Top 25 Hottest Biochemistry Articles

Hallmarks of Cancer: The Next Generation • Review article
Cell, Volume 144, Issue 5, March 2011, Pages 646-674 | Hanahan, D.; Weinberg, Robert A.

Development and Applications of CRISPR-Cas9 for Genome Engineering • Review article
Cell, Volume 157, Issue 6, June 2014, Pages 1262-1278 | Hsu, Patrick D.; Lander, Eric S.; Zhang, F.

Comparison of aroma active and sulfur volatiles in three fragrant rice cultivars using GC-Olfactometry and GC-PFPD • Article
Food Chemistry, Volume 154, July 2014, Pages 1-6 | Mahattanatawee, K.; Rouseff, R.L.

Single-Cell Phenotyping within Transparent Intact Tissue through Whole-Body Clearing • Article
Cell, Volume 158, Issue 4, August 2014, Pages 945-958 | Yang, B.; Treweek, Jennifer B.; Kulkarni, Rajan P.; Deverman, Benjamin E.; Chen, C.K.; Lubeck, E.; Shah, S.; Cai, L.; Gradinaru, V.

YAP/TAZ Incorporation in the @b-Catenin Destruction Complex Orchestrates the Wnt Response • Article
Cell, Volume 158, Issue 1, July 2014, Pages 157-170 | Azzolin, L.; Panciera, T.; Soligo, S.; Enzo, E.; Bicciato, S.; Dupont, S.; Bresolin, S.; Frasson, C.; Basso, G.; Guzzardo, V.; Fassina, A.; Cordenonsi, M.; Piccolo, S.

CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling • Article
Cell, Volume 159, Issue 2, October 2014, Pages 440-455 | Platt, Randall J.; Chen, S.; Zhou, Y.; Yim, Michael J.; Swiech, L.; Kempton, Hannah R.; Dahlman, James E.; Parnas, O.; Eisenhaure, Thomas M.; Jovanovic, M.; Graham, Daniel B.; Jhunjhunwala, S.; Heidenreich, M.; Xavier, Ramnik J.; Langer, R.; Anderson, Dan

KRAS and YAP1 Converge to Regulate EMT and Tumor Survival • Article
Cell, Volume 158, Issue 1, July 2014, Pages 171-184 | Shao, Diane D.; Xue, W.; Krall, Elsa B.; Bhutkar, A.; Piccioni, F.; Wang, X.; Schinzel, Anna C.; Sood, S.; Rosenbluh, J.; Kim, Jong W.; Zwang, Y.; Roberts, Thomas M.; Root, David E.; Jacks, T.; Hahn, William C.

Metal-organic coordination polymers based on imidazolyl- and benzimidazolyl-containing 4,4'-bipy typeligands • Article
Journal of Molecular Structure, Volume 1052, November 2013, Pages 146-157 | Jin, G.X.; Ma, J.P.; Dong, Y.B.

Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors • Article
Cell, Volume 126, Issue 4, August 2006, Pages 663-676 | Takahashi, K.; Yamanaka, S.

The Hallmarks of Cancer • Review article
Cell, Volume 100, Issue 1, January 2000, Pages 57-70 | Hanahan, D.; Weinberg, R.A.

A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation • Article
Cell, Volume 158, Issue 1, July 2014, Pages 84-97 | Sutendra, G.; Kinnaird, A.; Dromparis, P.; Paulin, R.; Stenson, Trevor H.; Haromy, A.; Hashimoto, K.; Zhang, N.; Flaim, E.; Michelakis, Evangelos D.

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis • Article
Cell, Volume 158, Issue 5, August 2014, Pages 1110-1122 | Aceto, N.; Bardia, A.; Miyamoto, David T.; Donaldson, Maria C.; Wittner, Ben S.; Spencer, Joel A.; Yu, M.; Pely, A.; Engstrom, A.; Zhu, H.; Brannigan, Brian W.; Kapur, R.; Stott, Shannon L.; Shioda, T.; Ramaswamy, S.; Ting, David T.; Lin, Charles P.; Tone

H3K4me3 Breadth Is Linked to Cell Identity and Transcriptional Consistency • Article
Cell, Volume 158, Issue 3, July 2014, Pages 673-688 | Benayoun, Berenice A.; Pollina, Elizabeth A.; Ucar, D.; Mahmoudi, S.; Karra, K.; Wong, Edith D.; Devarajan, K.; Daugherty, Aaron C.; Kundaje, Anshul B.; Mancini, E.; Hitz, Benjamin C.; Gupta, R.; Rando, Thomas A.; Baker, Julie C.; Snyder, Michael P.; Cher

Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development • Article
Cell, Volume 158, Issue 2, July 2014, Pages 263-276 | Bernier, R.; Golzio, C.; Xiong, B.; Stessman, Holly A.; Coe, Bradley P.; Penn, O.; Witherspoon, K.; Gerdts, J.; Baker, C.; Vulto-van Silfhout, Anneke T.; Schuurs-Hoeijmakers, Janneke H.; Fichera, M.; Bosco, P.; Buono, S.; Alberti, A.; Failla, P.; Peeters,

CellNet: Network Biology Applied to Stem Cell Engineering • Article
Cell, Volume 158, Issue 4, August 2014, Pages 903-915 | Cahan, P.; Li, H.; Morris, Samantha A.; Lummertz da Rocha, E.; Daley, George Q.; Collins, James J.

MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation • Article
Cell, Volume 158, Issue 3, July 2014, Pages 607-619 | Zhang, X.; Zuo, X.; Yang, B.; Li, Z.; Xue, Y.; Zhou, Y.; Huang, J.; Zhao, X.; Zhou, J.; Yan, Y.; Zhang, H.; Guo, P.; Sun, H.; Guo, L.; Zhang, Y.; Fu, X.D.

Starvation-Induced Transgenerational Inheritance of Small RNAs in C. elegans • Article
Cell, Volume 158, Issue 2, July 2014, Pages 277-287 | Rechavi, O.; Houri-Ze\'evi, L.; Anava, S.; Goh, W.; Kerk, S.; Hannon, Gregory J.; Hobert, O.

Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer • Article
Cell, Volume 158, Issue 1, July 2014, Pages 185-197 | Kapoor, A.; Yao, W.; Ying, H.; Hua, S.; Liewen, A.; Wang, Q.; Zhong, Y.; Wu, C.J.; Sadanandam, A.; Hu, B.; Chang, Q.; Chu, Gerald C.; Al-Khalil, R.; Jiang, S.; Xia, H.; Fletcher-Sananikone, E.; Lim, C.; Horwitz, Gillian I.; Viale, A.; Pettazzoni, P.; Sanc

Natural Neural Projection Dynamics Underlying Social Behavior • Article
Cell, Volume 157, Issue 7, June 2014, Pages 1535-1551 | Gunaydin, Lisa A.; Grosenick, L.; Finkelstein, Joel C.; Kauvar, Isaac V.; Fenno, Lief E.; Adhikari, A.; Lammel, S.; Mirzabekov, Julie J.; Airan, Raag D.; Zalocusky, Kelly A.; Tye, Kay M.; Anikeeva, P.; Malenka, Robert C.; Deisseroth, K.

Using Targeted Chromatin Regulators to Engineer Combinatorial and Spatial Transcriptional Regulation • Article
Cell, Volume 158, Issue 1, July 2014, Pages 110-120 | Keung, Albert J.; Bashor, Caleb J.; Kiriakov, S.; Collins, James J.; Khalil, Ahmad S.

Autism-Associated Neuroligin-3 Mutations Commonly Impair Striatal Circuits to Boost Repetitive Behaviors • Article
Cell, Volume 158, Issue 1, July 2014, Pages 198-212 | Rothwell, Patrick E.; Fuccillo, Marc V.; Maxeiner, S.; Hayton, Scott J.; Gokce, O.; Lim, B.; Fowler, Stephen C.; Malenka, Robert C.; Sudhof, Thomas C.

Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia • Article
Cell, Volume 158, Issue 3, July 2014, Pages 593-606 | Trimarchi, T.; Bilal, E.; Ntziachristos, P.; Fabbri, G.; Dalla-Favera, R.; Tsirigos, A.; Aifantis, I.

Drug Resistance via Feedback Activation of Stat3 in Oncogene-Addicted Cancer Cells • Article
Cancer Cell, Volume 26, Issue 2, August 2014, Pages 207-221 | Lee, H.J.; Zhuang, G.; Cao, Y.; Du, P.; Kim, H.J.; Settleman, J.

A Systematic Analysis of Biosynthetic Gene Clusters in the Human Microbiome Reveals a Common Family of Antibiotics • Article
Cell, Volume 158, Issue 6, September 2014, Pages 1402-1414 | Donia, Mohamed S.; Cimermancic, P.; Schulze, Christopher J.; Wieland Brown, Laura C.; Martin, J.; Mitreva, M.; Clardy, J.; Linington, Roger G.; Fischbach, Michael A.

Heme Oxygenase-1 Drives Metaflammation and Insulin Resistance in Mouse and Man • Article
Cell, Volume 158, Issue 1, July 2014, Pages 25-40 | Jais, A.; Einwallner, E.; Sharif, O.; Gossens, K.; Lu, T.H.; Soyal, Selma M.; Medgyesi, D.; Neureiter, D.; Paier-Pourani, J.; Dalgaard, K.; Duvigneau, J.; Lindroos-Christensen, J.; Zapf, T.C.; Amann, S.; Saluzzo, S.; Jantscher, F.; Stiedl, P.; Todoric, J.