Guide for Authors

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    INTRODUCTION
    • Types of paper
    BEFORE YOU BEGIN
    • Ethics in Publishing
    • Conflict of interest
    • Submission declaration and verification
    • Authorship
    • Changes to authorship
    • Article transfer service
    • Copyright
    • Role of the funding source
    • Open access
    • Language (usage and editing services)
    • Submission
    • Referees
    PREPARATION
    • Use of word processing software
    • Article structure
    • Essential title page information
    • Abstract
    • Graphical abstract
    • Highlights
    • Abbreviations
    • Database linking
    • Footnotes
    • Artwork
    • Color artwork
    • Figure captions
    • References
    • Citation in text
    • AudioSlides
    • Submission checklist
    AFTER ACCEPTANCE
    • Use of the Digital Object Identifier
    • Online proof correction
    • Offprints
    AUTHOR INQUIRIES

    Types of paper

    Significant original research papers and pertinent reviews on all aspects of steroids will be considered for publication. Specifically, both experimental and theoretical studies dealing with the following areas of investigation are welcome: chemistry and physiochemistry; biosynthesis; metabolism; molecular biology; physiology; pharmacology; analytical techniques; comparative endocrinology; clinical research; mode of action (including that of related peptides); and the role of steroids on growth and differentiation. Relevant compounds also include non-steroidal analogs that are inhibitors or activators of steroid biosynthetic enzymes or ligands for steroid hormone receptors

    Letters to the editor are welcome, for editing and publication at the discretion of the editor. Rapid Communications will be considered if material is of unusual interest and particularly timely.

    Publication of Articles Describing the Isolation and Identification of New Steroids or the Synthesis of New Steroids or Steroid Derivatives

    Articles reporting solely the isolation and identification of previously unknown steroids are not necessarily suitable for publication in Steroids. Among the considerations used by editors and reviewers in evaluating the significance of such manuscripts are the types of structural variations compared to known steroids, the isolation source, and the experimental methods used in structure determination. Similarly, for articles describing only the synthesis of new steroids or steroid derivatives, important considerations will be the novelty of the approach or reactions used for the preparation, and the structural novelty of the new synthetic products. With both isolated and newly synthesized compounds, additional consideration will be given to their biochemical and/or biological activities as well as the potential utility of the structural characterization and bioactivity data to other researchers. Authors should comment upon these matters in the Highlights, Abstract, Introduction, and/or Conclusions. All articles will be evaluated for appropriate English language usage, and the quality of the figures.

    Ethics in Publishing

    For information on Ethics in Publishing and Ethical guidelines for journal publication see http://www.elsevier.com/publishingethics and http://www.elsevier.com/ethicalguidelines.

    When experimental animals are used, the materials and methods section must clearly indicate that adequate measures were taken to minimize pain or discomfort, and that the experiments were conducted in accordance with international standards on animal welfare as well as being compliant with local and national regulations. Studies are expected to be compliant with minimal standards as defined by the European Communities Council Directive of 24 November 1986 (86/609/EEC) http://europa.eu.int/comm/food/fs/aw/aw_legislation/scientific/86-609-eec_en.PDF and the National Institutes of Health Guide for the Care and Use of Laboratory Animals http://www.nap.edu/readingroom/books/labrats/ Full details of any anesthetic or analgesic dose and treatment must be given.

    Conflict of interest

    All authors are requested to disclose any actual or potential conflict of interest including any financial, personal or other relationships with other people or organizations within three years of beginning the submitted work that could inappropriately influence, or be perceived to influence, their work. See also http://www.elsevier.com/conflictsofinterest. Further information and an example of a Conflict of Interest form can be found at: http://help.elsevier.com/app/answers/detail/a_id/286/p/7923.

    Submission declaration and verification

    Submission of an article implies that the work described has not been published previously (except in the form of an abstract or as part of a published lecture or academic thesis or as an electronic preprint, see http://www.elsevier.com/postingpolicy), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, including electronically without the written consent of the copyright-holder. To verify originality, your article may be checked by the originality detection service CrossCheck http://www.elsevier.com/editors/plagdetect.

    Authorship

    All authors should have made substantial contributions to all of the following: (1) the conception and design of the study, or acquisition of data, or analysis and interpretation of data, (2) drafting the article or revising it critically for important intellectual content, (3) final approval of the version to be submitted.

    Changes to authorship

    This policy concerns the addition, deletion, or rearrangement of author names in the authorship of accepted manuscripts:
    Before the accepted manuscript is published in an online issue: Requests to add or remove an author, or to rearrange the author names, must be sent to the Journal Manager from the corresponding author of the accepted manuscript and must include: (a) the reason the name should be added or removed, or the author names rearranged and (b) written confirmation (e-mail, fax, letter) from all authors that they agree with the addition, removal or rearrangement. In the case of addition or removal of authors, this includes confirmation from the author being added or removed. Requests that are not sent by the corresponding author will be forwarded by the Journal Manager to the corresponding author, who must follow the procedure as described above. Note that: (1) Journal Managers will inform the Journal Editors of any such requests and (2) publication of the accepted manuscript in an online issue is suspended until authorship has been agreed.
    After the accepted manuscript is published in an online issue: Any requests to add, delete, or rearrange author names in an article published in an online issue will follow the same policies as noted above and result in a corrigendum.

    Article transfer service

    This journal is part of our Article Transfer Service. This means that if the Editor feels your article is more suitable in one of our other participating journals, then you may be asked to consider transferring the article to one of those. If you agree, your article will be transferred automatically on your behalf with no need to reformat. More information about this can be found here: http://www.elsevier.com/authors/article-transfer-service.

    Copyright

    This journal offers authors a choice in publishing their research: Open Access and Subscription.

    For Subscription articles
    Upon acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement' (for more information on this and copyright, see http://www.elsevier.com/copyright). An e-mail will be sent to the corresponding author confirming receipt of the manuscript together with a 'Journal Publishing Agreement' form or a link to the online version of this agreement.
    Subscribers may reproduce tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution outside the institution and for all other derivative works, including compilations and translations (please consult http://www.elsevier.com/permissions). If excerpts from other copyrighted works are included, the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases: please consult http://www.elsevier.com/permissions.

    For Open Access articles
    Upon acceptance of an article, authors will be asked to complete an 'Exclusive License Agreement' (for more information see http://www.elsevier.com/OAauthoragreement). Permitted reuse of open access articles is determined by the author's choice of user license (see http://www.elsevier.com/openaccesslicenses).

    Retained author rights

    As an author you (or your employer or institution) retain certain rights. For more information on author rights for:
    Subscription articles please see http://www.elsevier.com/authorsrights.
    Open access articles please see http://www.elsevier.com/OAauthoragreement.

    Upon acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement' (for more information on this and copyright see http://www.elsevier.com/copyright). An e-mail will be sent to the corresponding author confirming receipt of the manuscript together with a 'Journal Publishing Agreement' form or a link to the online version of this agreement.
    Subscribers may reproduce tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution outside the institution and for all other derivative works, including compilations and translations (please consult http://www.elsevier.com/permissions). If excerpts from other copyrighted works are included, the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases: please consult http://www.elsevier.com/permissions.

    Role of the funding source

    You are requested to identify who provided financial support for the conduct of the research and/or preparation of the article and to briefly describe the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. If the funding source(s) had no such involvement then this should be stated.

    Funding body agreements and policies
    Elsevier has established agreements and developed policies to allow authors whose articles appear in journals published by Elsevier, to comply with potential manuscript archiving requirements as specified as conditions of their grant awards. To learn more about existing agreements and policies please visit http://www.elsevier.com/fundingbodies.

    US National Institutes of Health (NIH) voluntary posting (" Public Access") policy.

    As a service to our authors, Elsevier will deposit to PubMed Central (PMC) author manuscripts on behalf of Elsevier authors reporting NIH funded research. This service is a continuation of Elsevier's 2005 agreement with the NIH when the NIH introduced their voluntary 'Public Access Policy.'

    The service will help authors comply with the National Institutes of Health (NIH) revised ''Public Access Policy,'' effective April 7, 2008. The NIH's revised policy requires that NIH-funded authors submit to PubMed Central (PMC), or have submitted on their behalf, their peer-reviewed author manuscripts, to appear on PMC no later than 12 months after final publication.

    Elsevier will send to PMC the final peer-reviewed manuscript, which was accepted for publication and sent to Elsevier's production department, and that reflects any author-agreed changes made in response to peer-review comments. Elsevier will authorize the author manuscript's public access posting 12 months after final publication. Following the deposit by Elsevier, authors will receive further communications from Elsevier and NIH with respect to the submission.

    Authors are also welcome to post their accepted author manuscript on their personal or institutional web site. Please note that consistent with Elsevier's author agreement, authors should not post manuscripts directly to PMC or other third party sites. Individual modifications to this general policy may apply to some Elsevier journals and society publishing partners.

    As a leading publisher of scientific, technical and medical (STM) journals, Elsevier has led the industry in developing tools, programs and partnerships that provide greater access to, and understanding of, the vast global body of STM information. This service is an example of Elsevier willingness to work cooperatively to meet the needs of all participants in the STM publishing community. Open access

    This journal offers authors a choice in publishing their research:

    Open access
    • Articles are freely available to both subscribers and the wider public with permitted reuse
    • An open access publication fee is payable by authors or their research funder
    Subscription
    • Articles are made available to subscribers as well as developing countries and patient groups through our access programs (http://www.elsevier.com/access)
    • No open access publication fee

    All articles published open access will be immediately and permanently free for everyone to read and download. Permitted reuse is defined by your choice of one of the following Creative Commons user licenses:
    Creative Commons Attribution (CC BY): lets others distribute and copy the article, to create extracts, abstracts, and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text or data mine the article, even for commercial purposes, as long as they credit the author(s), do not represent the author as endorsing their adaptation of the article, and do not modify the article in such a way as to damage the author's honor or reputation.
    Creative Commons Attribution-NonCommercial-ShareAlike (CC BY-NC-SA): for non-commercial purposes, lets others distribute and copy the article, to create extracts, abstracts and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text and data mine the article, as long as they credit the author(s), do not represent the author as endorsing their adaptation of the article, do not modify the article in such a way as to damage the author's honor or reputation, and license their new adaptations or creations under identical terms (CC BY-NC-SA).
    Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND): for non-commercial purposes, lets others distribute and copy the article, and to include in a collective work (such as an anthology), as long as they credit the author(s) and provided they do not alter or modify the article.

    To provide open access, this journal has a publication fee which needs to be met by the authors or their research funders for each article published open access.
    Your publication choice will have no effect on the peer review process or acceptance of submitted articles.

    The publication fee for Open Access in this journal is $3,000, excluding taxes. Learn more about Elsevier's pricing policy: http://www.elsevier.com/openaccesspricing.

    Language (usage and editing services)

    Please write your text in good English (American or British usage is accepted, but not a mixture of these). Authors who feel their English language manuscript may require editing to eliminate possible grammatical or spelling errors and to conform to correct scientific English may wish to use the English Language Editing service available from Elsevier's WebShop (http://webshop.elsevier.com/languageediting/) or visit our customer support site (http://support.elsevier.com) for more information.

    Submission

    Submission to this journal proceeds totally online. Visit the submission site of the journal at http://ees.elsevier.com/steroids You will be guided through the creation and uploading of your files. The system automatically converts source files to a single PDF file of the article, which is used in the peer-review process. Please note that even though manuscript source files are converted to PDF files at submission for the review process, these source files are needed for further processing after acceptance. All correspondence, including notification of the Editor's decision and requests for revision, takes place by e-mail.

    Referees

    Please submit, with the manuscript, the names, addresses and e-mail addresses of 4 potential referees. Note that the editor retains the sole right to decide whether or not the suggested reviewers are used.

    Use of word processing software

    It is important that the file be saved in the native format of the word processor used. The text should be in single-column format. Keep the layout of the text as simple as possible. Most formatting codes will be removed and replaced on processing the article. In particular, do not use the word processor's options to justify text or to hyphenate words. However, do use bold face, italics, subscripts, superscripts etc. When preparing tables, if you are using a table grid, use only one grid for each individual table and not a grid for each row. If no grid is used, use tabs, not spaces, to align columns. The electronic text should be prepared in a way very similar to that of conventional manuscripts (see also the Guide to Publishing with Elsevier: http://www.elsevier.com/guidepublication). Note that source files of figures, tables and text graphics will be required whether or not you embed your figures in the text. See also the section on Electronic artwork.
    To avoid unnecessary errors you are strongly advised to use the 'spell-check' and 'grammar-check' functions of your word processor.

    Article structure

    Manuscripts Arrange the manuscript in the following order: title page, abstract, keywords, text, acknowledgments, references, footnotes, tables, figure legends, and figures. Number the pages in sequence, with the title page as page 1, the abstract as page 2, etc. Text: Arrange the body of the manuscript in the following order:
    Introduction, Experimental, Results, Discussion.
    Title page

    Give the full title of paper. Do not use asterisks or other extraneous symbols in the title. Give the first name, middle initial, and last name of all authors. List each author's institutional affiliation(s). Show the address of each author at the time of the study as well as the present address if it differs.

    Provide the name and address of the corresponding author to whom questions and reprint requests should be sent. Give the name and address of the institution from which the work originated.

    Text
    Arrange the text in the following order:

    • Introduction: The rationale for the study. Provide a brief account of the nature, approach and importance of the study to be presented.
    • Experimental: A clear and precise description of the experimental procedures. Identify all drugs and chemicals used, dosages, and routes of administration. All methods must be referenced and/or described in sufficient detail to enable a reader to repeat the experiment. For animal and human studies, the experimental protocol must be humane and ethical. In all manuscripts reporting the results of human studies, a statement must appear in the Experimental section indicating that approval was obtained from the institutional review board and that all human subjects signed written informed consent.
    • Results: A factual account of the study's findings. Present these as logically appropriate in text, tables, or figures; do not repeat in the text what is demonstrated in a table or figure.
    • Discussion: Place the results of the study in present and historical context and denote its importance to the field. Ensure that all conclusions are justified by the results of the study.

    Appendices
    If there is more than one appendix, they should be identified as A, B, etc. Formulae and equations in appendices should be given separate numbering: Eq. (A.1), Eq. (A.2), etc.; in a subsequent appendix, Eq. (B.1) and so on. Similarly for tables and figures: Table A.1; Fig. A.1, etc.

    Essential title page information

    Title. Concise and informative. Titles are often used in information-retrieval systems. Avoid abbreviations and formulae where possible.
    Author names and affiliations. Where the family name may be ambiguous (e.g., a double name), please indicate this clearly. Present the authors' affiliation addresses (where the actual work was done) below the names. Indicate all affiliations with a lower-case superscript letter immediately after the author's name and in front of the appropriate address. Provide the full postal address of each affiliation, including the country name and, if available, the e-mail address of each author.
    Corresponding author. Clearly indicate who will handle correspondence at all stages of refereeing and publication, also post-publication. Ensure that phone numbers (with country and area code) are provided in addition to the e-mail address and the complete postal address. Contact details must be kept up to date by the corresponding author.
    Present/permanent address. If an author has moved since the work described in the article was done, or was visiting at the time, a 'Present address' (or 'Permanent address') may be indicated as a footnote to that author's name. The address at which the author actually did the work must be retained as the main, affiliation address. Superscript Arabic numerals are used for such footnotes.

    Abstract

    A concise and factual abstract is required (maximum length 250 words). The abstract should state briefly the purpose of the research, the principal results, and major conclusions. An abstract is often presented separately from the article, so it must be able to stand alone. References should be avoided but, if essential, they must be cited in full. Avoid non-standard or uncommon abbreviations; if they must be used, define them at their first mention in the abstract itself.

    Graphical abstract

    A Graphical abstract is optional and should summarize the contents of the article in a concise, pictorial form designed to capture the attention of a wide readership online. Authors must provide images that clearly represent the work described in the article. Graphical abstracts should be submitted as a separate file in the online submission system. Image size: Please provide an image with a minimum of 531 × 1328 pixels (h × w) or proportionally more. The image should be readable at a size of 5 × 13 cm using a regular screen resolution of 96 dpi. Preferred file types: TIFF, EPS, PDF or MS Office files. See http://www.elsevier.com/graphicalabstracts for examples.
    Authors can make use of Elsevier's Illustration and Enhancement service to ensure the best presentation of their images also in accordance with all technical requirements: Illustration Service.

    Highlights

    Highlights are mandatory for this journal. They consist of a short collection of bullet points that convey the core findings of the article and should be submitted in a separate file in the online submission system. Please use 'Highlights' in the file name and include 3 to 5 bullet points (maximum 85 characters, including spaces, per bullet point). See http://www.elsevier.com/highlights for examples.

    Keywords
    Immediately after the abstract, provide a maximum of six keywords, avoiding general and plural terms and multiple concepts (avoid, for example, "and", "of"). Be sparing with abbreviations; only firmly established ones should be used.

    Abbreviations

    Define abbreviations that are not standard in this field in a footnote to be placed on the first page of the article. Such abbreviations that are unavoidable in the abstract must be defined at their first mention there, as well as in the footnote. Ensure consistency of abbreviations throughout the article.

    Acknowledgements
    Acknowledge grants, sponsors, funding sources, and individuals who provided significant assistance. Include the affiliations of individuals being thanked. It is the author's responsibility to obtain permission from all those mentioned by name, because readers may infer their endorsement.

    Units of measure
    Standard metric units are preferred. SI units are optional, except that the use of Bq (becquerel) is not acceptable; use Ci (curie) or dpm (disintegrations per minute). Centrifugation should be described in terms of force (_g), not as rpm.

    Nomenclature and units
    Refer to drugs by their approved generic names. If trade names are used, the generic equivalent should be given parenthetically at the first use. Identify compounds by their formal chemical name at first use; thereafter the trivial name may be used. All names should be in accordance with the most recent IUPAC-IUB rules on the nomenclature of steroids published in Pure and Applied Chemistry 61, 1783-1822, 1989. Substituted steroids should be named so that only one functional group is designated as a suffix and all other substituents are listed as X steroids 71 (2006) IX-XI prefixes. If the first letter of the suffix is a vowel, the terminal 'e' of the name of the hydrocarbon should be dropped (e.g., etiocholan-17-one). Unsaturation should be indicated by writing the locant number for the double bond(s) before the suffix (e.g., 3-hydroxyandrost-5-en-17-one). Trivial names may be modified by prefixes indicating substituents (e.g., 17-hydroxyprogesterone) but must not be more cumbersome than the systematic names they replace. Chemically impossible trivial names (e.g., 20-hydroxyprogesterone) are not acceptable. Alcohols are named as ols or hydroxy derivatives, not as dihydroketones. Isotope location should be designated by a prefix bracket placed directly before the part of the name to which it applies (i.e., without a space or hyphen): e.g., 3,20-dihydroxy-[4-14C]pregnan-7-one; [3-3H]methoxyandrostan-17-one, 11?,21-dihydroxy-[1,2-3H; 4-14C]pregnane-3,20-dione. Iodinated compounds, in which iodine is part of the structure, are to be labeled in the same manner; e.g., [16?-125I]iodoestradiol; 3-hydroxy-[21-125I]iodopregn-5-en-20-one.

    Follow internationally accepted rules and conventions: use the international system of units (SI). If other quantities are mentioned, give their equivalent in SI. You are urged to consult IUPAC: Nomenclature of Organic Chemistry:http://www.iupac.org/publications/pac/1989/pdf/6110x1783.pdf for further information.

    Guidelines Concerning Identification, Characterization, and Purity of Compounds
    Compound identity and purity

    Evidence must be presented establishing the identity and purity of all new compounds, and of all compounds subjected to biochemical or biological assays. High quality reproductions of 1H and 13C NMR spectra must accompany the manuscript, in a Supporting Information Section, which will not appear in the journal, but will used by reviewers and be available on the web (see below). A structure drawing and structure number should be placed on each NMR spectrum, along with the solvent and field strength. The contents of the Supporting Information Section should be summarized in a brief statement at the end of the manuscript, and a complete Table of Contents should appear at the beginning of the Supporting Information Section. When single-crystal X-ray diffraction structures are reported, CIF files need to be furnished as separate supporting information files, even if text tables of crystallographic data are included, and even if the data have been deposited in a crystallographic database.

    Identification of structure: Sufficient spectroscopic information must be presented to establish the structural identity of all new compounds, whether isolated as naturally occurring steroids or newly synthesized ones. These data should appear in the Experimental Section and be adequate for unambiguous structure elucidation. A list of proton or 1H and 13C NMR peaks is generally sufficient, but if structural identification was based on NMR data, peak assignments should also be given. Chemical shift data should be given only to two decimal places. Infrared absorptions, diagnostic for key functional groups, are also helpful, and high resolution mass spectroscopic data can provide an additional criterion of compound identity. When a series of closely related compounds is reported, spectroscopic data can be presented in a table, or full spectroscopic data for a representative member can be presented, with comments made on the spectral features unique to other members of the series. For known compounds, the source or literature reference(s) to the previous isolation or to the previous method of preparation and characterization must be provided.

    For known compounds, indicate the observed and literature melting points for crystalline solids, and/or the observed and literature optical rotations, in the following formats: mp xx oC (lit [ref] xx oC) and/or [α]DºC ± xxo (c, xx g/100 mL; solvent) (lit [ref] [α]D ºC ± xxo (c, xx g/100 mL; solvent). Provide comments (either in general or for individual compounds) comparing the observed 1H and 13C NMR data of known compounds with the literature values, e.g., “The 1H and 13C NMR data (xx MHz, solvent) agreed well with the literature values [ref].” It is not necessary to report complete data sets for known compounds. However, significantly different or improved data (e.g., different chemical shifts, data in different solvents, data taken at higher field, improved coupling analyses, etc.) should be reported in the Experimental Section or in a Table of NMR data and assignments.

    Many naturally occurring steroids are isolated as glycoside derivatives. In such cases, the structures and absolute configuration of the individual sugar residues should be determined after hydrolysis. The absolute configuration of an individual sugar can be determined by comparing its optical rotation with the literature value for sugars of well-established absolute configuration. Another approach is direct comparison with authentic samples of the D and L sugars, or their derivatives, by high-pressure liquid chromatography (HPLC) or by gas chromatography (GC) on columns containing suitable chiral adsorbents, provided it is demonstrated that the enantiomeric compounds give separate peaks on the chiral columns.

    Criteria for the purity of all compounds and of compounds with biological data: All new compounds need to be pure. Evidence of high purity is essential where biochemical or biological assay data are presented and related to compound structures; these compounds are termed "SAR compounds." The purity of SAR compounds should be more than 98 percent; the purity of other compounds should be more than 95 percent. Any questions regarding the purity of SAR compounds should appear in the Results.
    The methods used to establish the purity of steroids subjected to biochemical or biological assays must be described in the Experimental Section. Most steroids obtained in pure form will be crystalline. Thus, there should be an attempt to purify and crystallize all products of chemical reactions or compounds isolated from plant extracts. Melting points should be recorded and reported for all crystalline compounds. It is strongly recommended that optical rotations be reported for new compounds. The weights and % yields should be reported for products isolated from chemical transformations.

    Evidence for purity can take many forms: Combustion analyses for carbon, hydrogen and nitrogen are adequate. These data should appear in the Experimental Section and should agree with the calculated data within 0.4 percent. A recommended form for presentation is: C18H23NO4: calcd. C, 68.12; H, 7.30; N, 4.41. Found. C, 68.50; H, 7.18; N, 4.26. When satisfactory combustion analyses are not available, evidence of purity should be provided by HPLC chromatograms run in two divergent solvent systems (typically normal and reversed phase) or by high quality proton NMR spectra obtained at high signal-to-noise. These chromatograms or spectra should be included as supplementary data.

    Database linking

    Elsevier encourages authors to connect articles with external databases, giving their readers one-click access to relevant databases that help to build a better understanding of the described research. Please refer to relevant database identifiers using the following format in your article: Database: xxxx (e.g., TAIR: AT1G01020; CCDC: 734053; PDB: 1XFN). See http://www.elsevier.com/databaselinking for more information and a full list of supported databases.

    Footnotes

    Footnotes should be used sparingly. Number them consecutively throughout the article, using superscript Arabic numbers. Many wordprocessors build footnotes into the text, and this feature may be used. Should this not be the case, indicate the position of footnotes in the text and present the footnotes themselves separately at the end of the article. Do not include footnotes in the Reference list.
    Table footnotes
    Indicate each footnote in a table with a superscript lowercase letter.

    Artwork

    Electronic artwork
    General points
    • Make sure you use uniform lettering and sizing of your original artwork.
    • Embed the used fonts if the application provides that option.
    • Aim to use the following fonts in your illustrations: Arial, Courier, Times New Roman, Symbol, or use fonts that look similar.
    • Number the illustrations according to their sequence in the text.
    • Use a logical naming convention for your artwork files.
    • Provide captions to illustrations separately.
    • Size the illustrations close to the desired dimensions of the printed version.
    • Submit each illustration as a separate file.
    A detailed guide on electronic artwork is available on our website:
    http://www.elsevier.com/artworkinstructions
    You are urged to visit this site; some excerpts from the detailed information are given here.
    Formats
    If your electronic artwork is created in a Microsoft Office application (Word, PowerPoint, Excel) then please supply 'as is' in the native document format.
    Regardless of the application used other than Microsoft Office, when your electronic artwork is finalized, please 'Save as' or convert the images to one of the following formats (note the resolution requirements for line drawings, halftones, and line/halftone combinations given below):
    EPS (or PDF): Vector drawings, embed all used fonts.
    TIFF (or JPEG): Color or grayscale photographs (halftones), keep to a minimum of 300 dpi.
    TIFF (or JPEG): Bitmapped (pure black & white pixels) line drawings, keep to a minimum of 1000 dpi.
    TIFF (or JPEG): Combinations bitmapped line/half-tone (color or grayscale), keep to a minimum of 500 dpi.
    Please do not:
    • Supply files that are optimized for screen use (e.g., GIF, BMP, PICT, WPG); these typically have a low number of pixels and limited set of colors;
    • Supply files that are too low in resolution;
    • Submit graphics that are disproportionately large for the content.

    Color artwork

    Figures
    Please make sure that artwork files are in an acceptable format (TIFF, EPS, or MS Office files) and with good resolution, please see http://www.elsevier.com/artworkinstructions.

    Colour figures
    If together with your accepted article, you submit usable colour figures, then Elsevier will ensure, at no additional charge, that these figures will appear in colour on the Web (e.g., ScienceDirect and other sites) regardless of whether these illustrations are reproduced in colour in the printed version. For colour reproduction in print, you will receive information regarding the costs from Elsevier after receipt of your accepted article. For further information on the preparation of electronic artwork, please see http://www.elsevier.com/artworkinstructions [Please note: Because of technical complications that can arise in converting colour figures to "grey scale" (for the printed version should you not opt for colour in print), please submit in addition usable black-and-white files corresponding to all the colour illustrations].

    Figure captions

    Figure legends
    Provide a concise legend for each figure that is sufficiently clear so that the figure can be understood without reference to the text. Legends to figures should be presented on a separate page. Identify and explain all abbreviations, symbols, and figure parts. The use of symbols in legends is restricted to standard ones that can be typeset; it is usually preferable to place the key symbols directly on the art.

    Tables
    Provide a title for each table. If a table must be continued to a second page, repeat all headings.

    References

    Citation in text

    Please ensure that every reference cited in the text is also present in the reference list (and vice versa). Any references cited in the abstract must be given in full in the abstract itself. Unpublished results and personal communications are not recommended in the reference list, but may be mentioned in the text. If these references are included in the reference list they should follow the standard reference style of the journal and should include a substitution of the publication date with either "Unpublished results" or "Personal communication" Citation of a reference as "in press" implies that the item has been accepted for publication.

    Reference links
    Increased discoverability of research and high quality peer review are ensured by online links to the sources cited. In order to allow us to create links to abstracting and indexing services, such as Scopus, CrossRef and PubMed, please ensure that data provided in the references are correct. Please note that incorrect surnames, journal/book titles, publication year and pagination may prevent link creation. When copying references, please be careful as they may already contain errors. Use of the DOI is encouraged.

    Web references
    As a minimum, the full URL should be given and the date when the reference was last accessed. Any further information, if known (DOI, author names, dates, reference to a source publication, etc.), should also be given. Web references can be listed separately (e.g., after the reference list) under a different heading if desired, or can be included in the reference list.

    References in a special issue
    Please ensure that the words 'this issue' are added to any references in the list (and any citations in the text) to other articles in the same Special Issue.

    Reference formatting
    There are no strict requirements on reference formatting at submission. References can be in any style or format as long as the style is consistent. Where applicable, author(s) name(s), journal title/book title, chapter title/article title, year of publication, volume number/book chapter and the pagination must be present. Use of DOI is highly encouraged. The reference style used by the journal will be applied to the accepted article by Elsevier at the proof stage. Note that missing data will be highlighted at proof stage for the author to correct. If you do wish to format the references yourself they should be arranged according to the following examples:

    Reference style
    Text: Indicate references by number(s) in square brackets in line with the text. The actual authors can be referred to, but the reference number(s) must always be given.
    List: Number the references (numbers in square brackets) in the list in the order in which they appear in the text.
    Examples:
    Reference to a journal publication:
    [1] Van der Geer J, Hanraads JAJ, Lupton RA. The art of writing a scientific article. J Sci Commun 2010;163:51–9.
    Reference to a book:
    [2] Strunk Jr W, White EB. The elements of style. 4th ed. New York: Longman; 2000.
    Reference to a chapter in an edited book:
    [3] Mettam GR, Adams LB. How to prepare an electronic version of your article. In: Jones BS, Smith RZ, editors. Introduction to the electronic age, New York: E-Publishing Inc; 2009, p. 281–304.
    Note shortened form for last page number. e.g., 51–9, and that for more than 6 authors the first 6 should be listed followed by 'et al.' For further details you are referred to 'Uniform Requirements for Manuscripts submitted to Biomedical Journals' (J Am Med Assoc 1997;277:927–34) (see also http://www.nlm.nih.gov/bsd/uniform_requirements.html).

    Journal abbreviations source
    Journal names should be abbreviated according to the List of Title Word Abbreviations: http://www.issn.org/services/online-services/access-to-the-ltwa/.

    Video data
    Elsevier accepts video material and animation sequences to support and enhance your scientific research. Authors who have video or animation files that they wish to submit with their article are strongly encouraged to include these within the body of the article. This can be done in the same way as a figure or table by referring to the video or animation content and noting in the body text where it should be placed. All submitted files should be properly labeled so that they directly relate to the video file's content. To ensure that your video or animation material is directly usable, please provide the files in one of our recommended file formats with a maximum size of 30 MB and running time of 5 minutes. Video and animation files will be published online in the electronic version of your article in Elsevier Web products, including ScienceDirect: http://www.sciencedirect.com. Please supply 'stills' with your files: you can choose any frame from the video or animation or make a separate image. These will be used instead of standard icons and will personalize the link to your video data. For more detailed instructions please visit our video instruction pages at http://www.elsevier.com/artworkinstructions. Note: since video and animation cannot be embedded in the print version of the journal, please provide text for both the electronic and the print version for the portions of the article that refer to this content.

    AudioSlides

    The journal encourages authors to create an AudioSlides presentation with their published article. AudioSlides are brief, webinar-style presentations that are shown next to the online article on ScienceDirect. This gives authors the opportunity to summarize their research in their own words and to help readers understand what the paper is about. More information and examples are available at http://www.elsevier.com/audioslides. Authors of this journal will automatically receive an invitation e-mail to create an AudioSlides presentation after acceptance of their paper.

    Supplementary data
    Preparation of supplementary data
    Elsevier accepts supplementary material to support and enhance your scientific research. Supplementary files offer the author additional possibilities to publish supporting applications, movies, animation sequences, high-resolution images, background datasets, sound clips and more. Supplementary files supplied will be published online alongside the electronic version of your article in Elsevier Web products, including ScienceDirect: http://www.sciencedirect.com. To ensure that your submitted material is directly usable, please ensure that data is provided in one of our recommended file formats: TIFF, EPS or PDF. MS Office files (Word, Powerpoint, Excel). Authors should submit the material in electronic format together with the article and supply a concise and descriptive caption for each file. For more detailed instructions please visit our artwork instruction pages at http://www.elsevier.com/artworkinstructions."

    Submission checklist

    The following list will be useful during the final checking of an article prior to sending it to the journal for review. Please consult this Guide for Authors for further details of any item.
    Ensure that the following items are present:
    One author has been designated as the corresponding author with contact details:
    • E-mail address
    • Full postal address
    • Phone numbers
    All necessary files have been uploaded, and contain:
    • Keywords
    • All figure captions
    • All tables (including title, description, footnotes)
    Further considerations
    • Manuscript has been 'spell-checked' and 'grammar-checked'
    • References are in the correct format for this journal
    • All references mentioned in the Reference list are cited in the text, and vice versa
    • Permission has been obtained for use of copyrighted material from other sources (including the Web)
    • Color figures are clearly marked as being intended for color reproduction on the Web (free of charge) and in print, or to be reproduced in color on the Web (free of charge) and in black-and-white in print
    • If only color on the Web is required, black-and-white versions of the figures are also supplied for printing purposes
    For any further information please visit our customer support site at http://support.elsevier.com.

    DNA sequences and GenBank Accession numbers

    Many journals cite ''gene accession numbers'' in their running text and footnotes. Gene accession numbers refer to genes or DNA sequences about which further information can be found in the databases at the National Center for Biotechnical Information (NCBI) at the National Library of Medicine. Authors wishing to enable other scientists to use the accession numbers cited in their papers via links to these sources should type this information in the following manner: For each and every accession number cited in an article, authors should type the accession number in bold, underlined text. Letters in the accession number should always be capitalized. (See Example 1 below). This combination of letters and format will enable Elsevier's typesetters to recognize the relevant texts as accession numbers and add the required link to GenBank's sequences.

    Example 1: ''(GenBank accession nos. AI631510, AI631511,AI632198, and BF223228), a B-cell tumor from a chronic lymphatic leukemia (GenBank accession no. BE675048), and a T cell lymphoma (GenBank accession no. AA361117)''. Authors are encouraged to check accession numbers used very carefully. An error in a letter or number can result in a dead link. In the final version of the printed article, the accession number text will not appear bold or underlined (see Example 2 below).

    Example 2: ''(GenBank accession nos. AI631510, AI631511, AI632198, and BF223228), a B-cell tumor from a chronic lymphatic leukemia (GenBank accession no. BE675048), and a T-cell lymphoma (GenBank accession no. AA361117)''. In the final version of the electronic copy, the accession number text will be linked to the appropriate source in the NCBI databases, enabling readers to go directly to that source from the article (see Example 3 below).

    Example 3: ''(GenBank accession nos. AI631510, AI631511, AI632198, and BF223228), a B-cell tumor from a chronic lymphatic leukemia (GenBank accession no. BE675048), and a T-cell lymphoma (GenBank accession no. AA361117)''.

    Style
    Note that Steroids uses the serial comma, e.g., Jones, Smith, and Brown (comma before 'and' in a series of three or more items). American-style spelling is required. For example: color, not colour; hydrolyze, not hydrolyse; estrogen, not oestrogen; labeled, not labelled. End-of-line hyphenation should be according to American-style word division (based on pronunciation, not word derivation). Leave a space between number and unit (50 mg, 3.5 M). For solvent proportions use the following style: ethanol/methanol (70:30 v/v) or ethyl acetate/isooctane (1:1).

    Letters to the Editor
    There is no specific format but there should be a short abstract of no more than 2 sentences; and no more than 5 references. There is word limit of 2, 500 words, not to exceed 2 -3 published pages including figures , tables, abstract and references. A maximum of any combination of 2 tables or figures is allowed.

    Use of the Digital Object Identifier

    The Digital Object Identifier (DOI) may be used to cite and link to electronic documents. The DOI consists of a unique alpha-numeric character string which is assigned to a document by the publisher upon the initial electronic publication. The assigned DOI never changes. Therefore, it is an ideal medium for citing a document, particularly 'Articles in press' because they have not yet received their full bibliographic information. Example of a correctly given DOI (in URL format; here an article in the journal Physics Letters B):
    http://dx.doi.org/10.1016/j.physletb.2010.09.059
    When you use a DOI to create links to documents on the web, the DOIs are guaranteed never to change.

    Online proof correction

    Corresponding authors will receive an e-mail with a link to our online proofing system, allowing annotation and correction of proofs online. The environment is similar to MS Word: in addition to editing text, you can also comment on figures/tables and answer questions from the Copy Editor. Web-based proofing provides a faster and less error-prone process by allowing you to directly type your corrections, eliminating the potential introduction of errors.
    If preferred, you can still choose to annotate and upload your edits on the PDF version. All instructions for proofing will be given in the e-mail we send to authors, including alternative methods to the online version and PDF.
    We will do everything possible to get your article published quickly and accurately - please upload all of your corrections within 48 hours. It is important to ensure that all corrections are sent back to us in one communication. Please check carefully before replying, as inclusion of any subsequent corrections cannot be guaranteed. Proofreading is solely your responsibility. Note that Elsevier may proceed with the publication of your article if no response is received.

    Offprints

    The corresponding author, at no cost, will be provided with a personalized link providing 50 days free access to the final published version of the article on ScienceDirect. This link can also be used for sharing via email and social networks. For an extra charge, paper offprints can be ordered via the offprint order form which is sent once the article is accepted for publication. Both corresponding and co-authors may order offprints at any time via Elsevier's WebShop (http://webshop.elsevier.com/myarticleservices/offprints). Authors requiring printed copies of multiple articles may use Elsevier WebShop's 'Create Your Own Book' service to collate multiple articles within a single cover (http://webshop.elsevier.com/myarticleservices/booklets).



    You can track your submitted article at http://help.elsevier.com/app/answers/detail/a_id/89/p/8045/. You can track your accepted article at http://www.elsevier.com/trackarticle. You are also welcome to contact Customer Support via http://support.elsevier.com.

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