The ubiquitin system: pathogenesis of human diseases and drug targeting
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, In Press, Corrected Proof, Available online 10 November 2004
Aaron Ciechanover and Alan L. Schwartz
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Corrigendum to: "The ubiquitin–proteasome system in cardiovascular diseases—a hypothesis extended" [Cardiovasc. Res. 61 (2004) 11–21]  
Cardiovascular Research, Volume 63, Issue 4, 1 September 2004, Page 756
Joerg Herrmann, Aaron Ciechanover, Lilach O. Lerman and Amir Lerman
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Caspase Activation Inhibits Proteasome Function during Apoptosis
Molecular Cell, Volume 14, Issue 1, 9 April 2004, Pages 81-93
Xiao-Ming Sun , Michael Butterworth , Marion MacFarlane , Wolfgang Dubiel , Aaron Ciechanover and Gerald M. Cohen
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N-terminal ubiquitination: more protein substrates join in
Trends in Cell Biology, Volume 14, Issue 3, March 2004, Pages 103-106
Aaron Ciechanover and Ronen Ben-Saadon
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Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination
Biochemical and Biophysical Research Communications, Volume 314, Issue 2, 6 February 2004, Pages 505-512
Ifat Fajerman, Alan L. Schwartz and Aaron Ciechanover
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The ubiquitin–proteasome system in cardiovascular diseases—a hypothesis extended
Cardiovascular Research, Volume 61, Issue 1, 1 January 2004, Pages 11-21
Joerg Herrmann, Aaron Ciechanover, Lilach O. Lerman and Amir Lerman
 PDF (534 K)        Article via ScienceDirect

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg  
Neuron, Volume 40, Issue 2, 9 October 2003, Pages 427-446
Aaron Ciechanover and Patrik Brundin
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A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1
Biochemical and Biophysical Research Communications, Volume 303, Issue 1, 28 March 2003, Pages 91-97
Eran Nadav, Ayelet Shmueli, Haim Barr, Hedva Gonen, Aaron Ciechanover and Yuval Reiss
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P1645 The coronary ubiquitin proteasome system is functionally active in the early stage of atherogenesis
European Heart Journal, Volume 24, Issue 5, Supplement 1, March 2003, Page 307
J. Herrmann, L. O. Lerman, M. Rodriguez-Porcel, C. Napoli, A. Ciechanover and A. Lerman
 PDF (152 K)

Introduction and overview  
Seminars in Cancer Biology, Volume 13, Issue 1, February 2003, Pages 1-4
A. Ciechanover
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Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes
Journal of the American College of Cardiology, Volume 40, Issue 11, 4 December 2002, Pages 1919-1927
Joerg Herrmann, William D. Edwards, David R. Holmes, Jr , Kris L. Shogren, Lilach O. Lerman, Aaron Ciechanover and Amir Lerman
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Ubiquitin-mediated degradation of cellular proteins in health and disease  
Hepatology, Volume 35, Issue 1, January 2002, Pages 3-6
Aaron Ciechanover and Alan L. Schwartz
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Mechanisms of ubiquitin-mediated, limited processingof the NF- B1 precursor protein p105  
Biochimie, Volume 83, Issues 3-4, March-April 2001, Pages 341-349
Aaron Ciechanover, Hedva Gonen, Beatrice Bercovich, Shai Cohen, Ifat Fajerman, Alain Israël, Frank Mercurio, Chaim Kahana, Alan L. Schwartz, Kazuhiro Iwai and Amir Orian
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Mutation of the E6-AP Ubiquitin Ligase Reduces Nuclear Inclusion Frequency While Accelerating Polyglutamine-Induced Pathology in SCA1 Mice  
Neuron, Volume 24, Issue 4, December 1999, Pages 879-892
Christopher J. Cummings, Eyal Reinstein, Yaling Sun, Barbara Antalffy, Yong-hui Jiang, Aaron Ciechanover, Harry T. Orr, Arthur L. Beaudet and Huda Y. Zoghbi
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Ubiquitin Ligase Activity and Tyrosine Phosphorylation Underlie Suppression of Growth Factor Signaling by c-Cbl/Sli-1
Molecular Cell, Volume 4, Issue 6, December 1999, Pages 1029-1040
Gil Levkowitz, Hadassa Waterman, Seth A. Ettenberg, Menachem Katz, Alexander Y. Tsygankov, Iris Alroy, Sara Lavi, Kazuhiro Iwai, Yuval Reiss, Aaron Ciechanover et al.
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Inhibition of ubiquitin-proteasome dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus (EBV) nuclear antigen (EBNA)-1  
Immunology Letters, Volume 56, Part 2, May 1997, Page 438
Jelena Levitskaya, Anatoly Sharipo, Aaron Ciechanover and Maria G. Masucci
 PDF (179 K)        Abstract via ScienceDirect

On the involvement of calpains in the degradation of the tumor suppressor protein p53  
FEBS Letters, Volume 406, Issues 1-2, 7 April 1997, Pages 17-22
Hedva Gonen, Dganit Shkedy, Sivia Barnoy, Nechama S. Kosower and Aaron Ciechanover
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Degradation of tyrosine aminotransferase (TAT) via the ubiquitin–proteasome pathway  
FEBS Letters, Volume 405, Issue 2, 24 March 1997, Pages 175-180
Shlomit Gross-Mesilaty, James L. Hargrove and Aaron Ciechanover
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Characterization of ubiquitin genes and -transcripts and demonstration of a ubiquitin-conjugating system in Entamoeba histolytica  
Molecular and Biochemical Parasitology, Volume 82, Issue 1, 12 November 1996, Pages 81-90
Claudia Wöstmann, Dimitris Liakopoulos, Aaron Ciechanover and Tilly Bakker-Grunwald
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The 26S proteasome of the yeast Saccharomyces cerevisiae
FEBS Letters, Volume 355, Issue 1, 21 November 1994, Pages 69-75
Michael Fischer, Wolfgang Hilt, Birgit Richter-Ruoff, Hedva Gonen, Aaron Ciechanover and Dieter H. Wolf
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The ubiquitin-proteasome proteolytic pathway  
Cell, Volume 79, Issue 1, 7 October 1994, Pages 13-21
Aaron Ciechanover
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Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system
FEBS Letters, Volume 348, Issue 2, 11 July 1994, Pages 126-130
Dganit Shkedy, Hedva Gonen, Beatrice Bercovich and Aaron Ciechanover
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A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes  Biochemical and Biophysical Research Communications, Volume 81, Issue 4, 28 April 1978, Pages 1100-1105
Aharon Ciechanover, Yaacov Hod and Avram Hershko
 PDF (401 K)