Form and function in modern biology
Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding and/or design, will also be considered favorably. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single molecule analysis of biological mechanisms are welcome. In general, the editors encourage submission of structural studies that are validated by additional experimental systems that address structure-activity relationships, and will not consider studies that solely report structural information unless the structure under investigation is of exceptional and broad interest.
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Editors: Christopher D. Lima , Andrej Sali
Impact factor: 6.347Impact factor:
© Thomson Reuters Journal Citation Reports 2012
5 year impact factor: 5.931Five-Year Impact Factor:
To calculate the five year Impact Factor, citations are counted in 2012 to the previous five years and divided by the source items published in the previous five years.
© Journal Citation Reports 2012, Published by Thomson Reuters.
Imprint: Cell Press
Top 10 Cited (articles published in the last five years)
Extracted from Scopus (on Fri May 17)
276 Hanson, M.A. | Cherezov, V. | Griffith, M.T. | Roth, C.B. | Jaakola, V.-P. | Chien, E.Y.T. | Velasquez, J. | Kuhn, P. | Stevens, R.C. A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor Structure, Volume 16, Issue 6, 2008-06-11, Pages 897-905 135 Trabuco, L.G. | Villa, E. | Mitra, K. | Frank, J. | Schulten, K. Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics Structure, Volume 16, Issue 5, 2008-05-07, Pages 673-683 112 Cheng, X. | Blumenthal, R.M. Mammalian DNA Methyltransferases: A Structural Perspective Structure, Volume 16, Issue 3, 2008-03-11, Pages 341-350 110 Mobley, D.L. | Dill, K.A. Binding of Small-Molecule Ligands to Proteins: "What You See" Is Not Always "What You Get" Structure, Volume 17, Issue 4, 2009-04-15, Pages 489-498 107 Henne, W.M. | Kent, H.M. | Ford, M.G.J. | Hegde, B.G. | Daumke, O. | Butler, P.J.G. | Mittal, R. | Langen, R. | Evans, P.R. | McMahon, H.T. Structure and Analysis of FCHo2 F-BAR Domain: A Dimerizing and Membrane Recruitment Module that Effects Membrane Curvature Structure, Volume 15, Issue 7, 2007-07-18, Pages 839-852 106 del Sol, A. | Tsai, C.-J. | Ma, B. | Nussinov, R. The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways Structure, Volume 17, Issue 8, 2009-08-12, Pages 1042-1050 106 Hanson, M.A. | Stevens, R.C. Discovery of New GPCR Biology: One Receptor Structure at a Time Structure, Volume 17, Issue 1, 2009-01-14, Pages 8-14 93 Möglich, A. | Ayers, R.A. | Moffat, K. Structure and Signaling Mechanism of Per-ARNT-Sim Domains Structure, Volume 17, Issue 10, 2009-10-14, Pages 1282-1294 92 Ludtke, S.J. | Baker, M.L. | Chen, D.-H. | Song, J.-L. | Chuang, D.T. | Chiu, W. De Novo Backbone Trace of GroEL from Single Particle Electron Cryomicroscopy Structure, Volume 16, Issue 3, 2008-03-11, Pages 441-448 90 Topf, M. | Lasker, K. | Webb, B. | Wolfson, H. | Chiu, W. | Sali, A. Protein Structure Fitting and Refinement Guided by Cryo-EM Density Structure, Volume 16, Issue 2, 2008-02-12, Pages 295-307
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Most Read Articles - counted by Article downloads on SciVerse ScienceDirect in the period 01 April 2002 to 30 April 2013
Fri May 17
1 Toshimitsu Kawate | Eric Gouaux Fluorescence-Detection Size-Exclusion Chromatography for Precrystallization Screening of Integral Membrane Proteins Structure, Volume 14, Issue 4, April 2006, Pages 673-681 2 Thomas S. Walter | Christoph Meier | Rene Assenberg | Kin-Fai Au | Jingshan Ren | Anil Verma | Joanne E. Nettleship | Raymond J. Owens | David I. Stuart | Jonathan M. Grimes Lysine Methylation as a Routine Rescue Strategy for Protein Crystallization Structure, Volume 14, Issue 11, November 2006, Pages 1617-1622 3 Alexander I. Alexandrov | Mauro Mileni | Ellen Y.T. Chien | Michael A. Hanson | Raymond C. Stevens Microscale Fluorescent Thermal Stability Assay for Membrane Proteins Structure, Volume 16, Issue 3, 11 March 2008, Pages 351-359 4 Kenji Kamata | Morihiro Mitsuya | Teruyuki Nishimura | Jun-ichi Eiki | Yasufumi Nagata Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase Structure, Volume 12, Issue 3, March 2004, Pages 429-438 5 Gideon Davies | Bernard Henrissat Structures and mechanisms of glycosyl hydrolases Structure, Volume 3, Issue 9, September 1995, Pages 853-859 6 Elena Conti | Nick P Franks | Peter Brick Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes Structure, Volume 4, Issue 3, March 1996, Pages 287-298 7 Michael A. Hanson | Vadim Cherezov | Mark T. Griffith | Christopher B. Roth | Veli-Pekka Jaakola | Ellen Y.T. Chien | Jeffrey Velasquez | Peter Kuhn | Raymond C. Stevens A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic Receptor Structure, Volume 16, Issue 6, 11 June 2008, Pages 897-905 8 Graeme L. Card | Bruce P. England | Yoshihisa Suzuki | Daniel Fong | Ben Powell | Byunghun Lee | Catherine Luu | Maryam Tabrizizad | Sam Gillette | Prabha N. Ibrahim | Dean R. Artis | Gideon Bollag | Michael V. Milburn | Sung-Hou Kim | Joseph Schlessinger | Kam Y.J. Zhang Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases Structure, Volume 12, Issue 12, December 2004, Pages 2233-2247 9 John R Somoza | Robert J Skene | Bradley A Katz | Clifford Mol | Joseph D Ho | Andy J Jennings | Christine Luong | Andrew Arvai | Joseph J Buggy | Ellen Chi | Jie Tang | Bi-Ching Sang | Erik Verner | Robert Wynands | Ellen M Leahy | Douglas R Dougan | Gyorgy Snell | Marc Navre | Mark W Knuth | Ronald V Swanson | Duncan E McRee | Leslie W Tari Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, Volume 12, Issue 7, July 2004, Pages 1325-1334 10 Istvan Botos | David M. Segal | David R. Davies The Structural Biology of Toll-like Receptors Structure, Volume 19, Issue 4, 13 April 2011, Pages 447-459
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Fri May 17
1 Antti M. Haapalainen | Keisha Thomas | Peter C. Tyler | Gary B. Evans | Steven C. Almo | Vern L. Schramm Salmonella enterica MTAN at 1.36 Å Resolution: A Structure-Based Design of Tailored Transition State Analogs Structure, Available online 16 May 2013 2 Markus-Frederik Bohn | Shivender M.D. Shandilya | John S. Albin | Takahide Kouno | Brett D. Anderson | Rebecca M. McDougle | Michael A. Carpenter | Anurag Rathore | Leah Evans | Ahkillah N. Davis | JingYing Zhang | Yongjian Lu | Mohan Somasundaran | Hiroshi Matsuo | Reuben S. Harris | Celia A. Schiffer Crystal Structure of the DNA Cytosine Deaminase APOBEC3F: The Catalytically Active and HIV-1 Vif-Binding Domain Structure, Available online 16 May 2013 3 Vilas Menon | Brinda K. Vallat | Joseph M. Dybas | Andras Fiser Modeling Proteins Using a Super-Secondary Structure Library and NMR Chemical Shift Information Structure, Available online 16 May 2013 4 James D. Stephenson | Haitao Li | Julia C. Kenyon | Martyn Symmons | Dave Klenerman | Andrew M.L. Lever Three-Dimensional RNA Structure of the Major HIV-1 Packaging Signal Region Structure, Available online 16 May 2013 5 Kutti R. Vinothkumar | Olivier A. Pierrat | Jonathan M. Large | Matthew Freeman Structure of Rhomboid Protease in Complex with β-Lactam Inhibitors Defines the S2𢀲 Cavity Structure, Available online 9 May 2013 6 Xueyong Xu | Xiaoyan Wang | Ying Zhang | Da-Cheng Wang | Jingjin Ding Structural Basis for the Unique Heterodimeric Assembly between Cerebral Cavernous Malformation 3 and Germinal Center Kinase III Structure, Available online 9 May 2013 7 Meera Soundararajan | Annette K. Roos | Pavel Savitsky | Panagis Filippakopoulos | Arminja N. Kettenbach | Jesper V. Olsen | Scott A. Gerber | Jeyanthy Eswaran | Stefan Knapp | Jonathan M. Elkins Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition Structure, Available online 9 May 2013 8 Zhu Pan | Jinwei Zhu | Yuan Shang | Zhiyi Wei | Min Jia | Caihao Xia | Wenyu Wen | Wenning Wang | Mingjie Zhang An Autoinhibited Conformation of LGN Reveals a Distinct Interaction Mode between GoLoco Motifs and TPR Motifs Structure, Available online 9 May 2013 9 Hiromasa Yagi | Kala Bharath Pilla | Ansis Maleckis | Bim Graham | Thomas Huber | Gottfried Otting Three-Dimensional Protein Fold Determination from Backbone Amide Pseudocontact Shifts Generated by Lanthanide Tags at Multiple Sites Structure, Available online 2 May 2013 10 Thomas Zögg | Michael Sponring | Sabrina Schindler | Maria Koll | Rainer Schneider | Hans Brandstetter | Bernhard Auer Crystal Structures of the Viral Protease Npro Imply Distinct Roles for the Catalytic Water in Catalysis Structure, Available online 2 May 2013
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