Structure
Form and function in modern biology
Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding and/or design, will also be considered favorably. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single molecule analysis of biological mechanisms are welcome. In general, the editors encourage submission of structural studies that are validated by additional experimental systems that address structure-activity relationships, and will not consider studies that solely report structural information unless the structure under investigation is of exceptional and broad interest.
Visit the Structure website to find out more - http://www.structure.org
Editors: Christopher D. Lima , Andrej Sali
Impact factor: 5.994
5 year impact factor: 6.081
Imprint: Cell Press
ISSN: 0969-2126
Most cited
Top 10 Cited (articles published in the last five years)
Extracted from Scopus (on Sun Jun 30)287 Hanson, M.A. | Cherezov, V. | Griffith, M.T. | Roth, C.B. | Jaakola, V.-P. | Chien, E.Y.T. | Velasquez, J. | Kuhn, P. | Stevens, R.C. A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor Structure, Volume 16, Issue 6, 2008-06-11, Pages 897-905 142 Trabuco, L.G. | Villa, E. | Mitra, K. | Frank, J. | Schulten, K. Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics Structure, Volume 16, Issue 5, 2008-05-07, Pages 673-683 115 Cheng, X. | Blumenthal, R.M. Mammalian DNA Methyltransferases: A Structural Perspective Structure, Volume 16, Issue 3, 2008-03-11, Pages 341-350 112 Mobley, D.L. | Dill, K.A. Binding of Small-Molecule Ligands to Proteins: "What You See" Is Not Always "What You Get" Structure, Volume 17, Issue 4, 2009-04-15, Pages 489-498 110 del Sol, A. | Tsai, C.-J. | Ma, B. | Nussinov, R. The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways Structure, Volume 17, Issue 8, 2009-08-12, Pages 1042-1050 108 Hanson, M.A. | Stevens, R.C. Discovery of New GPCR Biology: One Receptor Structure at a Time Structure, Volume 17, Issue 1, 2009-01-14, Pages 8-14 107 Henne, W.M. | Kent, H.M. | Ford, M.G.J. | Hegde, B.G. | Daumke, O. | Butler, P.J.G. | Mittal, R. | Langen, R. | Evans, P.R. | McMahon, H.T. Structure and Analysis of FCHo2 F-BAR Domain: A Dimerizing and Membrane Recruitment Module that Effects Membrane Curvature Structure, Volume 15, Issue 7, 2007-07-18, Pages 839-852 95 Ludtke, S.J. | Baker, M.L. | Chen, D.-H. | Song, J.-L. | Chuang, D.T. | Chiu, W. De Novo Backbone Trace of GroEL from Single Particle Electron Cryomicroscopy Structure, Volume 16, Issue 3, 2008-03-11, Pages 441-448 95 Möglich, A. | Ayers, R.A. | Moffat, K. Structure and Signaling Mechanism of Per-ARNT-Sim Domains Structure, Volume 17, Issue 10, 2009-10-14, Pages 1282-1294 92 Topf, M. | Lasker, K. | Webb, B. | Wolfson, H. | Chiu, W. | Sali, A. Protein Structure Fitting and Refinement Guided by Cryo-EM Density Structure, Volume 16, Issue 2, 2008-02-12, Pages 295-307 - View all items
Most downloaded
Most Read Articles - counted by Article downloads on SciVerse ScienceDirect in the period 01 April 2002 to 31 May 2013
Sun Jun 301 Toshimitsu Kawate | Eric Gouaux Fluorescence-Detection Size-Exclusion Chromatography for Precrystallization Screening of Integral Membrane Proteins Structure, Volume 14, Issue 4, April 2006, Pages 673-681 2 Thomas S. Walter | Christoph Meier | Rene Assenberg | Kin-Fai Au | Jingshan Ren | Anil Verma | Joanne E. Nettleship | Raymond J. Owens | David I. Stuart | Jonathan M. Grimes Lysine Methylation as a Routine Rescue Strategy for Protein Crystallization Structure, Volume 14, Issue 11, November 2006, Pages 1617-1622 3 Kenji Kamata | Morihiro Mitsuya | Teruyuki Nishimura | Jun-ichi Eiki | Yasufumi Nagata Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase Structure, Volume 12, Issue 3, March 2004, Pages 429-438 4 Alexander I. Alexandrov | Mauro Mileni | Ellen Y.T. Chien | Michael A. Hanson | Raymond C. Stevens Microscale Fluorescent Thermal Stability Assay for Membrane Proteins Structure, Volume 16, Issue 3, 11 March 2008, Pages 351-359 5 Gideon Davies | Bernard Henrissat Structures and mechanisms of glycosyl hydrolases Structure, Volume 3, Issue 9, September 1995, Pages 853-859 6 Elena Conti | Nick P Franks | Peter Brick Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes Structure, Volume 4, Issue 3, March 1996, Pages 287-298 7 Michael A. Hanson | Vadim Cherezov | Mark T. Griffith | Christopher B. Roth | Veli-Pekka Jaakola | Ellen Y.T. Chien | Jeffrey Velasquez | Peter Kuhn | Raymond C. Stevens A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor Structure, Volume 16, Issue 6, 11 June 2008, Pages 897-905 8 Graeme L. Card | Bruce P. England | Yoshihisa Suzuki | Daniel Fong | Ben Powell | Byunghun Lee | Catherine Luu | Maryam Tabrizizad | Sam Gillette | Prabha N. Ibrahim | Dean R. Artis | Gideon Bollag | Michael V. Milburn | Sung-Hou Kim | Joseph Schlessinger | Kam Y.J. Zhang Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases Structure, Volume 12, Issue 12, December 2004, Pages 2233-2247 9 John R Somoza | Robert J Skene | Bradley A Katz | Clifford Mol | Joseph D Ho | Andy J Jennings | Christine Luong | Andrew Arvai | Joseph J Buggy | Ellen Chi | Jie Tang | Bi-Ching Sang | Erik Verner | Robert Wynands | Ellen M Leahy | Douglas R Dougan | Gyorgy Snell | Marc Navre | Mark W Knuth | Ronald V Swanson | Duncan E McRee | Leslie W Tari Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, Volume 12, Issue 7, July 2004, Pages 1325-1334 10 Istvan Botos | David M. Segal | David R. Davies The Structural Biology of Toll-like Receptors Structure, Volume 19, Issue 4, 13 April 2011, Pages 447-459 - View all items
Recent articles
Sun Jun 301 Greta Hultqvist | S. Raza Haq | Avinash S. Punekar | Celestine N. Chi | Åke Engström | Anders Bach | Kristian Strømgaard | Maria Selmer | Stefano Gianni | Per Jemth Energetic Pathway Sampling in a Protein Interaction Domain Structure, Available online 27 June 2013 2 Matteo T. Degiacomi | Matteo Dal Peraro Macromolecular Symmetric Assembly Prediction Using Swarm Intelligence Dynamic Modeling Structure, Available online 27 June 2013 3 Fabian Kebbel | Mareike Kurz | Marcel Arheit | Markus G. Grütter | Henning Stahlberg Structure and Substrate-Induced Conformational Changes of the Secondary Citrate/Sodium Symporter CitS Revealed by Electron Crystallography Structure, Available online 27 June 2013 4 Kyle C. Dent | Rebecca Thompson | Amy M. Barker | Julian A. Hiscox | John N. Barr | Peter G. Stockley | Neil A. Ranson The Asymmetric Structure of an Icosahedral Virus Bound to Its Receptor Suggests a Mechanism for Genome Release Structure, Available online 27 June 2013 5 D. Sean Froese | Farhad Forouhar | Timothy H. Tran | Melanie Vollmar | Yi Seul Kim | Scott Lew | Helen Neely | Jayaraman Seetharaman | Yang Shen | Rong Xiao | Thomas B. Acton | John K. Everett | Giuseppe Cannone | Sriharsha Puranik | Pavel Savitsky | Tobias Krojer | Ewa S. Pilka | Wasim Kiyani | Wen Hwa Lee | Brian D. Marsden | Frank von Delft | Charles K. Allerston | Laura Spagnolo | Opher Gileadi | Gaetano T. Montelione | Udo Oppermann | Wyatt W. Yue | Liang Tong Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations Structure, Available online 20 June 2013 6 Junsen Tong | Huiseon Yang | Hongyuan Yang | Soo Hyun Eom | Young Jun Im Structure of Osh3 Reveals a Conserved Mode of Phosphoinositide Binding in Oxysterol-Binding Proteins Structure, Available online 20 June 2013 7 Matthew Ling-Hon Chu | Victoria E. Ahn | Hee-Jung Choi | Danette L. Daniels | Roel Nusse | William I. Weis Structural Studies of Wnts and Identification of an LRP6 Binding Site Structure, Available online 20 June 2013 8 Karl R. Schmitz | Atrish Bagchi | Rob C. Roovers | Paul M.P. van Bergen en Henegouwen | Kathryn M. Ferguson Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains Structure, Available online 20 June 2013 9 Franziska Zähringer | Egidio Lacanna | Urs Jenal | Tilman Schirmer | Alex Boehm Structure and Signaling Mechanism of a Zinc-Sensory Diguanylate Cyclase Structure, Available online 13 June 2013 10 Natalia Santos | Jianyu Zhu | John Paul Donohue | Andrei A. Korostelev | Harry F. Noller Crystal Structure of the 70S Ribosome Bound with the Q253P Mutant Form of Release Factor RF2 Structure, Available online 13 June 2013 - View all items

