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| GENETICS AND PSYCHIATRIC DISORDERS
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Edited by
J. Wahlström
Included in series
Wenner-Gren International Series, 69
Description
Over the past few years, there has been much research into, and subsequent advances in our understanding of, the genetic causes of psychiatric
illness. Most neuropsychiatric diseases have a multifactorial background - both genetic and environmental factors are important for the
development of the disease. The advantages of understanding the inherited component of a psychiatric disease are obviously great, and
will eventually lead to more effective treatments.
The chapters in this volume are specifically concerned with the latest advances
in finding biological and genetic markers for psychiatric disorders. An emphasis is placed on common diseases such as schizophrenia and
bipolar disorders. However, for instance, monogenetic inherited diseases with psychiatric symptoms which can serve as models for the
inheritance of psychiatric disorders are also discussed.
For neuroscientists, geneticists, biological psychiatrists and all those
with an interest in the causes of psychiatric disorders.
Contents
Preface. List of contributors.
Special Lecture.
Human genetic diversity and neuropsychiatric disorders (K.K. Kidd).
Section
I. Methods and Models.
Paralogous genes and nervous systems (L-G. Lundin, D. Larhammar). The candidate gene approach in psychiatric
disorders: the example of tyrosine hydroxylase (J. Mallet, R. Meloni). Molecular analysis of genomes and genes (U. Landegren). The molecular
basis for acute intermittent prophyria, an inherited disease associated with neurological and psychiatric disturbances (P.M. Shoolingin-Jordan,
S.P. Wood).
Section II. Candidate Genes in Psychiatric Disorders.
Genetics of the 5-HT transporter: allelic variation in functional
expression affects anxiety- and depression-related personality traits and suceptibility to affective disorders (P.K. Lesch, A. Heils,
D. Bengel). Genetic variation in human dopamine receptors (M.M. Nöthen, S. Cichon, P. Propping).
Section III. Psychiatric Diseases
and Linkage Studies.
Bipolar disorder: molecular linkage studies (W.H. Berrettini). Genomic screening in manic-depressive disorder
(G.R. Verheyen, C. Van Broeckhoven). Genomic trinucleotide screening in neuropsychiatric disorders (M. Schalling, K. Lindblad, C.E. Burgess,
C. Zander, P-O. Nylander, C. Engström, R. Adolfsson). Unstable DNA in psychiatric disorders (J.B. Vincent, A. Petronis, J.L. Kennedy).
The case for an X-Y homologous locus in the evolution of language and the origins of psychosis (T.J. Crow). Current status of the genetics
of narcolepsy (C.L. Barr, C.M. Shapiro).
Section IV. Dynamic Expansion Related to Psychiatric Disorders.
Genetic anticipation
and brain genes (M.G. McInnis). The fragile X syndrome (P.J. Willems).
Section V. Late Incoming News.
The gene map of psychiatric
disorder (J. Wahlström). Polyglutamine expansions and neurodegenerative diseases (F. Sandou, D. Devys, Y. Trottier, G. Imbert, M-E.
Stoeckel, A. Brice, J-L. Mandel).
Section VI. Clock Genes.
A molecular mechanism for the control of circadian behavioral rhythms
in drosophila (M.W. Young). Biological rhythms and psychiatric disease: focus on melatonin-related genes (D.C. Klein, S.L. Coon,
K. Mazuruk, M. Bernard, P.H. Rosenboom, I.R. Rodriquez).
Section VII. Future Research.
Genomic screening in schizophrenia (H.W.
Moises). Future directions in genetics and psychiatric disorders (P.M. Conneally). Subject Index.
| Bibliographic details |
Hardbound, 340 pages, publication date: MAR-1998
ISBN-13: 978-0-08-042746-1
ISBN-10: 0-08-042746-4
Imprint: ELSEVIER
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| Price and Ordering |
Price:
USD 182
GBP 121.50
EUR 182
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Last update: 8 Nov 2008
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