Description Gamma-aminobutyric acid (GABA) was discovered in the brain in 1950 by Eugene Roberts. GABA is now considered one of the most important
neurotransmitters and developmental signals. Knowledge on the complexity of GABA function is increasing exponentially. This volume covers
basic research on GABA in the developing brain as it may relate to onset of autism and related developmental disorders. The evidence
that dysfunction of GABA and related molecules is associated with autism is limited but expanding and seems to converge. Pertinent data
are reviewed in this book and new research avenues in the basic and clinical arenas are described. The topics are of imminent interest
to basic and clinical researchers as well as interested clinicians.
Audience
Neurologists, neurosurgeons, neuroradiologists and other neuroscientists who are dedicated to the advancement of techniques used to evaluate the neurobiology of autism.
Contents Foreword by Eugene Roberts
Autism: neuropathology, alterations of the GABAergic system, and animal models
The role of GABA in the early
neuronal development
GABAergic signaling in the developing cerebellum
Insights into GABA functions in the developing cerebellum
Role
of GABA in the Mechanism of the Onset of Puberty in Non-Human Primates
Rett Syndrome: A Rosetta Stone for Understanding the Molecular
Pathogenesis of Autism
GABAergic Cerebellar System in Autism: A Neuropathological and Developmental Perspective
Reelin Glycoprotein in
Autism and Schizophrenia
Is there a connection between autism, Prader-Willi syndrome, catatonia and GABA?
The role of GABA in prenatal
alcohol exposure
Effects of secretin on extracellular GABA and other amino acid concentractions in the rat hippocampus
Predicted therapeutic
role of secretin and oxytocin in augism: Implications for treatment of mental illness
Immunological Findings in Autism
Correlates of
psychomotor symptoms in autism
Gabrb3 Gene Deficient Mice: A Potential Model of Autism Spectrum Disorder
The Reeler Mouse: Anatomy of
a Mutant
GABA-A receptor mutations in epilepsy and other disorders
Shared chromosomal susceptibility regions between autism and other
mental disorders
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