Top 25 Hottest Biochemistry Articles

Hallmarks of Cancer: The Next Generation • Review article
Cell, Volume 144, Issue 5, March 2011, Pages 646-674 | Hanahan, D.; Weinberg, Robert A.

Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos • Article
Cell, Volume 156, Issue 4, February 2014, Pages 836-843 | Niu, Y.; Shen, B.; Cui, Y.; Chen, Y.; Wang, J.; Wang, L.; Kang, Y.; Zhao, X.; Si, W.; Li, W.; Xiang, A.; Zhou, J.; Guo, X.; Bi, Y.; Si, C.; Hu, B.; Dong, G.; Wang, H.; Zhou, Z.; Li, T.; Tan, T.; Pu, X.; Wang, F.; Ji, S.; Zhou, Q.; Huang, X.; Ji, W.; Sha,

Hydrolysis of lignocellulosic materials for ethanol production: a review • Article
Bioresource Technology, Volume 83, Issue 1, May 2002, Pages 1-11 | Sun, Y.; Cheng, J.

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA • Article
Cell, Volume 156, Issue 5, February 2014, Pages 935-949 | Nishimasu, H.; Ran, F.; Hsu, Patrick D.; Konermann, S.; Shehata, Soraya I.; Dohmae, N.; Ishitani, R.; Zhang, F.; Nureki, O.

Dynamic Imaging of Genomic Loci in Living Human Cells by an Optimized CRISPR/Cas System • Article
Cell, Volume 155, Issue 7, December 2013, Pages 1479-1491 | Chen, B.; Gilbert, Luke A.; Cimini, Beth A.; Schnitzbauer, J.; Zhang, W.; Li, G.W.; Park, J.; Blackburn, Elizabeth H.; Weissman, Jonathan S.; Qi, Lei S.; Huang, B.

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering • Review article
Trends in Biotechnology, Volume 31, Issue 7, July 2013, Pages 397-405 | Gaj, T.; Gersbach, C.A.; Barbas, C.F.

Declining NAD^+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging • Article
Cell, Volume 155, Issue 7, December 2013, Pages 1624-1638 | Gomes, Ana P.; Price, Nathan L.; Ling, Alvin J.Y.; Moslehi, Javid J.; Montgomery, M.K.; Rajman, L.; White, James P.; Teodoro, Joao S.; Wrann, Christiane D.; Hubbard, Basil P.; Mercken, Evi M.; Palmeira, Carlos M.; de Cabo, R.; Rolo, Anabela P.; Turner, N.

One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering • Article
Cell, Volume 153, Issue 4, May 2013, Pages 910-918 | Wang, H.; Yang, H.; Shivalila, Chikdu S.; Dawlaty, Meelad M.; Cheng, Albert W.; Zhang, F.; Jaenisch, R.

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors • Article
Cell, Volume 126, Issue 4, August 2006, Pages 663-676 | Takahashi, K.; Yamanaka, S.

Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders • Article
Cell, Volume 155, Issue 7, December 2013, Pages 1451-1463 | Hsiao, Elaine Y.; McBride, Sara W.; Hsien, S.; Sharon, G.; Hyde, Embriette R.; McCue, T.; Codelli, Julian A.; Chow, J.; Reisman, Sarah E.; Petrosino, Joseph F.; Patterson, Paul H.; Mazmanian, Sarkis K.

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity • Article
Cell, Volume 154, Issue 6, September 2013, Pages 1380-1389 | Ran, F.; Hsu, Patrick D.; Lin, C.Y.; Gootenberg, Jonathan S.; Konermann, S.; Trevino, A.E.; Scott, David A.; Inoue, A.; Matoba, S.; Zhang, Y.; Zhang, F.

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering • Article
Cell, Volume 154, Issue 6, September 2013, Pages 1370-1379 | Yang, H.; Wang, H.; Shivalila, Chikdu S.; Cheng, Albert W.; Shi, L.; Jaenisch, R.

Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions • Review article
Cell, Volume 156, Issue 1-2, January 2014, Pages 45-68 | Wu, H.; Zhang, Y.

Premature Termination of Reprogramming In Vivo Leads to Cancer Development through Altered Epigenetic Regulation • Article
Cell, Volume 156, Issue 4, February 2014, Pages 663-677 | Ohnishi, K.; Semi, K.; Yamamoto, T.; Shimizu, M.; Tanaka, A.; Mitsunaga, K.; Okita, K.; Osafune, K.; Arioka, Y.; Maeda, T.; Soejima, H.; Moriwaki, H.; Yamanaka, S.; Woltjen, K.; Yamada, Y.

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits • Article
Cell, Volume 156, Issue 1-2, January 2014, Pages 84-96 | De Vadder, F.; Kovatcheva-Datchary, P.; Goncalves, D.; Vinera, J.; Zitoun, C.; Duchampt, A.; Backhed, F.; Mithieux, G.

Mechanism of surfactant effect in enzymatic hydrolysis of lignocellulose • Article
Enzyme and Microbial Technology, Volume 31, Issue 3, August 2002, Pages 353-364 | Eriksson, T.; Borjesson, J.; Tjerneld, F.

Epigenetic Priming of Memory Updating during Reconsolidation to Attenuate Remote Fear Memories • Article
Cell, Volume 156, Issue 1-2, January 2014, Pages 261-276 | Graff, J.; Joseph, Nadine F.; Horn, Meryl E.; Samiei, A.; Meng, J.; Seo, J.; Rei, D.; Bero, Adam W.; Phan, Trongha X.; Wagner, F.; Holson, E.; Xu, J.; Sun, J.; Neve, Rachael L.; Mach, Robert H.; Haggarty, Stephen J.; Tsai, L.H.

The Hallmarks of Cancer • Review article
Cell, Volume 100, Issue 1, January 2000, Pages 57-70 | Hanahan, D.; Weinberg, R.A.

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis • Article
Cell, Volume 156, Issue 5, February 2014, Pages 1002-1016 | Valiente, M.; Obenauf, Anna C.; Jin, X.; Chen, Q.; Zhang, Xiang H.F.; Lee, Derek J.; Chaft, Jamie E.; Kris, Mark G.; Huse, Jason T.; Brogi, E.; Massague, J.

Hippo Signaling Regulates Microprocessor and Links Cell-Density-Dependent miRNA Biogenesis to Cancer • Article
Cell, Volume 156, Issue 5, February 2014, Pages 893-906 | Mori, M.; Triboulet, R.; Mohseni, M.; Schlegelmilch, K.; Shrestha, K.; Camargo, Fernando D.; Gregory, Richard I.

Neurogenesis in the Striatum of the Adult Human Brain • Article
Cell, Volume 156, Issue 5, February 2014, Pages 1072-1083 | Ernst, A.; Alkass, K.; Bernard, S.; Salehpour, M.; Perl, S.; Tisdale, J.; Possnert, G.; Druid, H.; Frisen, J.

Cannabidiol protects liver from binge alcohol-induced steatosis by mechanisms including inhibition of oxidative stress and increase in autophagy • Article
Free Radical Biology and Medicine, Volume 68, March 2014, Pages 260-267 | Yang, L.; Rozenfeld, R.; Wu, D.; Devi, L.A.; Zhang, Z.; Cederbaum, A.

The Bacterial Cytoplasm Has Glass-like Properties and Is Fluidized by Metabolic Activity • Article
Cell, Volume 156, Issue 1-2, January 2014, Pages 183-194 | Parry, Bradley R.; Surovtsev, Ivan V.; Cabeen, Matthew T.; O\'Hern, Corey S.; Dufresne, Eric R.; Jacobs-Wagner, C.

Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program • Article
Cell, Volume 155, Issue 7, December 2013, Pages 1639-1651 | Cheung, Kevin J.; Gabrielson, E.; Werb, Z.; Ewald, Andrew J.

Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation • Article
Cell, Volume 155, Issue 7, December 2013, Pages 1507-1520 | Kieffer-Kwon, K.R.; Tang, Z.; Mathe, E.; Qian, J.; Sung, M.H.; Li, G.; Resch, W.; Baek, S.; Pruett, N.; Grontved, L.; Vian, L.; Nelson, S.; Zare, H.; Hakim, O.; Reyon, D.; Yamane, A.; Nakahashi, H.; Kovalchuk, Alexander L.; Zou, J.; Joung, J.; Sartorelli,