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 Novel Findings of Gene Diagnosis, Regulation of Gene Expression, and Gene Therapy
Proceedings of the Second Meeting of the Hirosaki International Forum of Medical Science, Hirosaki, Japan, 7 July 1998
Edited by
I. Hashimoto, Hirosaki University School of Medicine, Dept. of Dermatology, Zaifu-cho, Hirosaki 036, Japan
H. Shinkawa, Hirosaki University School of Medicine, Dept. of Otorhinolaryngology, Zaifu-cho, Hirosaki 036, Japan
T. Suda, Hirosaki University School of Medicine, Dept. of Medicine, Zaifu-cho, Hirosaki 036, Japan
S. Tsuchida, Hirosaki University School of Medicine, Dept. of Biochemistry, Zaifu-cho, Hirosaki 036, Japan
S. Yagihashi, Hirosaki University School of Medicine, Dept. of Pathology, Zaifu-cho, Hirosaki 036, Japan
J. Uitto, Thomas Jefferson University, Jefferson Institute of Molecular Medicine, Dept. of Dermatology and Cutaneous Biology, Philadelphia, PA, USA
Included in series
International Congress, 1172
Description
Over the past decade, with the development of gene technology, there has been an explosion in knowledge about genetic alternations as
cause or pathogenesis of many diseases. This establishes a new field, molecular medicine, revolutionizing diagnosis and treatment of
such diseases.
This book, proceedings of a symposium on molecular medicine held as the Second Meeting of Hirosaki International Forum
of Medical Science, provides in-depth information on recent advance in gene diagnosis, regulation of gene expression, and gene therapy.
In the section of gene diagnosis, recent topics on epidermolysis bullosa, an inherited blistering skin disease, and hereditary hearing
loss have been presented. Regulation of gene expression focuses on corticortropin-releasing hormone gene and genes encoding drug-metabolizing
enzymes, as examples under sophisticated control and biological importance. Gene therapy includes development of novel in vivo gene delivery
systems and its application to the treatment of diseases. These overviews and other recent research works will invite the readers to
an amazing new world of molecular medicine.
Audience
Researchers of the fields including biochemistry, pathology, internal medicine, dermatology, and otology
Contents
Chairman's Address. Preface. Gene diagnosis.
Molecular genetics of the cutaneous basement membrane zone: clinical implications
of basic research on epidermolysis bullosa (J. Uitto). Genetic Testing of Hearing Loss Disorders (W.J. Kimberling). Sensorineural hearing
loss caused by the A1555G mutation in the mitochondrial DNA (S. Abe et al.). A mutation in plasma platelet-activating factor
acetylhydrolase gene (G994 → T) is a genetic risk factor for stroke (K. Satoh et al.).
Genotype-phenotype correlation
of autosomal dominant retinal degenerations with mutations in the peripherin/RDS gene (M. Nakazawa et al.). Recent studies on
DNA-based diagnosis for Japanese cases of dystrophic epidermolysis bullosa (K. Tamai et al.).
A novel KIT gene missense
mutation in a Japanese family with piebaldism (K. Nomura et al.).
Genetic study for ossification of posterior longitudinal ligament
of the spine (T. Numasawa et al.).
Angiotensin converting enzyme gene polymorphism in lupus nephritis (H. Osawa et al.).
CYP2D6 genotype and plasma levels of haloperidol and reduced haloperidol in Japanese ( T. Kondo et al.).
Regulation of gene
expression.
Corticotropin-releasing hormone: new aspects of regulation and lessons from knockout mice (J.A. Majzoub).
Regulation
of hypothalamo-hypophyseal vasopressinergic neurons by glucocorticoids (M. Shoji et al.). Nrf1 and Nrf2 regulate ARE-mediated
expression and coordinated induction of a battery of genes encoding proteins that protect cells against oxidative stress (A.K. Jaiswal).
Pi-class glutathione tranferase expression and function in mouse neoplasia (S. Tsuchida et al.). Human small MAF proteins form
hetrodimers with CNC family transcription factors and recognize the NF-E2 motif (E. Ito et al.). Approaches to intestinal γδT
cells ( Y. Ishiguro, H. Kanazawa, A. Munakata). Metallothionein-null mouse exhibits reduced tolerance against ultraviolet-B injury in
the skin (K. Hanada et al.).
Gene structural similarity between hCRF-R1 and glucagon receptor family (K. Sakai et al.).
Evaluation of CAR, Smad4, and KAI1 expression in colorectal tumors by a RT-PCR method (T. Mikami et al.).
Cytokine
expression and synthesis in oral squamous cell carcinoma (Y. Nakano et al.).
Roles of cytokines in host defense to bacterial
infections in mice (A. Nakane et al.).
TGF-β/Smad and TNF-α/NF-KB upregulate type VII collagen gene expression additively
at the transcriptional level (A. Kon et al.).
Expression of the apoptosis-related genes in colorectal cancers (H. Odagiri et
al.).
Primary structure and developmental state-specific expression of the mouse γ-aminobutyraldehyde dehydrogenase (K. Ishii et al.).
Gene therapy.
Development of a novel in vivo gene delivery system for human gene therapy (Y. Kaneda).
In vivo introduction of the interleukin 6 gene into keratinocytes (D. Sawamura et al.).In vivo introducing
cytokine genes into keratinocytes for approaching to cytekine gene therapy (X. Meng et al.).
Index of authors. Keyword index.
Bibliographic & ordering Information
Hardbound, 234 pages, publication date: JUN-1999
ISBN-13: 978-0-444-50006-9
ISBN-10: 0-444-50006-5
Imprint: EXCERPTA MEDICA
Price: Order form
EUR 131
GBP 87.50
USD 131
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Last update: 4 Aug 2008
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