Tech specs & Downloads

Reaxys/Reaxys Medicinal Chemistry is a unique web-based chemistry database consisting of deeply excerpted compounds and related factual properties, reaction and synthesis information as well as bibliographic data, navigated and displayed via an actionable interface.

Counts of the various types of content in the database can be found here: About Reaxys

Tested Environments

Please Note: Reaxys/Reaxys Medicinal Chemistry is a web-based application using JavaScript and Java applets to support various structure and reaction query editors. As such it may run on all platforms which support Java 1.5 or higher and JavaScript execution. However, we have tested and certified Reaxys on the platforms and browsers mentioned in the table below to ensure that all features run in those environments. Using Reaxys in other environments may result in some limitations of functionality.

Windows PC Macintosh PC
Operating system
Windows 2000
Windows Vista
Windows 7

Please note: with Microsoft ceasing the support of Windows XP Reaxys is not test on this platform any longer.
Mac OS X 10.4 or higher
Internet Browser Software
Please note: We cease the support of Microsoft Internet Explorer 6.x and Mozilla FireFox 3.x with the next Reaxys release in 2014. While we expect Reaxys to run with those browsers, certain features may not be supported.

Microsoft Internet Explorer 7
Microsoft Internet Explorer 8 (with Java 1.6.0_11 or higher)
Microsoft Internet Explorer 9-11

Mozilla Firefox 3 to 3.5
Mozilla Firefox 3.6 (with Java 1.6.0_11 or higher;)
Mozilla Firefox 4 or higher

Google Chrome 10 or higher

Note: JavaScript and cookies need to be enabled.
Please note: We cease the support of Mozilla FireFox 3.x with the next Reaxys release in 2014. While we expect Reaxys to run with those browsers, certain features may not be supported.

Safari 4.0 or higher (Safari 3 is no longer being tested)

Mozilla Firefox 3.x
Mozilla Firefox 4 or higher

Google Chrome 10 or higher

Note: JavaScript and cookies need to be enabled.
Java Runtime Environment (JRE)
Sun Microsystems Java Version 5.0 or later also known as Java Runtime Environment (JRE) Version 1.5.0 (with external editors (see below) Java 4 is also supported).

Note1: Java security settings must be changed from "High" to "Medium" for the Java version 1.7.0_45 in order to transfer drawn structure from java-required sturcture editors(MarvinSketch, Accelrys/ISISDraw, ChemDraw) to Reaxys. This is not required with Java version 1.7.0_51 and above.

Note 2: Reaxys was tested with the latest Java versions 1.6 and our QA team found some severe issues with the update 10 of this Java version. Therefore we do not recommend using Java 1.6.0_10. Please update to a later version of Java, e.g. build 13 or higher, where the Java issues have been fixed by Sun.

Note 3: Java needs to be enabled in the browser.

Recommendation: you may use the following website provided by SUN to check whether Java is correctly installed or not.
Apple Java Runtime Environment (JRE) 5.0 or higher

Note 1: This website provides an overview on available Java versions for different Mac OS X 10 environments. In case of any issues regarding Java on a Macintosh please either contact our customer care team.
We also recommend to checkout the following webpage.
Supported Structure Editors
Java-free Editors:
- Elemental (Dotmatics; embedded editor)
- Ketcher (GGA; embedded editor)

Editors requiring Java:
Important note: please change the security settings for Java version 1.7.0_45 for the editor to work properly (see above)
- MarvinSketch (ChemAxon; embedded editor)
- ISIS/Draw (Accelrys; up to version 2.5)
- Accelrys/Symyx Draw (Accelrys; up to version 4.1)
- CrossFire Structure Editor (Elsevier; up to version 7)
- ChemDraw Pro 12 (CambridgeSoft; please note: the connector to Reaxys has been developed and is being maintained by CambridgeSoft. Please contact CambridgeSoft support in case of any issues.)
- ICEdit (InfoChem; please note: the connector to Reaxys has been developed and is being maintained by InfoChem. Please contact InfoChem support in case of any issues.)

Note 1: If other editors than MarvinSketch, Elemental or Ketcher are used, a plug-in has to be installed, which can be downloaded here.
After downloading the archive simply start one of the installers and follow the instructions.
- Elemental (Dotmatics; see also left colum)
- MarvinSketch (ChemAxon; see also left column)
- ChemDraw 12 on Mac OS 10.5 or higher (CambridgeSoft; please note ChemDraw Std and BioDraw Ultra are not supported)
The Reaxys output feature supports the export of Reaxys data into Microsoft Word and Microsoft Excel formats. Please note that the created files requires Microsoft Word, Excel or Office Version 2003 or higher.


What is Reaxys?

Reaxys is an online workflow solution for research chemists. It supports research and fuels discovery by integrating searches for experimentally validated – not calculated - reaction and substance data with synthesis planning and chemical sources so less time is spent interrogating results and evaluating alternative synthetic routes.
Easy access to relevant and actionable results means chemists can move more quickly through their workflow steps to deliver superior outcomes. Reaxys enhances the exploration of chemical reaction and substance information, giving chemists more time for creativity and innovation.

What does Reaxys cover?

Historical data dating back to 1771 and coverage of the most important current journal and patents within chemistry ensure that Reaxys provides a unified source for reaction and substance data. Chemists no longer have to waste time accumulating data manually. The data excerpted from the journals and patents meets carefully controlled selection criteria – namely that all organic, inorganic and organometallic properties and data are excerpted only if they have a structure, experimental fact and a credible citation, allowing a deep dive into the chemical data.

Who can benefit from Reaxys?

Reaxys is an integral part of the research chemist's workflow, supporting today's multi-disciplinary approach to modern research. Irrespective of the area of chemistry – organic, medicinal, synthetic, agro/fine/catalyst, inorganic, process, to name a few – Reaxys provides relevant information and tools. It enables scientists to move from a basic idea to target compound, to evaluate/optimize alternative synthetic routes, to identify and combine selected reaction solutions for research chemists, and to support research and task-based learning through experimentally validated substance data search. Reaxys helps improve the research chemistry workflow significantly, giving the relevant, experimentally validated data needed to move research forward.

Does Reaxys require installations? Or is Reaxys a web-based product?

Reaxys is a platform independent, web-based product, so it doesn't require any installation efforts. If you wish to operate in a Java-free environment you should ensure that either GGA Ketcher or Elemental are your default editors. If you wish to run any other structure editor, Java version 1.5 or higher is a prerequisite.
Customers can access the product at Platform independency means that it runs on Windows and Apple operating systems. We support Internet Explorer (6 or higher), Firefox (3 or higher) and Safari (4 or higher. Technical requirements are available in the Tech specs and Download section.

May I have a demonstration of Reaxys free of charge?

Yes – please contact sales.

Is a username or password needed to access Reaxys?

We offer CWA-licenses (Corporate/Campus Wide Access) flat-rate on a yearly subscription base including user authentication via IP-recognition. So no credentials needed here; no seat-based delays or budgetary concerns about task-based searches. Reaxys is also web-based, so chemists can access it anytime and anywhere.

Does Reaxys support user authentication through Shibboleth or ATHENS?

Reaxys currently supports Shibboleth but not ATHENS.

Is it possible to link to full-texts of journals and patent publications?

Yes. The full text link is Reaxys gives direct access to the publisher home pages including ScienceDirect (world's largest electronic collection of science, technology and medicine full-text and bibliographic information – owned by Elsevier) and EspaceNet (European Patent Office) and US Patent Office. Access to ScienceDirect and literature publisher requires a subscription licence. EspaceNet and USPTO are publicly available.

Is linking to Scopus possible?

Yes. Reaxys provides links to and from Scopus for all matching articles.

Does Reaxys provide commercial availability data and supplier information? If so, which and how?

Elsevier has matched the Reaxys compounds with three databases containing information about commercial availability: eMolecules, CambridgeSoft ACX, and Accelrys ACD (Available Chemicals Directory).
In case of a successful match, icons are displayed by the compound within the Reaxys interface and a click on such an icon leads to the corresponding service. Please note: access to ACD and ACX data is provided through Accelrys and CambridgeSoft and requires separate licensing. All the relevant commercial information, including quantity, pricing and vendor information is available within the research workflow.

How does Reaxys deal with firewall security?

Security is one of our biggest concerns and therefore Reaxys is accessible using HTTPS protocol. This requires port 443 to be open in a company's firewall. Since this is a standard setting, it should not be a problem, unless the company prohibits all internet access.

What is the default structure editor in Reaxys? Which other structure editors does Reaxys support?

Reaxys supports the following structure editors:

Dotmatics Elemental – default structure editor
GGA Ketcher
Marvin Sketch (ChemAxon)
ISIS/Draw (Accelrys)
Symyx Draw (Accelrys)
ChemDraw Pro or higher (CambridgeSoft)
ICEdit (InfoChem)
CrossFire Structure Editor (Elsevier)
Please note: if you wish to use structure editors other than Elemental, Marvin Sketch, or GGA Ketcher, a plug-in has to be installed. This can be downloaded here. Please refer to Reaxys' help' for more information on this topic.

Can I still use the CrossFire Structure Editor?

Reaxys was designed to accommodate a number of industry standard structure editors (both Macintosh and PC supported). We will continue to support the CrossFire Structure Editor for the following year, but we will not be further developing or maintaining it, therefore it is recommended that you switch to one of the many other available editors.
Please note that if you wish to continue to use the CrossFire Structure Editor until it is discontinued, you or your information specialist must not uninstall CrossFire Commander – this must remain installed for the CrossFire Structure Editor to work. If you have specific questions or preferences for structure editor features please don't hesitate to contact us at

Can customers link Reaxys with an in-house repository?

Yes. Please contact us for more information.

Do CWA and web-based access also allow for individual saved searches?

Reaxys has this functionality. To allow the user to change the application settings, save queries and search history and set up alerts, s/he can set his/her own username/password by using REGISTER in Reaxys. Afterwards login queries can be loaded and saved locally on the workstation and results can be saved.

How do I access training and support for Reaxys?

In order to provide a superior user experience, Elsevier provides robust multichannel support. From within Reaxys, customers have 24/7 access to on-line self-service support and training materials, including training guides, work flow examples and an FAQ knowledgebase, to provide guidance through the entire user experience. In addition, our Customer Care team stands ready to assist you through phone or email with any additional or unique questions you may have. Helping you to have a very positive and productive experience with Elsevier's products is our highest priority.



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