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| CARDIAC MECHANO-ELECTRIC FEEDBACK AND ARRHYTHMIAS
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By
Peter Kohl, MD, PhD, Royal Society Research Fellow, Professor of Dermatology, Director Department of Dermatology & Venerology Vivantes Klinikum
Neukolln Academic Teaching Hospital of Charite University Medicine Berlin
Frederick Sachs, PhD, Distinguished Professor of Biophysics, Centre for Single Molecule Biophysics at the Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, NY, USA
Michael Franz, MD, PhD, Professor, Department of Pharmacology; Director, Arrhythmia Service, Veterans Affairs Medical Center, Georgetown, Washington, DC, USA
Description
Better understand the mechanisms of arrhythmia, cellular modifiers, and the clinical answers to these disorders! Written by internationally
recognized leaders in the field, this groundbreaking resource reflects the state of the art in all aspects of mechanical heart function.
Readers will find detailed discussions of mechanisms of feedback * effects on cellular electrophysiology * experimental manifestations
* normal physiology * pathogenic mechanisms * therapeutic interventions * and more.
Audience
Cardiac Electrophysiologists, Cardiologists
Contents
Introduction
* Cardiac mechano-electric interactions and the induction & termination of arrhythmia
Fundamental
Mechanisms of Cardiac Mechano-Electric Feedback
* Cardiac non-selective stretch-activated cation channels: pathophysiological
potential
* Mechanical modulation of cardiac potassium channels
* Cell-volume activated ion channels in cardiac cells
* Contribution
of cytoskeleton and lipid bi-layer to cellular mechano-reception
* The response of cardiac muscle to stretch: role of calcium
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Stretch-effects on second messengers and early gene expression
Cellular Effects of Mechano-Electric Feedback
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Differential effects of stretch on cardiac cells in diastole and systole
* Differential effects of stretch and compression of cardiac
cells
* Mechanical modulation of cardiac non-myocyte structure and function
* Mechanical effects on auto- & paracrine signalling
in cardiac myocytes and non-myocytes
* Stretch effects on connexin expression in cardiac cells
Mechano-Electric Feedback
in Cardiac Tissue and Whole Heart
* Mechanical modulation of sino-atrial pacemaking rate
* Stretch effects on atrial
conduction and refractoriness
* Stretch effects on ventricular conduction and refractoriness
* Neuro-humoral modulation of cardiac
mechano-electric interactions
* Mechanically-induced repolarization dispersion and the mechanical vulnerable period
* Experimental
arrhythmogenesis by acute mechanical stimulation (Commotio cordis)
* Specific stretch-channel blockers: a new class of anti-arrhythmic
drugs
Clinical Evidence for Cardiac Mechano-Electric Feedback in Man
* Non-neuronal component of respiratory
sinus arrhythmia
* Induction of arrhythmias by precordial impact
* Arrhythmogenesis during cardiac catheterisation
* Role of
transmural gradients in mechano-electric interactions
* Hemodynamic unloading and termination of arrhythmias
* Bypass-induced ventricular
load changes and action potential configuration
* Termination of ventricular arrhythmia by acute mechanical interventions
Clinical
Relevance of Cardiac Mechano-Electric Feedback
* Cardiac mechanics and the ECG U-wave
* Arrhythmias in ischaemic heart
disease in linkage with regional wall motion abnormalities
* Arrhythmogenic potential of dysynergy of ventricular mechanics in patients
with heart failure and wide QRS complex
* Bi-ventricular pacing as a new treatment modality to restore ventricular synchronization
* Atrial fibrillation in dilated cardiomyopathy
* The angiotensin-renin pathway in left ventricular hypertrophy and SCD
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Volume and pressure overload and ventricular arrhythmogenesis
* Mortality from heart failure: haemodynamic versus electrical causes
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Passive ventricular constraint: new treatment concept for dilated cardiomyopathy
* Mechanical modulation of defibrillation efficacy
by preload changes
* Mechanical advances in cardiopulmonary resuscitation
Clinical Trials Evaluating Survival Benefits
by Ventricular Unloading or Resynchronization
* Effects of bi-ventricular pacing on cardiac mortality and arrhythmias – the Companion trial
* InSync Trial
* Counter-pulsation and cardiac assist devices.
* New intra-ventricular chamber reduction
devices (Percutaneous catheter mediated endocardial ventriculoplasty for patients with heart failure).
* Ventricular restraint study
and reverse re-modeling in patients.
* Evolving concepts in measuring ventricular stress-strain relations in the human heart
Index
| Bibliographic details |
Hardbound, 448 pages, publication date: APR-2005
ISBN-13: 978-1-4160-0034-1
ISBN-10: 1-4160-0034-8
Imprint: SAUNDERS
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Last update: 10 Sep 2009
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