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| GENE THERAPY OF THE CENTRAL NERVOUS SYSTEM: FROM BENCH TO BEDSIDE
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Edited By
Michael Kaplitt, New York Hospital, Cornell University Medical College and Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, U.S.A.
Matthew During
Description
Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment
so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology
for basic research and has recently been translated to human therapy in several landmark clinical trials.
Gene Therapy of
the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers
of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise
of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides
clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications
in research and clinical praxis.
Audience
Neuroscientists, geneticists, molecular biologists, pharmaceutical companies
Contents
SECTION I. GENE TRANSFER TECHNOLOGY AND REGULATORY ISSUES
1. Design and optimization of expression cassettes including promoter choice
and regulatory lements
2. Identification of Novel AAV Serotypes for Use as Vectors
3. HSV amplicon vectors for gene delivery to the
nervous system
4. Influence of the immune system on CNS gene transfer
5. Targeted induction of endogenous neural stem and progenitor
cells: A new strategy for gene therapy of neurological disease
6. Neurosurgical Targeting, Delivery and Infusion of Gene Therapy Agents
in the Brain
7. Gene Transfer for Neurological Disease: Agencies, Policies and Process
SECTION II. GENE THERAPY FOR DEGENERATIVE AND
FUNCTIONAL DISORDERS
8. Gene therapy for Parkinson's disease
9. Non human primate models for testing gene therapy for neurodegenerative
disorders
10. Delivery of Molecular Therapeutics into the CNS and their Distribution within the Brain
11. Gene therapy for CNS diseases
using intrabodies
12. Gene therapy for epilepsy
SECTION IIII. PSYCHIATRIC AND BEHAVIORAL GENE THERAPY
13. Genetic manipulation of
learning and memory
14. Psychiatric applications of viral vectors
15. Use of viral vectors to influencebehavior
SECTION IV. GENE THERAPY
FOR PAIN AND SPINAL CORD DISEASES
16. Herpes simplex vector mediated gene transfer to the peripheral nervous system for the treatment
of polyneuropathy and chronic pain
17. Characterization of pain receptors in the spinal cord using a viral vector for spatial-temportal
gene targeting
18. Viral vector mediated gene therapy of pain
19. VEGF, an angiogenic factor with neurotrophic activity, useful for treatment
of ALS?
20. Viral Vector Axonal Uptake and Retrograde Transport: Mechanisms and Applications
21. Gene therapy for spinal cord injury
V. GENE THERAPY FOR BRAIN TUMORS AND NEUROGENETIC DISEASES
22. Prodrug-Activation Gene Therapy
23. Clinical trials of gene therapy
for Canavan Disease
24. Gene therapy for the late infantile form of Batten disease
25. Molecular Imaging of Gene Therapy for Neurogenetic
Diseases
| Bibliographic details |
Hardbound, 370 pages, publication date: NOV-2005
ISBN-13: 978-0-12-397632-1
ISBN-10: 0-12-397632-4
Imprint: ACADEMIC PRESS
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| Price and Ordering |
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095/945
Last update: 20 Feb 2010
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