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| MEMBRANE LIPID SIGNALING IN AGING AND AGE-RELATED DISEASE, 12
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Edited By
M.P. Mattson, Laboratory of Neurosciences, National Institute on Aging, Gerontology Research Center, Baltimore, MD, USA
Included in series
Advances in Cell Aging and Gerontology, 12
Description
The lipids of cellular membranes not only serve roles in controlling the structure and fluidity of the membrane, but are increasingly
recognized for their roles as signalling molecules and modifiers of membrane protein function. Recent studies described in this volume
reveal striking changes in membrane lipids during aging and in age-related diseases such as cancer, cardiovascular disease and neurodegenerative
disorders. Lipids including inositol phospholipids, cholesterol, sphingolipids and ceramides play important roles in signalling cellular
responses to stress and specific stimuli such as growth factors, cytokines and neurotransmitters. One or more of these lipid mediators
has been linked to the pathogenesis of age-related diseases.
This book provides a comprehensive review of specific membrane lipid
mediators and their roles in aging and age-related disease.
Audience
Neuroscientists, biochemists, cell biologists, cardiologists, neurologists.
Contents
1. Overview: Spatial control of signal transduction by caveolae and lipid rafts (C.J. Fielding). 2. Overview: Membrane lipid peroxidation
(K. Montine, J. Quinn, T. Montine). 3. Regulation of invertebrate longevity by inositol phosphate signaling (C. Wolkow). 4. Ceramide-driven
stress signals in cancer and aging
(P.P. Ruvolo, C. Johnson, W.D. Jarvis). 5. Sphingolipid metabolism and signaling in atherosclerosis
(S. Chatterjee, S. Martin). 6. Sphingolipid and ceramide in brain aging, neuronal plasticity and neurodegenerative disorders (M.P. Mattson,
R.G. Cutler). 7. The eicosanoid pathway and brain aging (H. Manev, T. Uz). 8. Cellular cholesterol, membrane signaling and disease
(J.P.
Incardona). 9. Cholesterol, β-amyloid, and Alzheimer's disease (S. Petanceska, M.A. Pappolla et al.). 10. Phospholipase
A2 in the pathogenesis of cardiovascular disease (E. Hurt-Camejo, P. Sartipy et al.). 11. Retinal docosahexaenoic
acid, age-related diseases and glaucoma (N.G. Bazan, E. Rodriguez).
| Bibliographic details |
Hardbound, 236 pages, publication date: MAY-2003
ISBN-13: 978-0-444-51297-0
ISBN-10: 0-444-51297-7
Imprint: ELSEVIER
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| Price and Ordering |
Price:
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USD 108
GBP 64.99
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Last update: 4 Sep 2009
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