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| ALKALOIDS: CHEMICAL AND BIOLOGICAL PERSPECTIVES, VOLUME 12, 12
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Edited By
S.W. Pelletier, Institute for Natural Products Research, Chemistry Building, The University of Georgia, Athens, Georgia 30602-2556, USA
Included in series
Alkaloids: Chemical and Biological Perspectives, 12
Description
Acronycine, a potent antitumor agent, was discovered in the bark of the small Australian Rutaceous tree, Acronychia baueri Schott.
This new work presents a comprehensive survey of the isolation, structure determination, methods of synthesis, and the biological properties
of acronycine, as well as an account of natural and synthetic analogues of acronycine, and their biological properties.
Solanum alkaloids
were reviewed in 1990 and this book surveys the new developments (isolation procedures, structural elucidation methods) and critically
updates earlier reviews.
In addition it presents the interesting chemistry and synthesis of cyclopeptide alkaloids. These cyclopeptide
alkaloids have been isolated from ascidians, sea hares, and cyanobacteria.
Also included are reviews of the use of the functionalized
lactam, pyroglutamic acid, as a chiral template for the synthesis of alkaloids.
The second review examines the on-line coupling of
capillary electrophoresis (CE) and mass spectrometry (MS) for the analysis of alkaloid mixtures.
Finally a review of oxygenated analogs
of the alkaloid Marcfortine for their potent antiparasitic activity is included at the end of this work.
Each chapter in this volume
has been reviewed by at least one expert in the field. Indexes for both subjects and organisms are provided.
Audience
For scientists working in the fields of natural product chemistry, medicinal chemistry, pharmacology and biochemistry.
Contents
Acronycine-type alkaloids: chemistry and biology (F. Tillequin et al.). Solanum steroid alkaloids - an update (H. Ripperger).
Synthesis and structure-activity studies of Lissoclinum peptide alkaloids (P. Wipf). Pyroglutamate as a chiral template for
the synthesis of alkaloids (M.B. Smith). Analysis of alkaloids by capillary electrophoresis and capillary electrophoresis - electrospray
mass spectrometry (J. Stöckigt et al.). Oxidation of anthelmentic marcofortine A, an indole alkaloid (B.H. Lee et al.).
Subject index. Organism index.
| Bibliographic details |
Hardbound, 0 pages, publication date: APR-1998
ISBN-13: 978-0-08-042805-5
ISBN-10: 0-08-042805-3
Imprint: PERGAMON
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Last update: 10 Sep 2009
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