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| CHEMISTRY AND BIOLOGY OF HEPARIN AND HEPARAN SULFATE
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Edited By
Hari Garg, Faculty of Medicine, Harvard Medical School, Boston, MA, USA
Robert Linhardt, Rensselaer Polytechnic Institute, Troy, New York, USA
Charles Hales, Pulmonary and Critical Care unit, Harvard Medical School Massachusetts General Hospital, Boston, USA
Description
The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking
- heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate
provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their
function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity
of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source
for updating their current knowledge of developments in this area.
Audience
Chemists, biochemists, medical doctors, researchers, students and practitioners
Contents
1. Structure and Active Domains of Heparin
(B. Casu).
2. Structure and Function of Cell Associated and Pericellular Heparan Sulfate
Proteoglycans (S.G. Velleman and C. Liu).
3. Methods for Structural Analysis of Heparin and Heparan Sulfate (I. Capila et
al.).
4. Synthetic Approach to Define Structure-Activity Relationship of Heparin and Heparan Sulfate
(C. Noti, P.H. Seeberger).
5. Biochemical and Pharmacological Rationale for Synthetic Heparin Polysaccharides (J.M. Walenga et al.).
6. Seperation
and Sequencing of Heparin and Heparan Sulfate Saccharides (M.A. Skidmore, J.E. Turnbull).
7. Biosynthesis of Heparin and Heparan
Sulfate
(Shuji Mizumoto et al.).
8. Remodeling of Heparan Sulfate by Extracellular Endosulfatases (Xinbin Ai et al.).
9. Heparan Sulfate Degradation by Heparanases
(K.J. Bame).
10. Lysosomal Degradation of Heparin and Heparan Sulfate (P.J. Meikle et al.).
11. Heparin Regulation of the Complement System
(Haining Yu et al.).
12. Surface-Based Studies
of Heparin/Heparan Sulfate-Protein Interactions: Consideartions for Surface Immobilisation of HS/Heparin Saccharides and Monitoring their
Interactions with Binding Proteins (T. Rudd et al.).
13. Heparin Activation of Serpins (J.A. Huntington).
14. Role
of Heparin in Fibroblast Signalling (N.J. Harmer).
15. Role of Anticoagulant Heparan Sulfate in Mammalian Reproduction (A.I. de
Agostini et al.).
16. Glycol-Splitting as a Device for Modulating Inhibition of Growth Factors and Heparanase by Heparin
and Heparin Derivatives (A. Naggi).
17. Antithrombin Activation and Designing Novel Heparin Mimics (U.R. Desai).
18. Influence
of Heparin Chemical Modifications on Its Antiproliferative Properties (H.G. Garg et al.).
19. Mechanisms of Cell Growth
Regulation by Heparin and Heparan Sulfate (M.A. Nugent et al.).
20. Heparin and Low Molecular Weight Heparin in Thrombosis
and Inflammation: Emerging Link (S.A. Mousa).
21. Basic and Clinical Differences of Heparin and Low Molecular Weight Heparin Treatment
(D. Hoppenstead et al.).
22. Perlecan: An Extracellular Matrix Heparan Sulfate Proteoglycan that Regulates Key Events in
Vascular Development and Disease (M.G. Kinsella, T.N. Wight).
23. Heparin and Low Molecular Weight Heparins in Clinical Cardiology
(M.E. Korkmaz).
24. Heparin-Induced Thrombocytopenia (T.E. Warkentin, W.E. Dager).
25. Role of Heparan Sulfate in Cancer
(Dongfang Liu, Ram Sasisekharan).
26. Use of Heparin Preparations in Older Patients
(A. Tufano and M.N. Dario Di Minno).
27. Advances in Low Molecular Weight Heparin Use in Pregnancy (A.J. Thomson, I.A. Greer).
| Bibliographic details |
Hardbound, 792 pages, publication date: DEC-2005
ISBN-13: 978-0-08-044859-6
ISBN-10: 0-08-044859-3
Imprint: ELSEVIER
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| Price and Ordering |
Price:
GBP 236
USD 355
EUR 277.95
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Last update: 10 Sep 2009
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