Guide for Authors

  • All journal information and instructions compiled in one document (PDF) in just one mouse-click Author information pack

    • GENERAL INFORMATION
    • PUBLISH AHEAD OF PRINT - ONLINE FIRST ARTICLES
    • MANUSCRIPT SUBMISSION
    • Confidentiality
    • Copyright
    • Financial Disclosure
    • Role of the Funding Source
    • Funding Body Agreements and Policies
    • Open Access (OA)
    • Human and Animal Research
    • Registration of Clinical Trials
    • PubMed Central Repository Requirement for NIH-Funded Research
    • MANUSCRIPT PREPARATION
    • Title Page
    • Abstract
    • Text
    • CME
    • Acknowledgments
    • References
    • Tables
    • Illustrations
    • Manipulation of Images
    • Permissions
    • Online-Only Supplemental Materials
    • MANUSCRIPT CATEGORIES
    • Original Articles
    • Review Articles
    • Solicited Review
    • Concise Review for Clinicians
    • My Treatment Approach
    • Consensus Guidelines
    • Special Articles
    • Commentary
    • Brief Report
    • Editorials
    • Letters to the Editor
    • Medical Images
    • Symposium
    • Case Reports
    • Residents' Clinics
    • REVISIONS
    • ACCEPTANCE
    • REPRINTS
    • VIDEOS
    • IMMEDIATE ACCESS
    • EMBARGO

    GENERAL INFORMATION

    One of the premier peer-reviewed clinical journals in general medicine, Mayo Clinic Proceedings is among the most widely read and highly cited scientific publications for physicians, with a circulation of approximately 125,000. While the Proceedings is sponsored by Mayo Clinic, it welcomes submissions from authors worldwide, publishing articles that focus on clinical medicine and support the professional and educational needs of its readers.

    Continuously published since 1926, Mayo Clinic Proceedings' content includes Nobel-prize-winning research. The Proceedings has an impact factor of 5.812 and is ranked #11 of 150 journals in the Medicine, General and Internal category.

    Mayo Clinic Proceedings welcomes manuscripts that focus on clinical and laboratory medicine, health care policy and economics, medical education and ethics, and related topics.

    All inquiries regarding journal policy should be directed to the Editorial Office at (507) 284-2094, Monday through Friday from 8:00 AM to 5:00 PM Central time.

    PUBLISH AHEAD OF PRINT - ONLINE FIRST ARTICLES

    Mayo Clinic Proceedings publishes select articles ahead of print publication. This program is entitled Online First. All articles published are in final format and have been approved by the author(s) and editors prior to release to the website. Online First articles receive a unique DOI (Digital Object Identifier) number that facilitates searches of electronic databases. The official publication date is the date of electronic publication. These articles are print published in a subsequent issue of the Proceedings.

    MANUSCRIPT SUBMISSION

    Manuscripts are submitted online at http://mc.manuscriptcentral.com/mayoclinproc. If you are unsure about whether you have an account or have forgotten your password, enter your e-mail address into the "Password Help" section of the login screen. If an account has already been established, you will receive an e-mail with your account information. If you do not have an account, click on the "Create Account" link.

    Once you have successfully logged in, click on "Author Center," then on "Click here to submit a new manuscript." Follow the steps and instructions provided. If you are interrupted during the submission process, your work will automatically be saved and you can return to your Author Center at a later time to finish the submission process. Required metadata pertaining to the manuscript include the name, address, telephone number, and e-mail address of the corresponding author and all contributing authors; affiliated institutions; title of the manuscript; abstract; and key words. If authors wish, they may provide optional information that includes preferred and nonpreferred reviewers. Mayo Clinic Proceedings reserves the right of final reviewer selection. Once your manuscript has been completely submitted, a manuscript number will be assigned and used in all correspondence. The Editorial Office is automatically notified of the submission and sends an e-mail confirming the submission of the manuscript to the author(s).

    Each manuscript submission should designate one corresponding author and all contributing authors. Authorship must be limited to those who have contributed substantially to the design of the study, analysis of the data, and writing of the article. Authors must disclose any potential financial or ethical conflicts of interest regarding the contents of the submission.

    Mayo Clinic Proceedings accepts no responsibility for manuscripts that are lost or destroyed through electronic or computer problems. Authors are encouraged to keep copies of submitted manuscripts, including figures. If an author does not receive confirmation of submission within 48 hours, he or she should contact the Editorial Office at (507) 284-2094. If notice has not been received, the manuscript has not been completely submitted.

    All manuscripts are reviewed by Editorial Board members. Initial editorial reviews usually are completed within 1 to 2 weeks of manuscript submission. Once the Editorial Board review is complete, manuscripts are either forwarded on to peer review or rejected. Before a manuscript is sent for peer review, it is processed through CrossCheck, a text-matching software service.

    The time required for review of revised manuscripts varies. Decisions on acceptance or rejection are communicated only by e-mail to the corresponding author. The assigned manuscript number allows authors to view the status of their manuscripts through each step of the process.

    Confidentiality

    Mayo Clinic Proceedings uses a single-blinded review process. Reviewer identities are not, and should not be, disclosed to the authors or other reviewers. In addition, authors should not contact those whom they presume to be reviewers of their manuscript.

    Copyright

    Authors will be asked to complete electronic copyright disclosure forms after the manuscript is accepted for publication. Each author will receive an e-mail request to submit an electronic copyright transfer agreement through the ScholarOne Manuscripts system. Your manuscript will not begin the production process until all copyright forms have been submitted. Authors who have not received this request within 24 hours after acceptance should first check their spam folders for the notice before contacting the journal office at mcproceedings@mayo.edu. Neither administrative assistants nor other authors can sign on someone else's behalf. By completing the copyright disclosure form, you are entering a digital signature that you have read and understood the form and agree to the terms and conditions set forth. You may also print a copy for your records.

    For information about using your published material, please see Author Rights & Responsibilities.

    Financial Disclosure

    Any author who has a financial involvement with any organization or entity with a financial interest in or in financial competition with the subject matter or materials discussed in the manuscript should disclose that affiliation. Examples of financial involvement include employment, stock holdings (≥$10,000 or ≥5% equity interest in a company) consultancies, financial support of research through grants or contracts, participation in a speaker's bureau, provision of expert testimony, or receipt of honoraria. All authors should prepare a statement revealing any such financial affiliations and include it with the manuscript submission. The manuscript should also clearly identify the financial support of the research described in the currently submitted manuscript.

    Role of the Funding Source

    You are requested to identify who provided financial support for the conduct of the research and/or preparation of the article and to briefly describe the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. If the funding source(s) had no such involvement then this should be stated. Please see http://www.elsevier.com/funding.

    Funding Body Agreements and Policies

    Elsevier has established agreements and developed policies to allow authors whose articles appear in journals published by Elsevier, to comply with potential manuscript archiving requirements as specified as conditions of their grant awards. To learn more about existing agreements and policies please visit http://www.elsevier.com/fundingbodies.

    Open Access (OA)

    This journal offers authors a choice in publishing their research:

    Open Access
    • Articles are freely available to both subscribers and the wider public with permitted reuse
    • An Open Access publication fee is payable by authors or their research funder
    Subscription
    • Articles are made available to subscribers as well as developing countries and patient groups through our access programs (http://www.elsevier.com/access)
    • No Open Access publication fee

    All articles published Open Access will be immediately and permanently free for everyone to read and download. Permitted reuse is defined by the following Creative Commons user license:
    Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND): for non-commercial purposes, lets others distribute and copy the article, and to include in a collective work (such as an anthology), as long as they credit the author(s) and provided they do not alter or modify the article.

    Elsevier has established agreements with funding bodies, http://www.elsevier.com/fundingbodies. This ensures authors can comply with funding body Open Access requirements, including specific user licenses, such as CC BY. Some authors may also be reimbursed for associated publication fees. If you need to comply with your funding body policy, you can apply for the CC BY license after your manuscript is accepted for publication.

    To provide Open Access, this journal has a publication fee which needs to be met by the authors or their research funders for each article published Open Access.

    Your publication choice will have no effect on the peer review process or acceptance of submitted articles.

    Human and Animal Research

    All human studies must contain a statement within the Patients and Methods section indicating that the study has been approved by an institutional review board and that participants have signed written informed consent or that the institutional review board has waived the need for informed consent. Mayo Clinic Proceedings does not publish manuscripts on animal research.

    Registration of Clinical Trials

    Mayo Clinic Proceedings requires registration for all clinical trials submitted for publication. Trials that start enrollment after July 1, 2008, should be registered before starting patient enrollment. Clinical trials will need to be registered in 1 of the 5 registries accepted by the International Committee of Medical Journal Editors (ICJME) or in any of the primary registries that participate in the WHO International Clinical Trial Registry Platform. For additional information, please see http://www.icmje.org/recommendations/browse/publishing-and-editorial-issues/clinical-trial-registration.html.

    PubMed Central Repository Requirement for NIH-Funded Research

    The National Institutes of Health requires all articles stemming from NIH-funded research to be submitted to the PubMed Central repository 12 months after publication. Without the PubMed Central ID (PMCID) number, the article will not be counted as evidence of progress on progress reports for NIH grants. For more information on this policy, see http://publicaccess.nih.gov. Please also see the http://www.elsevier.com/about/publishing-guidelines/policies/open-access-policies/funding-body-agreements/elsevier-nih-policy-statement.
    As a service to our NIH-funded authors and in compliance with this requirement, manuscripts are deposited on a rolling basis to the PubMed Central repository once they have been received by Elsevier, our publisher. However, the manuscript does not appear online until 12 months after publication per Elsevier's agreement with PubMed Central.

    MANUSCRIPT PREPARATION

    Authors should prepare manuscripts in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals," developed by the ICJME (Ann Intern Med. 1997;126:36-47 or www.icmje.org). Reports of randomized controlled trials should include the CONSORT flow diagram (Ann Intern Med. 2001;134:657-662). Specific requirements for Mayo Clinic Proceedings follow.

    The manuscript should be typed in 12-point type and double-spaced throughout, and should be arranged as follows: (1) title page, (2) abstract, (3) alphabetical list of abbreviations used at least 3 times in the body of the manuscript (exclusive of abstract, figures, and tables) and their expansions, (4) text with appropriate headings and conclusion, (5) acknowledgments, (6) references, (7) legends, (8) tables (with alphabetical list of all abbreviations and their expansions as a footnote), and (9) illustrations (with separate alphabetical list of abbreviations and their expansion in legend). Manuscript pages should be numbered consecutively and labeled with the last name of the first author. The text portion of the manuscript should be saved using a word-processing program, such as a .doc or .rtf file format.

    Tables should be created using your word processor's table function. Tables can be placed at the end of your manuscript document or saved as separate files.

    Line art, including graphs and algorithms (flow charts), should be created and submitted in PowerPoint. Halftone and color images should be saved in Photoshop in .jpg, .gif, or .tiff format at 300 dpi. Figures should not be inserted or embedded into the manuscript document; rather, they should be saved and uploaded as separate files.

    Title Page

    Title: Formulate a title that reflects the content of the article. Avoid declarative statements, questions, and titles that tantalize but do not inform readers
    Authors: Include first names and middle initials, academic degrees, departmental affiliations and institutions, and current departmental and institutional affiliations for authors who have relocated since completion of the study.
    Financial support and disclosure: List all financial and material support for the research and work described in the manuscript (eg, grant number and funding agency for the project, an individual author, or both). List each author's affiliations or financial involvement (defined above) with any organization or entity with a financial interest in the subject matter discussed in the manuscript.
    Reprints and correspondence: Include name, address, and e-mail address of author to whom postpublication correspondence and reprint requests should be addressed.

    Abstract

    Abstracts should be no more than 250 words.

    For Original Articles:
    --Organize abstract in a structured format, with the following headings: Objective, Patients and Methods, Results, and Conclusion.
    --Ensure that information in each section of the abstract is in the corresponding section of the text.
    --Begin the "Objective" section of the Abstract with the word "To" and then state why you performed the study. Objective should not exceed one sentence.
    --In the Patients and Methods section of the Abstract and of the text, please provide the complete dates of the study, eg, January 1, 2000, through December 31, 2002.
    --Please provide the Clinical Trials registration number at the end of the Abstract, if applicable.

    For other contributions, abstracts should not be structured.

    Text

    --Express measurements in conventional units, giving conversion factor to SI units on first mention.
    --Give exact P values, even if they are nonsignificant. Round P values to 2 digits; if the first 2 or 3 numbers after the decimal point are zeroes, then round to 3 or 4 digits, respectively.
    --Avoid specialized jargon and abbreviations; abbreviate a term only if it is used at least 3 times in text (exclusive of abstract, tables, and figures) and define at first mention.
    --Use generic names for drugs and equipment.
    --Do not use footnotes within the text.
    --For genetic nomenclature, please follow the recommendations of the Human Genome Organisation. Approved gene symbols, descriptions, and older aliases can be searched at www.genenames.org.
    --For gene mutations, please see the HGVS website (at www.hgvs.org [use the Recommendations Including Nomenclature Guidelines link] or http://www.hgvs.org/rec.html).

    CME

    --To fulfill criteria of the Accreditation Council for CME, each article offering CME credit (ie, Concise Review for Clinicians and Symposium) must adhere to the following standards of practice.
    --Safeguards Against Bias: CME must give a balanced view of therapeutic options. Use of generic drug names is preferred. If educational material or content includes trade names, then trade names from several companies should be used where available, not just trade names from a single company.
    --Content Validation: All recommendations involving clinical medicine must be based on evidence that is accepted within the profession of medicine as adequate justification for their indications and contraindications in the care of patients. All scientific research referred to, reported or used in support or justification of a patient care recommendation must conform to the generally accepted standards of experimental design, data collection and analysis.
    --Educational Materials: Educational materials cannot contain any advertising, trade names, or product-group messages.

    Specific requirements: In a separate document, provide the following components:
    - 3 learning objectives.
    --5 brief CME-type questions on the subject reviewed that fall within the parameters of the defined objectives.
    --For each question, provide 5 multiple-choice answers (identify 1 best answer for each question). Do not use "all of the above," "none of the above," or combined answers (b and c) as answer choices.
    --Please read and follow the CME Requirements before submitting your manuscript.

    Acknowledgments

    The corresponding author must provide assurance in writing that permission has been obtained from those acknowledged.

    References

    --Authors are responsible for the accuracy and completeness of their references and for their complete and accurate citation in the text.
    --Cite references, figures, and tables consecutively as they appear in the text; use superscript numerals for text citations. Tables and Figures (including Supplemental eTables and eFigures) are considered part of text and so citations are numbered consecutively with those in text. Example: If Table 1 contains references, and the reference number in the text before citation of Table 1 is 5, a reference in Table 1 would become reference 6; the next reference cited in manuscript after table call-out would be cited as reference 7.
    --Cite personal communications (specify oral or written) and unpublished data parenthetically in the text and include date (do not list in references). The corresponding author must provide assurance in writing that permission has been obtained from those acknowledged.
    --In the reference list, include names and initials of all authors (if more than 6, list 3 followed by "et al"), the title, source (journal abbreviations should conform to those in Index Medicus), year, volume, issue, and expanded page ranges. For appropriate reference style, refer to a recent issue of the journal www.mayoclinicproceedings.org or the American Medical Association Manual of Style: A Guide for Authors and Editors, 10th ed. New York, NY; Oxford University Press; 2007:39-79.

    Reference Style
    Journals (Print)
    1. Rainier S, Thomas D, Tokarz D, et al. Myofibrillogenesis regulator 1 gene mutations cause paroxysmal dystonic choreoathetosis. Arch Neurol. 2004;61(7):1025-1029.
    Journals (Online)
    2. Duchin JS. Can preparedness for biologic terrorism save us from pertussis? Arch Pediatr Adolesc Med. 2004;158(2):106-107. Available at http://archpedi.ama-assn.org/cgi/content/full/158/2/106. Accessed June 1, 2004.
    Journals (Published Online Ahead of Print) 3. Cannon CP, Braunwald E, McCabe CH, et al; Pravastatin or atorvastatin evaluation and infection therapy-thrombolysis in myocardial infarction 22 Investigators. intensive vs moderate lipid lowering with statins after acute coronary syndromes [published online ahead of print March 8, 2004]. N Engl J Med. 2004;350(15):1495-1504. doi:10.1056/NEJMoa040583.
    Chapter
    4. Bithell TC. Hereditary coagulation disorders. In: Lee GR, Bithell TC, Foerster J, Athens JW, Lukens JN, eds. Wintrobe's Clinical Hematology. Vol 2. 9th ed. Philadelphia, PA: Lea & Febiger; 1993:1422-1472.
    Book
    5. Guyton AC. Textbook of Medical Physiology. 8th ed. Philadelphia, PA: WB Saunders Co; 1991:255-262.
    Web
    6. International Society for Infectious Diseases. ProMED-mail website. www.promedmail.org. Accessed April 29, 2004.

    Tables

    --Number tables consecutively (with Arabic numerals) in the order of their citation in the text.
    --Type all tabular material double-spaced; each table should be on a separate page.
    --Provide a title for each table; define all abbreviations used in each table in a footnote.
    --Superscripted lowercase letters (a-z) should be used for table footnotes.
    --Do not submit tables as images.

    Illustrations

    --Cite all illustrations in the text and number them (with Arabic numerals) in the order of their appearance.
    --Provide a legend for each figure as part of the manuscript document. Include definitions of any abbreviations that appear on the figure, along with any permissions noted, and an appropriate citation.
    --For photomicrographs, specify stain and original magnification.
    --For any illustration with a recognizable patient, submit a release form signed by the patient.
    --Do not trim illustrations or assemble component parts.
    --We do not publish pie charts; three-dimensional figures are not acceptable; hatching should be avoided on bar graphs.
    --Line art, including graphs and algorithms (flow charts), should be created in PowerPoint.
    --Halftone and color images should be saved in Photoshop in .jpg, .gif, or .tiff format at 300 dpi.
    --Illustrations borrowed from a source not copyrighted by Mayo Foundation require permission and credit line information from the publisher. See "Permissions" below.
    --Any figures submitted in color will appear in color in print and online at no additional charge to the author.

    Manipulation of Images

    Mayo Clinic Proceedings follows Elsevier’s policy on manipulation of images (http://www.elsevier.com/author-schemas/artwork-and-media-instructions). No specific feature within an image may be enhanced, obscured, moved, removed, or introduced. Adjustments of brightness, contrast, or color balance are acceptable if and as long as they do not obscure or eliminate any information present in the original. Manipulating images for improved clarity is accepted, but manipulation for other purposes could be seen as scientific ethical abuse and will be dealt with accordingly. (Rossner and Yamada, 2004. The Journal of Cell Biology, 166, 11-15. http://jcb.rupress.org/content/166/1/11.full)

    Permissions

    --Use of previously published graphic and tabular material is strongly discouraged.
    --Authors are responsible for obtaining permission for reuse of material (illustrations, tables, or lengthy quotes) from other sources, including adaptations. The preferred and quickest method for obtaining permission is via the Copyright Clearance Center. Alternatively, you may utilize our Permission Request Form.
    --Permission letters from the copyright holder of the original source (along with complete bibliographic information) must be submitted with the manuscript. Failure to provide all appropriate permissions will delay publication or may necessitate the omission of a figure or table for which permission has not been received.

    Online-Only Supplemental Materials

    Publication of online supporting material is at the discretion of the Editorial Board. Online supplemental material will not be edited by the journal office, and it is the author's responsibility to ensure the accuracy of the data and the clarity of the format. Once accepted for publication, authors will not be provided an opportunity to review or modify online supplemental material.

    Use the headings Supplemental Table, Supplemental Figure, or Supplemental Appendix for your online supporting material, and save and upload a PDF version of this material.

    The following disclaimer is listed on the Journal's website: Supplemental material attached to journal articles has not been edited, and the authors take responsibility for the accuracy of all data.

    Authors are responsible for ensuring the following:
    --Data (including percentages) are accurate and consistent with those cited in the manuscript.
    --Permission from the original publisher is obtained and sent to the journal office for any borrowed material. The works from which figures or tables are borrowed should be cited in the reference list. A credit line should be added to the figure legend or after the table footnotes in the following format: "From Title of Journal,1 with permission."
    --Supplemental figures and tables meet the same formatting specifications as those for the print journal. For example, three-dimensional figures are not acceptable, hatching should be avoided on bar graphs, and pie charts are not acceptable. Do not submit tables as images.
    --All online supplemental material is correctly called out in the body of the manuscript in the appropriate location (eg, Supplemental Table 1, Supplemental Figure 1, Supplemental Appendix 1).
    --All references cited in the online supplement are included in the reference list of the manuscript and are cited in order (based on the first occurrence of the callout to that supplemental document). Proper format for citing reference in table or figure: Smith et al,14 2010.
    --A title for each table and a legend for each figure are provided and all abbreviations are expanded in the table footnote or figure legend.
    --Table footnotes should be superscripted lowercase letters (a-z).

    MANUSCRIPT CATEGORIES

    Guidelines for the most frequent types of articles submitted to the journal are summarized below. Specific limits for word count, references, tables, and figures are provided in table format for quick reference. Authors are required to include the word count of the text, and the number of references, tables, and figures, on the Title page of the manuscript.

    Original Articles

    These include prospective clinical trials, laboratory research, retrospective clinical analyses (eg, case series), meta-analyses, and related research. Priority for publication is given to those manuscripts with original and novel findings, particularly related to the clinical care of patients. In addition to peer review, original manuscripts will undergo statistical review by either a master's or doctorate degree statistician.

    Review Articles

    These consist of a critical assessment of literature and existing data. Priority for publication is given to topics with relevance to the clinical care of patients, the advancement of medical science, or improvements in health care delivery and economics. Authors are strongly encouraged to describe within the abstract and manuscript text the methods used to focus their search of the literature (eg, PubMed, MEDLINE), the search terms used, and the date limitations of the search. Also, please indicate how studies were selected for inclusion in the review. Provide 3-5 take home points. These points should emphasize why our audience should read your article, describe what is new or cutting edge, and how it is of interest to your colleagues. The manuscripts most competitive for publication will introduce novel ideas or refreshing speculative syntheses and will address topics of importance to large numbers of patients, evolving medical issues, or mechanistically important topics. Mayo Clinic Proceedings is not interested in publishing material that can be readily obtained from existing book chapters or topics that have recently been published in other large-circulation medical journals.

    Solicited Review

    The Editorial Board can solicit a review on any topic, and in any format, deemed appropriate, as determined by a needs-assessment analysis. In general, topics are solicited for their importance and timeliness, and authors are invited based on their expertise. Even after manuscripts are solicited, acceptance for publication is at the discretion of the Editorial Board. Hence, even though the acceptance rate for a solicited review would be expected to be greater than for unsolicited material, acceptance of solicited reviews is neither guaranteed nor universal.

    Concise Review for Clinicians

    This section presents brief but informative updates on common subjects of relevance to practicing physicians. Specifically, although the topics are chosen for relevance to the journal's entire readership, they are targeted particularly to primary care physicians. A busy practitioner should be able to read the article in less than 15 minutes and obtain several good clinical tips; hence, authors should avoid describing technical details. The goals of this section are to provide practical material and to encourage application of the information by presenting questions that highlight important facts from each review. A maximum of 3 authors are allowed for a Concise Review manuscript, provided that all of the authors played a major role in the writing of the manuscript.

    Continuing medical education (CME) credit is offered with the Concise Review for Clinicians section. Please see the section entitled CME Requirements for specific details.

    My Treatment Approach

    This contribution is written by one or more recognized experts in the field. If there is more than one author, all authors should be recognized experts with similar stature in the field. The article should offer a step-by-step guide on how they would approach a patient with a given condition, based on their clinical experience and expertise. Involvement of medical writers, editors, or researchers supported by the pharmaceutical industry is not acceptable for My Treatment Approach articles.

    Consensus Guidelines

    This contribution will be written by a large group of investigators who are specialists in a given treatment area and who base their recommendations on a thorough survey of the existing literature and on their collective clinical expertise in cutting-edge approaches to contemporary medical care. This type of article will be most valuable if it addresses evolving or controversial topics and if authored by recognized authorities or authoritative groups.

    For both My Treatment Approach and Consensus Guidelines contributions, the Editorial Board will recruit these articles and authors on the basis of a needs assessment survey. Potential authors who wish to have their ideas vetted for this series should petition the Editorial Board before they begin writing. Manuscripts will be considered for publication only after they have passed the journal's rigorous peer-review process and Editorial Board oversight. These 2 article types are published under the main article heading of Diagnosis and Treatment Guidelines.

    Special Articles

    Designation as a Special Article is at the discretion of the Editorial Board. In general, Special Articles address important, evolving, highly visible, and often controversial topics (eg, the 2000 article on Gulf War illnesses). Individual articles may contain an amalgam of literature review, new original data, and speculative synthesis, with some opportunity for injecting the authors' opinions. As such, the article content may be more closely aligned with the Original Articles or Reviews, but with some features of Editorials or Commentaries.

    Commentary

    Commentaries are intended to offer expert insights into important or controversial topics related to clinical medicine, medical economics, governmental policy, ethics, or related issues. When appropriate, the Editorial Board expects authors to acknowledge a limited amount of supporting or opposing literature. Priority is given to novel thought, clear and creative writing, and the relevance of the manuscript to the interests of Proceedings' readers.

    Brief Report

    A Brief Report will typically address an early report or observation of relevance to clinical medicine or medical science. This category is not intended to present preliminary data on structured, ongoing research but instead is intended to present unanticipated or extremely novel observations that may encourage others to perform related research or reassess their clinical practice.

    Editorials

    Submission of Editorials is by invitation from, or prior arrangement with, the Editorial Board. Most Editorials will comment on other material (eg, an innovative original article) appearing in the same issue of the journal or on changes in journal activities or policies. "Freestanding" editorials that comment on other topics, such as major changes in clinical medicine or health care policy, not originally introduced within the pages of the Proceedings, are also published. Final acceptance of any Editorial, even an invited Editorial, is at the discretion of the Editorial Board.

    Letters to the Editor

    The Editor welcomes letters and comments, particularly pertaining to recently published articles in Mayo Clinic Proceedings, as well as letters reporting original observations and research. Letters pertaining to a recently published Proceedings article should be received no later than 1 month after the article's publication. It is assumed that appropriate letters submitted to the Editor will be published, at the Editor's discretion, unless the writer indicates otherwise. Priority is given for the importance of the message, novelty of thought, and clarity of presentation. The Editor reserves the right to edit letters in accordance with Proceedings style and to abridge them if necessary.

    Medical Images

    A Medical Image consists of a publication-appropriate photograph, photomicrograph, radiograph, or other type image, accompanied by a paragraph or 2 of descriptive text. Priority is given to importance of the topic, clarity of the images and message, and aesthetics. Authorship is limited to 2 authors. A minimum of 4 images with a maximum of 8 images may be submitted. Provide a brief legend (60 characters or less) to accompany each separate image. In addition, authors should clearly indicate 1 or 2 images to be included in the formatted online article. The remaining images and legends, if provided, will be rotated on the journal's website. All images should be submitted as 300 dpi. Medical Images will be published online only and although the full text will appear online only, the title and author(s) of each eMedical Image will be listed in the print table of contents. eMedical Images will continue to be peer reviewed and edited, will be assigned a DOI (Digital Object Identifier) number, and will be indexed on PubMed.

    Symposium

    Symposium articles are a collection of manuscripts addressing a common topic (eg, geriatrics, antimicrobial agents, cerebrovascular disease), and typically 1 or 2 manuscripts of the series are published per month, sequentially over many months, until the series is completed. Symposium topics are determined well in advance of publication by the Editorial Board, and submission of symposium articles is by invitation only. Individuals interested in identifying symposium topics or specific symposium manuscripts are encouraged to contact the editorial office. CME credit is offered with symposium articles. Please see the section entitled CME Requirements for specific details.

    Case Reports

    Case Reports should be approximately 800 to 1800 words (up to 7 typed, double-spaced pages). Case reports must include an unstructured abstract. The number of references, tables, and figures should be appropriate for the overall length of the paper. In general, no more than 2 tables or 2 figures are necessary. To better select the highest-quality case reports, the editorial board of Mayo Clinic Proceedings has revised and codified our policies for case report review and the standards for acceptance. Manuscripts of the "case report and review of the literature" genre will not be accepted. Other case reports must first demonstrate relevance to the interest of the Mayo Clinic Proceedings readership and importance of the message before they are sent for further review.

    Publication priority will be given to case reports that identify:

    • A first-of-its-kind, unexpected, or unusual observation of a disease process that is relevant to a meaningful number of patients, such as:
      a new disease or syndrome
      a previously unknown or important manifestation of a common disease
      a new understanding of the pathophysiology of a common disease
    • A new or first observation of an important adverse effect of a commonly used drug
    • New therapeutic activity of a new treatment, including drug and non-drug therapies.

    A small fraction of manuscripts rejected for publication as case reports, but offering some incremental advances in knowledge, may, if appropriately novel, be given priority for conversion to a letter to the editor.

    Residents' Clinics

    The Residents' Clinic section of Mayo Clinic Proceedings is strictly an educational tool for Mayo Clinic residents and fellows, and submissions are limited to categorical Internal Medicine Residents as first authors. As such, this is the only portion of the journal in which affiliation with Mayo Clinic is necessary. Submissions of Residents' Clinic manuscripts from external authors not affiliated with Mayo Clinic will be automatically rejected. Please read and follow the detailed Residents' Clinic Instructions before submitting your manuscript.

    REVISIONS

    Enter your Author Center and click on "Manuscripts with Decisions." Locate the appropriate manuscript and click on the "Create a Revision" link. This will create a revision draft with a .R1, .R2, etc. extension. On the first screen, respond to the reviewer's comments in the section entitled "Comments to Decision Letter." Verify the accuracy of the article type, title, abstract, authors, and keywords. Complete the checklist on the Details and Comments screen. On the File Upload screen, delete any original files that are not pertinent to the revised manuscript and upload the revised manuscript files. View the HTML and PDF versions of the manuscript to ensure accuracy and click the Submit button when finished. You will receive an e-mail confirmation that the revised manuscript has been successfully submitted.

    ACCEPTANCE

    All accepted manuscripts are edited according to the American Medical Association Manual of Style: A Guide for Authors and Editors, 10th ed. New York, NY; Oxford University Press; 2007, and the corresponding author will receive an approval copy of the page proofs before publication.

    REPRINTS

    Journal corresponding authors will receive a free PDF of their own articles for personal use only. A form for ordering paper reprints will accompany the author acknowledgement e-mail from the Publisher.

    VIDEOS

    We have the capacity to link a video with your article on our website. Articles with a video tend to have higher online readership. Videos should have an educational, not commercial, purpose. Interviews, a presentation of the highlights of the article, and an illustration of a given procedure would all be appropriate subjects for videos. For information about using your published material, please see Author Rights & Responsibilities.
    --Videos are considered to be part of the article and should not have been previously "published" (posted on another journal's website) or permission must be obtained for reuse.
    --Files should be in .wmv or .avi format. Typically, they should be no larger than 10 MB and no longer than 5 minutes. Minimum dimensions for the video should be 320 pixels wide by 240 pixels deep. Please verify that videos are viewable in QuickTime or Windows MediaPlayer.
    --Videos should be uploaded at the time of submission with the manuscript files via Manuscript Central http://mc.manuscriptcentral.com/mayoclinproc. If you experience difficulty uploading the file, please submit the video file separately offline to the Editorial Office at mcproceedings@mayo.edu.

    IMMEDIATE ACCESS

    For a fee of $3000, authors have the opportunity to allow all visitors to our site to access the full text of their article from the day of publication.

    EMBARGO

    All information regarding the content and publication date of accepted manuscripts is confidential. Information contained in or about accepted articles cannot appear in any media outlet (print, broadcast, or electronic) until print or online publication.

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