Metabolizing Enzymes and Transporters Module
Leading drug discovery researchers choose the PharmaPendium Metabolizing Enzymes and Transporters Module for accurate assessments of drug candidates and their interactions with other enzymes and other drugs.
- Access the greatest source of drug-metabolizing enzyme data
- Accurately predict drug-drug interactions
- Make key risk assessments on bioavailability, toxicity and more
- Predict adverse effects early and save research time and money
- Benefit from relevant search filters and categories
Metabolizing Enzymes and Transporters in focus
Understanding Key Determinants of Drug Activity
Dr. Kevin Lustig and Dr. Maria Thompson describe the impact of metabolizing enzymes and transporter protein research on the cost and quality of clinical drug development.
What Drug Interactions Have I Missed?
Read more about the features and benefits of PharmaPendium’s Metabolizing Enzymes and Transporters Module in our special product profile.
Supporting you with assessments at every stage of drug development
The Metabolizing Enzymes and Transporters Module can give you confidence in your drug candidate assessment. It contains more data on drug-metabolizing enzymes and transporters and drug-drug interactions than any other database. The module helps you to more accurately predict DDIs under various conditions and with different subtypes and assemble improved DDI modeling sets to identify potential problems. It supports you with prioritizing the most promising candidates and gives access to detailed metabolizing enzyme and transporter studies on approved drugs. Benefit from the powerful support of the Metabolizing Enzymes and Transporters Module for preclinical, clinical and safety assessment.
The Metabolizing Enzyme and Transporters Story
Watch this exclusive video about drug-drug and drug-enzyme interactions and see how PharmaPendium’s Metabolizing Enzymes and Transporters Module can fit into your workflow.
Thorough Drug Candidate Assessments
Incredibly detailed comparative data for confident drug candidate assessments
Drug candidates undergo multiple assessments during the development process. The Metabolizing Enzymes and Transporters Module allows you to compare data in various ways, enabling you to ascertain your drug candidate’s potential. Assess possible drug-drug interactions based on similarities with the targets, class, common adverse effects and structure of other drugs. Make risk assessments on key topics, such as drug interaction-induced toxicity and CYP interaction-induced changes in bioavailability. The Metabolizing Enzyme can do all this and more, including giving you insight into regulatory submission issues that have arisen for similar drugs, such as supplementary study requirements.
Uncover potential DDIs
Save time and money with early discovery of potential issues
Early discovery of critical drug-drug interactions that might lead to a lack of efficacy or a serious adverse event is crucial. The Metabolizing Enzymes and Transporters Module makes such discoveries more likely. It extracts data from a comprehensive regulatory sources and journals (transporters only). This information can help users avoid late-stage drug failures due to unexpected changes in bioavailability, potentially saving millions of dollars in research and development costs. Make such predictions with confidence thanks to the Metabolizing Enzymes and Transporters Module.
Early discovery of critical drug-drug interactions that might lead to a lack of efficacy or a serious adverse event is crucial. The Metabolizing Enzymes and Transporters Module makes such discoveries more likely, it extracts data from comprehensive regulatory sources. This information can help you avoid late-stage drug failures due to unexpected changes in bioavailability, potentially saving you millions of dollars in research and development costs. Make such predictions with confidence thanks to the Metabolizing Enzymes and Transporters Module.
Intelligent Search Functions
Search terms and filters that give you more refined searching power
The Metabolizing Enzymes and Transporters Module is an indispensable tool for assessing drug candidates. It is designed to give you the possibility to refine your search results and highlight what is most important to your research. You can search for key parameters and experimental conditions and apply filters to refine the results. You also have the option to sort your results under multiple conditions. These include:
- Drug name
- Metabolites created
- CYPs
- Phase 2 Enzymes
- Dynamic pharmokinetics parameters
o Cint (Intrinsic Clearance)
o Km (Michaelis Constant)
o Vmax (maximum rate of enzyme reaction) - Transporters and effects on transporters
- Drug role (as substrate, inducer or inhibitor)
- DDIs
- Concomitant drugs
- Dose
- Route
- Species
The Metabolizing Enzymes and Transporters Module is an indispensable tool for assessing drug candidates. It is designed to give you the possibility to refine your search results and highlight what is most important to your research. You can search for key parameters and experimental conditions and apply filters to refine the results. You also have the option to sort your results under multiple conditions. These include metabolites created, CYPs, dynamic pharmokinetics parameters such as Cint, Km and Vmax, drug-drug interactions, and drug role.
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