Form and function in modern biology
Structure aims to publish papers of exceptional interest in the field of structural biology. The journal strives to be essential reading for structural biologists, as well as biologists and biochemists that are interested in macromolecular structure and function. Structure strongly encourages the submission of manuscripts that present structural and molecular insights into biological function and mechanism. Other reports that address fundamental questions in structural biology, such as structure-based examinations of protein evolution, folding and/or design, will also be considered favorably. We will consider the application of any method, experimental or computational, at high or low resolution, to conduct structural investigations, as long as the method is appropriate for the biological, functional, and mechanistic question(s) being addressed. Likewise, reports describing single molecule analysis of biological mechanisms are welcome. In general, the editors encourage submission of structural studies that are validated by additional experimental systems that address structure-activity relationships, and will not consider studies that solely report structural information unless the structure under investigation is of exceptional and broad interest.
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Editors: Christopher D. Lima , Andrej Sali
Impact factor: 5.994Impact factor:
© Thomson Reuters Journal Citation Reports 2013
5 year impact factor: 6.081Five-Year Impact Factor:
To calculate the five year Impact Factor, citations are counted in 2013 to the previous five years and divided by the source items published in the previous five years.
© Journal Citation Reports 2013, Published by Thomson Reuters.
Imprint: Cell Press
Top 10 Cited (articles published in the last five years)
Extracted from Scopus (on Dec 03 )
333 Hanson, M.A. | Cherezov, V. | Griffith, M.T. | Roth, C.B. | Jaakola, V.-P. | Chien, E.Y.T. | Velasquez, J. | Kuhn, P. | Stevens, R.C. A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human ß2-Adrenergic Receptor Structure, Volume 16, Issue 6, 2008-06-11, Pages 897-905 168 Trabuco, L.G. | Villa, E. | Mitra, K. | Frank, J. | Schulten, K. Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics Structure, Volume 16, Issue 5, 2008-05-07, Pages 673-683 131 Mobley, D.L. | Dill, K.A. Binding of Small-Molecule Ligands to Proteins: "What You See" Is Not Always "What You Get" Structure, Volume 17, Issue 4, 2009-04-15, Pages 489-498 129 Cheng, X. | Blumenthal, R.M. Mammalian DNA Methyltransferases: A Structural Perspective Structure, Volume 16, Issue 3, 2008-03-11, Pages 341-350 124 Hanson, M.A. | Stevens, R.C. Discovery of New GPCR Biology: One Receptor Structure at a Time Structure, Volume 17, Issue 1, 2009-01-14, Pages 8-14 118 del Sol, A. | Tsai, C.-J. | Ma, B. | Nussinov, R. The Origin of Allosteric Functional Modulation: Multiple Pre-existing Pathways Structure, Volume 17, Issue 8, 2009-08-12, Pages 1042-1050 111 Möglich, A. | Ayers, R.A. | Moffat, K. Structure and Signaling Mechanism of Per-ARNT-Sim Domains Structure, Volume 17, Issue 10, 2009-10-14, Pages 1282-1294 105 Topf, M. | Lasker, K. | Webb, B. | Wolfson, H. | Chiu, W. | Sali, A. Protein Structure Fitting and Refinement Guided by Cryo-EM Density Structure, Volume 16, Issue 2, 2008-02-12, Pages 295-307 101 Ludtke, S.J. | Baker, M.L. | Chen, D.-H. | Song, J.-L. | Chuang, D.T. | Chiu, W. De Novo Backbone Trace of GroEL from Single Particle Electron Cryomicroscopy Structure, Volume 16, Issue 3, 2008-03-11, Pages 441-448 97 Zlatanova, J. | Thakar, A. H2A.Z: View from the Top Structure, Volume 16, Issue 2, 2008-02-12, Pages 166-179
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Most Read Articles - counted by Article downloads on SciVerse ScienceDirect in the period 01 December 2002 to 30 December 2013
Tue Dec 03
1 Istvan Botos | David M. Segal | David R. Davies The Structural Biology of Toll-like Receptors Structure, Volume 19, Issue 4, 13 April 2011, Pages 447-459 2 Thomas S. Walter | Christoph Meier | Rene Assenberg | Kin-Fai Au | Jingshan Ren | Anil Verma | Joanne E. Nettleship | Raymond J. Owens | David I. Stuart | Jonathan M. Grimes Lysine Methylation as a Routine Rescue Strategy for Protein Crystallization Structure, Volume 14, Issue 11, November 2006, Pages 1617-1622 3 Michael A. Hanson | Vadim Cherezov | Mark T. Griffith | Christopher B. Roth | Veli-Pekka Jaakola | Ellen Y.T. Chien | Jeffrey Velasquez | Peter Kuhn | Raymond C. Stevens A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human ß2-Adrenergic Receptor Structure, Volume 16, Issue 6, 11 June 2008, Pages 897-905 4 Alexander I. Alexandrov | Mauro Mileni | Ellen Y.T. Chien | Michael A. Hanson | Raymond C. Stevens Microscale Fluorescent Thermal Stability Assay for Membrane Proteins Structure, Volume 16, Issue 3, 11 March 2008, Pages 351-359 5 Toshimitsu Kawate | Eric Gouaux Fluorescence-Detection Size-Exclusion Chromatography for Precrystallization Screening of Integral Membrane Proteins Structure, Volume 14, Issue 4, April 2006, Pages 673-681 6 John R Somoza | Robert J Skene | Bradley A Katz | Clifford Mol | Joseph D Ho | Andy J Jennings | Christine Luong | Andrew Arvai | Joseph J Buggy | Ellen Chi | Jie Tang | Bi-Ching Sang | Erik Verner | Robert Wynands | Ellen M Leahy | Douglas R Dougan | Gyorgy Snell | Marc Navre | Mark W Knuth | Ronald V Swanson | Duncan E McRee | Leslie W Tari Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases Structure, Volume 12, Issue 7, July 2004, Pages 1325-1334 7 Graeme L. Card | Bruce P. England | Yoshihisa Suzuki | Daniel Fong | Ben Powell | Byunghun Lee | Catherine Luu | Maryam Tabrizizad | Sam Gillette | Prabha N. Ibrahim | Dean R. Artis | Gideon Bollag | Michael V. Milburn | Sung-Hou Kim | Joseph Schlessinger | Kam Y.J. Zhang Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases Structure, Volume 12, Issue 12, December 2004, Pages 2233-2247 8 Kenji Kamata | Morihiro Mitsuya | Teruyuki Nishimura | Jun-ichi Eiki | Yasufumi Nagata Structural Basis for Allosteric Regulation of the Monomeric Allosteric Enzyme Human Glucokinase Structure, Volume 12, Issue 3, March 2004, Pages 429-438 9 Elena Conti | Nick P Franks | Peter Brick Crystal structure of firefly luciferase throws light on a superfamily of adenylate-forming enzymes Structure, Volume 4, Issue 3, March 1996, Pages 287-298 10 Gideon Davies | Bernard Henrissat Structures and mechanisms of glycosyl hydrolases Structure, Volume 3, Issue 9, September 1995, Pages 853-859
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Tue Dec 03
1 Kelly J. Collins | Zhenyu Yuan | Rhett A. Kovall Structure and Function of the CSL-KyoT2 Corepressor Complex: A Negative Regulator of Notch Signaling Structure, Available online 27 November 2013, 2 Hironori Suzuki | Keisuke Tabata | Eiji Morita | Masato Kawasaki | Ryuichi Kato | Renwick C.J. Dobson | Tamotsu Yoshimori | Soichi Wakatsuki Structural Basis of the Autophagy-Related LC3/Atg13 LIR Complex: Recognition and Interaction Mechanism Structure, Available online 27 November 2013, 3 Suzuka Mikami | Teppei Kanaba | Naoki Takizawa | Ayaho Kobayashi | Ryoko Maesaki | Toshinobu Fujiwara | Yutaka Ito | Masaki Mishima Structural Insights into the Recruitment of SMRT by the Corepressor SHARP under Phosphorylative Regulation Structure, Available online 21 November 2013, 4 Katarzyna Niescierowicz | Lydia Caro | Vadim Cherezov | Michel Vivaudou | Christophe J. Moreau Functional Assay for T4 Lysozyme-Engineered G Protein-Coupled Receptors with an Ion Channel Reporter Structure, Available online 21 November 2013, 5 Hung-Ju Hsu | Kuo Hao Lee | Jhih-Wei Jian | Hung-Ju Chang | Chung-Ming Yu | Yu-Ching Lee | Ing-Chien Chen | Hung-Pin Peng | Chih Yuan Wu | Yu-Feng Huang | Chih-Yun Shao | Kuo Ping Chiu | An-Suei Yang Antibody Variable Domain Interface and Framework Sequence Requirements for Stability and Function by High-Throughput Experiments Structure, Available online 21 November 2013, 6 Hung-Ju Chang | Jhih-Wei Jian | Hung-Ju Hsu | Yu-Ching Lee | Hong-Sen Chen | Jhong-Jhe You | Shin-Chen Hou | Chih-Yun Shao | Yen-Ju Chen | Kuo-Ping Chiu | Hung-Pin Peng | Kuo Hao Lee | An-Suei Yang Loop-Sequence Features and Stability Determinants in Antibody Variable Domains by High-Throughput Experiments Structure, Available online 21 November 2013, 7 Gilbert Y. Huang | Jeong Joo Kim | Albert S. Reger | Robin Lorenz | Eui-Whan Moon | Chi Zhao | Darren E. Casteel | Daniela Bertinetti | Bryan VanSchouwen | Rajeevan Selvaratnam | James W. Pflugrath | Banumathi Sankaran | Giuseppe Melacini | Friedrich W. Herberg | Choel Kim Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I Structure, Available online 14 November 2013, 8 Kerry Fuson | Anne Rice | Ryan Mahling | Adam Snow | Kamakshi Nayak | Prajna Shanbhogue | Austin G. Meyer | Gregory M.I. Redpath | Anne Hinderliter | Sandra T. Cooper | R. Bryan Sutton Alternate Splicing of Dysferlin C2A Confers Ca2+-Dependent and Ca2+-Independent Binding for Membrane Repair Structure, Available online 14 November 2013, 9 Hugo Gutiérrez-de-Terán | Arnault Massink | David Rodríguez | Wei Liu | Gye Won Han | Jeremiah S. Joseph | Ilia Katritch | Laura H. Heitman | Lizi Xia | Adriaan P. IJzerman | Vadim Cherezov | Vsevolod Katritch | Raymond C. Stevens The Role of a Sodium Ion Binding Site in the Allosteric Modulation of the A2A Adenosine G Protein-Coupled Receptor Structure, Available online 7 November 2013, 10 Jeanine F. Amacher | Patrick R. Cushing | Lionel Brooks 3rd | Prisca Boisguerin | Dean R. Madden Stereochemical Preferences Modulate Affinity and Selectivity among Five PDZ Domains that Bind CFTR: Comparative Structural and Sequence Analyses Structure, Available online 7 November 2013,
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