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| METABOLIC SYNDROME AND PSYCHIATRIC ILLNESS: INTERACTIONS, PATHOPHYSIOLOGY, ASSESSMENT & TREATMENT
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By
Scott Mendelson, Medical Director, Adult Psychiatry Program, Mercy Medical Center, Oregon
Description
Metabolic syndrome is a set of risk factors that includes: abdominal obesity, a decreased ability to process glucose (insulin resistance),
dyslipidemia (unhealthy lipid levels), and hypertension. Patients who have this syndrome have been shown to be at an increased risk of
developing cardiovascular disease and/or type 2 diabetes. Metabolic syndrome is a common condition that goes by many names (dysmetabolic
syndrome, syndrome X, insulin resistance syndrome, obesity syndrome, and Reaven's syndrome).
This is the first book to fully explain
the relationships between psychiatric illness, Metabolic Syndrome, diet, sleep, exercise, medications, and lifestyle choices. Metabolic
Syndrome is a major risk factor in Major Depression, Alzheimer's Disease, Sleep Disorders, Sexual Dysfunction, Fibromyalgia, and several
other illnesses of psychiatric significance. Conversely, some psychiatric illnesses tend to predispose patients to Metabolic Syndrome.
Of further interest is the fact that some of the medications used in the treatment of psychiatric illnesses have been found to cause
or exacerbate Metabolic Syndrome.
The author here provides basic information about what genetic predispositions, medical conditions,
and lifestyle choices make Metabolic Syndrome more likely to occur. Among the contributing factors that are discussed are genetics, habitual
intake of high glycemic index carbohydrates, fructose, saturated fats, trans fatty acids, vitamins, micronutrients, obesity, smoking,
and lack of exercise.
The author describes the actual mechanisms by which Metabolic Syndrome progresses and causes damage in the body,
including the action of insulin and the pathophysiology of insulin resistance. Details are provided on what occurs in the liver, pancreas,
muscle, fat cells, and immune system as Metabolic Syndrome progresses. New findings are presented on fat cells, including the fact that
they are beginning to be considered as endocrine cells. There is a substantive discussion of leptin, which is one of the important adipocytokines.
Also carbohydrate, 'bad fats', inflammation, oxidative damage, over-stimulation of the 'fight or flight' system, and high levels of the
stress hormone cortisol can actually cause the manifestations of Metabolic Syndrome. These explanations set the stage for an explanation
of the inter-relationships between Metabolic Syndrome, psychiatric illness, dementia and effects of not only diet and life choices, but
also the effects of psychiatric medications.
Finally, there is an important and unique section on the relationship between Metabolic
Syndrome and various psychiatric illnesses, and how they exacerbate each other. The significance of Metabolic Syndrome in Major Depression,
Bipolar Affective Disorder, Schizophrenia, fibromyalgia and Polycystic Ovary Disease is vast and it is important to realise the effects
of psychiatric medications on Metabolic Syndrome. The author discusses antidepressants, mood stabilizers and the new atypical antipsychotics.
There are dramatic differences among medications in the way they affect Metabolic Syndrome and pharmaceutical companies will want to
promote patient awareness with this book.
Audience
Psychiatrists, Basic Scientists in Neuroendocrinology and Endocrinology, Nurse Practioners, Primary Care Physicians, Therapists, Psychologists
and other professions in the behavioral health community. Also Pharmaceutical companies, especially those who make atypical antipsychotic
medications.
Contents
The following is an annotated Table of Contents.
1. Gerald Reaven and the Discovery of Syndrome X
2. Factors that Cause Metabolic Syndrome
3. The Pathophysiology of Metabolic Syndrome
4. Metabolic Syndrome and Psychiatric Illness
5. Depression and Heart Disease
6.
Metabolic Syndrome, Insulin, and Alzheimer?s disease
7. Metabolic Syndrome and Sex
8. Sleep, Mood Disorder, and Metabolic Syndrome
9. Diets for weight loss and Metabolic Syndrome
10. A Supplement Primer
11. Conclusion: Metabolic Syndrome and what to do about
it
| Bibliographic details |
Paperback, 224 pages, publication date: NOV-2007
ISBN-13: 978-0-12-374240-7
Imprint: ACADEMIC PRESS
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| Price and Ordering |
Price:
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USD 105
EUR 78.95
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095/945
Last update: 5 Sep 2009
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