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| COCAINE ABUSE
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Behavior, Pharmacology, and Clinical Applications
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Edited By
Stephen Higgins, University of Vermont, Burlington, U.S.A.
Jonathan Katz, University of Maryland, Baltimore, U.S.A.
Description
Cocaine abuse remains a major public health problem and contributes to many of our most disturbing social problems, including the spread
of infectious disease, crime, violence, and neonatal drug exposure. Cocaine abuse results from a complex interplay of behavioral, pharmacological,
and neurobiological determinants. While a complete understanding of cocaine abuse is currently beyond us, significant progress has been
made in preclinical research on fundamental determinants of this disorder. These advances are critically reviewed in the first section
of this volume. Important advances also have been made in characterizing the clinical pharmacology of cocaine, and those advances have
been extended to understanding individual vulnerability to cocaine abuse, development of effective treatments, and discussions of policy.
Those advances are critically reviewed in the third section of this volume. Contributors to the book were selected because of their status
as internationally recognized leaders in their respective areas of scientific expertise. Moreover, each is a proponent of the importance
of a rigorous, interdisciplinary scientific approach to effectively addressing the problem of cocaine abuse. As such, this volume offers
a coherent, empirically-based conceptual framework for addressing cocaine abuse that has continuity from the basic research laboratory
through the clinical and policy arenas. Each of the specific chapters is sufficiently detailed, in-depth and current to be valuable to
informed readers with specific interests while also offering a comprehensive overview for those who might be less informed or have broader
interests in cocaine abuse. This blend of critical review within each chapter with an explicitly conceptual continuity that spans all
of the chapters makes this volume a unique contribution to cocaine abuse in particular and substance abuse in general.
Audience
Academic researchers, therapists, psychologists, psychiatrists, pharmacologists, and neuroscientists interested in the behavioral ramifications or medicinal chemistry of cocaine and cocaine abuse.
Contents
P.B. Dews, Forward.S.T. Higgins and J.L. Katz, Preface.S. Izenwasser, Basic Pharmacological Mechanisms of
Cocaine.S.B. Caine, Neuroanatomical Bases of the Reinforcing Stimulus Effects of Cocaine.J. Bergman and J.L. Katz,
Behavioral Pharmacology of Cocaine and the Determinants of Abuse Liability.M.E. Carroll and W.K. Bickel, Behavioral-Environmental
Determinants of the Reinforcing Functions of Cocaine.W.L. Woolverton and S.R.B. Weiss, Tolerance and Sensitization to Cocaine:
An Integrated View.G. Winger, Preclinical Evaluation of Pharmacotherapies for Cocaine Abuse.K.F. Schama, L.L. Howell,
and L.D. Byrd, Prenatal Exposure to Cocaine.M.W. Fischman and R.W. Foltin, Cocaine Self-Administration Research: Implications
for Rational Pharmacotherapy.G.E. Bigelow and S.L. Walsh, Evaluation of Potential Pharmacotherapies: Response to Cocaine Challenge
in the Human Laboratory.C.R. Rush, J.M. Roll, and S.T. Higgins Controlled Laboratory Studies on the Effects of Cocaine in Combination
with Other Commonly Abused Drugs in Humans.S.E. Lukas and P.F. Renshaw, Cocaine Effects on Brain Function.G.I. Elmer,
L.L. Miner, and R.W. Pickens, The Contribution of Genetic Factors in Cocaine and Other Drug Abuse.H.D. Chilcoat and C-E. Johanson,
Vulnerability to Cocaine Abuse.S.T. Higgins and C.J. Wong, Treating Cocaine Abuse: What Does Research Tell Us?K. Silverman,
G.E. Bigelow, and M.L. Stitzer, Treatment of Cocaine Abuse in Methadone Maintenance Patients.S.M. Hall, D.A. Wasserman, B.E.
Havassy, and P. Maude-Griffin Relapse to Cocaine Use.T.J. Crowley and J.T. Brewster, Cocaine Legalization: Designing the
Experiments.
Index.
| Bibliographic details |
Hardbound, 445 pages, publication date: SEP-1998
ISBN-13: 978-0-12-347360-8
ISBN-10: 0-12-347360-8
Imprint: ACADEMIC PRESS
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Last update: 30 Nov 2009
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