Description The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing
impact.
Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity
and function. It emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide
to the conceptual framework of the field.
The textbook includes exercises and worked problems which can provide more independent
learning experiences and can also be used by an instructor leading a class on this topic.
This volume has been written with the advanced
undergraduate and graduate student in mind.
Audience
Advanced undergraduate students or graduate students
Contents
Nature: The Original Combinatorial Chemist
Biopolymers constitute natural libraries
Selection and evolution
The expression of genetic information
Combinatorial assembly of antibody genes
Molecular solutions to combinatorial problems
Synthetic Peptide Libraries
Solid-phase peptide synthesis
Peptides on pins
Other iterative deconvolution
strategies
Examples of split/couple/mix peptide libraries
Positional scanning
Epilogue
Supports, Linkers,
and Reagents for Peptide
Synthesis
Polystyrenes
PEG-grafted supports
Coupling strategies
Supports and
Linkers for Small Molecule Synthesis
New resins and linkers
Ring-forming cleavage
Loading
Encoded Combinatorial
Chemistry
Directed Sorting
Unnatural Oligomers for Library Synthesis
Peptoids
Azatides
Peptidyl phosphonates
Oligoureas
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