Description There is a vast and often bewildering array of synthetic methods and reagents available to organic chemists today. The Best Synthetic
Methods series allows any scientist who is interested in the chemical transformations of molecules to choose between all the alternatives
and assess their real advantages and limitations. With the emphasis on laboratory use, these volumes represent a comprehensive and practical
guide to modern synthetic organic chemistry.
This book is the product of the author's many years practical experience and reading of
the original literature. It contains a valuable distillation and critical evaluation of the Best Synthetic Methods for the formation
and reaction of molecules containing carbon-carbon triple bonds or cumulative carbon-carbon double bonds. A brief review of each area
is provided, but the emphasis in all cases is on describing efficient practical methods to effect the transformations described. The
reader can therefore use this book to rapidly review and select the best methods of performing a synthetic conversion to create or modify
a molecule containing an acetylene, allene or cumulene functionality. In addition, the documentation of a large number of experimental
recipes enables the user to synthesise an unsaturated molecule without the need to access to the original literature.
Audience
For general supplementary reading and as a reference book for use in organic chemistry research laboratories. It is also appropriate as
a supplementary text and reference book for university courses and for the practical classes on synthetic organic chemistry.
Contents Procedures and Equipment. Preparation, Purification and Storage of Some Solvents and Reagents. Generation of Metallated Acetylenes, Allenes
and Cumulenes. Reactions of Metallated Acetylenes and Allenes with Alkylating Agents. Reactions with Aldehydes and Ketones. Carboxylation,
Acylation and Related Reactions. Silylation, Stannylation and Phosphorylation. Sulfenylation and Related Reactions. Halogenation of Acetylenes.
Acetylenes, Allenes and Cumulenes by Elimination Reactions. Cumulenes by Dehalogenation of Geminal Dihalogenocyclopropanes. Acetylenic
and Allenic Derivatives by Substitution on sp- and sp2-Carbon. Aminoalkylation of Acetylenic Compounds. Cross-Coupling between
1-Alkynes and 1-Bromo-1-alkynes. Copper Halide-Catalysed Oxidative Coupling of Acetylenes. Transition Metals-Catalysed Couplings of Acetylenes
with sp2-Halides. Base-Catalysed Isomerisations of Acetylenic Compounds. Allenic Compounds by 2,3- and 3,3-Sigmatropic Rearrangements.
Miscellaneous Reactions of Acetylenic and Allenic Compounds. Transformation of Functional Groups in Acetylenic and Allenic Compounds.
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