject of influenza. Clearly written by key experts in the field and highly illustrated in full colour, the book provides an overview of influenza, its pathogenesis, epidemiology, the burden of disease and its health economics. Rapid Reference Influenza also summarises available information on the molecular biology of influenza and the emergence of new influenza viruses. Completely updated with the latest information on H5N1, the book aims to contribute to international efforts to emphasize the major burden of influenza and the need for better control.

Audience
All physicians and healthcare professionals with an interest in this increasingly important subject

Contents
1. Introduction
The influenza virus
Origin of pandemics and epidemics
Clinical picture and impact of flu
Prevention and control
References

2. The Influenza Virus: Structure and Replication
Classification and nomenclature of influenza viruses
Influenza virus structure
Virus replication
References

3. Influenza Epidemics and Pandemics
Annual influenza epidemics
Origin of influenza pandemics
Influenza pandemics of the past
Will there be a new pandemic?
Influenza pandemic preparedness
Concluding remarks
References

4. The Immune Response to Influenza Infection
The innate immune response
Initiation of the adaptive immune response
Effector mechanisms of the adaptive response
Effect of ageing on the immune system
References

5. Pathogenesis, Clinical Features and Diagnosis
Pathogenesis of influenza
Presentation of uncomplicated influenza
Complications of influenza
Influenza in susceptible subgroups
Diagnosis of influenza
References

6. Social and Economic Impact of Influenza
Social impact
Economic impact
Impact of pandemic influenza
References

7. Antivirals: Treatment, Prophylaxis and Pandemic Control
Mechanisms of action of antivirals
Antivirals in treatment and prophylaxis of influenza
The role of antivirals in pandemic control
References

8. Vaccination: Cornerstone of Influenza Control
Current inactivated influenza vaccines
Vaccination coverage
Benefits of influenza vaccination
How may influenza control be further improved?
References

9. Vaccination: Novel Developments and Pandemic Control
Novel inactivated influenza vaccines with improved efficacy
Mucosal delivery of influenza vaccines
Novel approaches to vaccine virus production
Pandemic vaccines
References

Appendix 1 – Useful Websites
Appendix 2 – WHO Global Agenda for Influenza Surveillance and Control
Appendix 3 – WHO position paper on Influenza Vaccines

Bibliographic details
Paperback, 248 pages, publication date: JUN-2006
ISBN-13: 978-0-7234-3433-7
ISBN-10: 0-7234-3433-6
Imprint: MOSBY


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Last update: 30 Nov 2009
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