Guide for Authors

  • The Journal of Hepatology, the official journal of the European Association for the Study of the Liver (EASL), publishes articles describing clinical and basic investigations in the field of hepatology.

    Dr Rajiv Jalan.

    Contact Information:
    Editorial Office
    7 rue Daubin
    Geneva, Switzerland
    Telephone: +41 22 807 03 67
    Fax: +41 22 510 24 00
    Editorial office e-mail:
    Manuscript submission:


    Original Manuscripts
    Original articles describing clinical and basic investigations in the field of hepatology. Manuscripts submitted in this category are expected to be concise, well organized, and clearly written.
    - The maximum length is 6,000 words, including the abstract, references, tables, and figure legends.
    - The structured abstract must not exceed 250 words.
    - The title must not exceed 130 characters.
    - In total 8 figures / and or tables are allowed.
    - References should not exceed a maximum of 100.- The abstract must be organized as follows:
    - Background & Aims
    - Methods
    - Results
    - Conclusions

    Do not use abbreviations, footnotes or references in the abstract. An electronic word count of the abstract must be included.
    - Three to ten key words at the end of the abstract must be provided.
    - The manuscript must be arranged as follows:

    • Title page
    • Abstract in the Journal of Hepatology format
    • Introduction
    • Materials and methods (or Patients and methods
    • Results
    • Discussion
    • Acknowledgements
    • References
    • Tables
    • Figure legends
    • Figures

    AudioSlides The journal encourages authors to create an AudioSlides presentation with their published article. AudioSlides are brief, webinar-style presentations that are shown next to the online article on ScienceDirect. This gives authors the opportunity to summarize their research in their own words and to help readers understand what the paper is about. More information and examples are available at Authors of this journal will automatically receive an invitation e-mail to create an AudioSlides presentation after acceptance of their paper.

    Acceptance of original manuscripts will be based upon originality and importance of the investigation. These manuscripts are reviewed by the Editors and, in the majority of cases, by two experts in the field. Manuscripts requiring extensive revision will be at a disadvantage for publication and will be rejected. Authors shall be responsible for the quality of language and style and are strongly advised against submitting a manuscript which is not written in grammatically correct English. The Editors reserve the right to reject poorly written manuscripts even if their scientific content is qualitatively suitable for publication. Manuscripts are submitted with the understanding that they are original contributions and do not contain data that have been published elsewhere or are under consideration by another journal. Meeting abstracts do not constitute prior publication.

    Review Articles
    Review articles on selected clinical and basic topics of interest for the readers of the Journal of Hepatology will be solicited by the Editors. Review articles are expected to be clear, concise and updated.

    • The maximum length is 5000 words, excluding the summary, references, tables, and figures.
    • References should not exceed a maximum of 150.
    • The inclusion of a maximum of 4 high-quality tables and 4 colored figures to summarize critical points is highly desirable.
    • Review articles must be accompanied by a title page and a summary.
    • Reviews should include at least one Key Point Box, with a maximum of 5 bullet points, that briefly summarizes the content of the review.

    Review articles are reviewed by the Editors and may be sent to outside expert reviewers before a final decision for publication is made. Revisions may be required.

    This section consists of invited brief editorial comments on articles published in the Journal of Hepatology.

    • The length of an editorial should not exceed 1500 words, excluding references.
    • A maximum of 1 table or 1 figure is allowed.
    • References should not exceed a maximum of 20.
    • A title page must be provided.

    Case Reports
    Case reports are not encouraged and will only be accepted if they represent an outstanding contribution to the aetiology, pathogenesis or treatment of a specific liver disorder. Regular case reports will not be accepted even if they provide interesting clinical information.

    • The maximum length is 3000 words, including the summary and references.
    • A maximum of 2 tables and 2 figures is allowed.
    • References should not exceed a maximum of 15.
    • A title page must be provided.

    Letters to the Editor
    Letters to the Editor will be considered for publication if they are related to articles published in recent issues of the Journal of Hepatology. Occasionally, Letters to the Editor that refer to articles not published in the Journal of Hepatology will be considered.

    • The length of a Letter to the Editor should not exceed 800 words.
    • A maximum of 1 table or 1 figure is allowed.
    • References should not exceed a maximum of 10.
    • No more than 4 Authors may appear in the author list.

    Special Sections
    The journal will contain special sections that focus on one or more specific topics within the hepatology field:

    Controversies in Hepatology. The Controversies in Hepatology section will present two opposing viewpoints on a currently controversial subject within the field. Controversies in Hepatology commentaries will be solicited by the Editors only.

    • The maximum length is 2,000 words, excluding the summary, references, tables and figures.
    • A maximum of 2 tables and 2 figures is allowed.
    • References should not exceed a maximum of 25.
    • It must be accompanied by a title page and a summary.

    Hepatology Snapshot. Hepatology Snapshot consists of a one single page figure, consisting of drawings, schematic diagrams and tables, that graphically summarizes current knowledge about a particular subject within the hepatology field. As an example, please see J Hepatol. 2012;56:990-992.
    Hepatology Snapshot commentaries will be solicited by the Editors only.

    • The figure is accompanied by a short summary article that should not exceed a maximum of 800 words, excluding tables or figures.
    • In lieu of the article, a detailed figure legend which includes all relevant background information can be included.
    • References should not exceed a maximum of 10.
    • A title page must be provided.


    Responsible reporting of research studies, which includes a complete, transparent, accurate and timely account of what was done and what was found during a research study, is an integral part of good research and publication practice and not an optional extra. The Journal of Hepatology supports initiatives aimed at improving the reporting of health research. We ask authors to use the following guidelines when drafting their manuscripts:

    CONSORT 2010 Statement: updated guidelines for reporting parallel group randomized trials.

    STROBE Statement: guidelines for reporting observational studies.

    STARD initiative: standards for reporting of diagnostic accuracy.

    PRISMA Statement: preferred reporting items for systematic reviews and meta-analyses.

    CHEERS Statement: consolidated health economic evaluation reporting standards.

    The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments.

    We ask authors to address all items recommended by the guidelines (as a minimum); where this is not possible please provide an explanation in the text to give a transparent account of your study.
    Adherence to recommended reporting guidelines will facilitate review of your manuscript, increase the probability of its successful publication, and improve the usability of research findings from your study in further research and clinical practice.

    Animal trials. Manuscripts reporting experiments using animals must include a statement giving assurance that all animals received human care and that study protocols comply with the institution's guidelines. Statistical methods used should be outlined.

    Human trials. Manuscripts reporting data from research conducted on humans must include a statement of assurance in the methods section of the manuscript reading that: (1) informed consent was obtained from each patient included in the study and (2) the study protocol conforms to the ethical guidelines of the 1975 Declaration of Helsinki as reflected in a priori approval by the institution's human research committee.

    Randomised controlled trials. Any paper that is a randomized control trial should adhere to the guidelines that can be found at the following web-site: The checklist should be printed out and faxed to the Editorial office at the time of submission. The trial registration number must be included on the title page of the manuscript reporting a registered clinical trial. Failure to do so will prevent entry to the peer review process.

    Registration of clinical trials. The Journal of Hepatology endorses the policy of the WHO and the International Committee of Medical Journal Editors (ICMJE) on the registration of clinical trials. Any trial that starts recruiting on or after July 1, 2005 should be registered in a publicly owned, publicly accessible registry and should satisfy a minimal standard dataset. Trials that started recruiting before that date will be considered for publication if registered before September 13, 2005. More detailed information regarding the definition of clinical trial, the minimal registration data set, and the requirements for an acceptable trial registry can be found in New Engl J Med 2004, 351:1250-1251 and New Engl J Med 2005, 352:2437-2438.

    Drugs and chemicals. Drugs and chemicals should be used by generic name. If trademarks are mentioned, the manufacturer's name and city should be given. All funding sources supporting the work, either public or private, especially those from pharmaceutical companies, must be provided.

    Genomic and proteomic data. The Journal of Hepatology supports the efforts of databases that aggregate published data for the use of the scientific community. Therefore, appropriate data sets (including microarray data, protein or DNA sequences) must be deposited in an approved database, and an accession number or a specific access address must be included in the published paper. We encourage compliance with MIBBI guidelines (Minimum Information for Biological and Biomedical Investigations []).

    Details include but are not limited to:

    DNA and protein sequences. Approved databases are GenBank or other members of the International Nucleotide Sequence Database Collaboration (EMBL or DDBJ) and SWISS-PROT.
    Microarray data. Data should be presented in MIAME-compliant standard format ( Approved databases are Gene Expression Omnibus ( and ArrayExpress (

    Other large datasets produced using genomics technologies (including but not limited to ChIP on Chip, Genotyping, aCGH and Tilling Arrays) must be deposited in an appropriate public repository. Please include the repository URL and the data accession number in the body of the manuscript upon submission. Data must be publicly accessible upon acceptance and publication of the manuscript as a Paper in Press. No data are to be withdrawn following publication

    Methodological and statistical instructions for authors submitting manuscripts to the Journal of Hepatology

    The manuscripts should include a complete and detailed description of what was done. This includes a description of the design, measurement and collection of data, the study objective and major hypotheses, type and source of subjects, inclusion and exclusion criteria and measures of outcome, number of subjects studied and why this number was chosen. Any deviation from the study protocol should be stated. The baseline characteristics of any compared groups should be described in detail and -if necessary -adjusted for in the analysis of the outcome. For randomized clinical trials the following should also be clearly documented: treatments, sample size estimation, method of random allocation and measures taken for maintaining its concealment including blinding, numbers treated, followed-up, being withdrawn, dropping out, and having side effects (numbers and type). The statistical methods used should be relevant and clearly stated. Special or complex statistical methods should be explained and referenced. Complex analyses should be performed with the assistance of a qualified statistician. Unqualified use of such analyses is strongly discouraged. The underlying assumptions of the statistical methods used should be tested to ensure that the assumptions are fulfilled. For small data sets and if variable distributions are non-normal, distribution free (non-parametric) statistical methods should be used. The actual p values - whether significant or not - should always be presented (not NS). Confidence intervals convey more information than p values and should be presented whenever possible. Continuous variables can always be summarized using the median and range which are therefore preferred. Only in the infrequent case of a Normal distribution are the mean and standard deviation (SD) useful. Complex analyses (including Cox and logistic regression analysis) should be presented in sufficient detail: i.e. variable scoring, regression coefficients, standard errors and any constants. Odds-ratios or relative risks are not sufficient documentation of such analyses. The handling of any missing values in the data should be clearly specified. The number of statistical tests performed should be kept at a minimum to reduce spurious positive results. Explorative (hypothesis generating) analyses without confirmation using independent data are discouraged. Figures showing individual observations, e.g. scatter plots, are encouraged. Histograms may also be useful. Tables should indicate the number of observations on which each result is being based.


    The only accepted form of submission for all types of manuscripts is through the Elsevier Editorial System (EES) website Authors are kindly asked NOT to send their manuscripts by fax or mail to the Editorial Office. Should you have any queries regarding the EES please contact their 24/7 support hotline:

    Global telephone support:

    For The Americas: +1 877 839 7126
    For Japan: +81 3 5561 5037
    For Asia and Pacific: +65 6349 0222
    For Europe and rest of the world: + 44 1865 843434

    You may also find additional information at Elsevier's self-help site at: Here you will be able to search for solutions on a range of topics, find answers to frequently asked questions and learn more about EES via interactive tutorials.

    Elsevier also offers online training sessions on specific features in EES. For further information as well as a schedule of upcoming sessions, please visit the EES homepage at the Training Desk at:

    Please note: you can also provide feedback directly to:


    General formatting
    The submitted manuscript must be typed double-spaced throughout and numbered (including references, tables and figure legends). Preferably using a "standard" font (we prefer Times/Arial 12). For mathematical symbols, Greek letters, and other special characters, use normal text. The references must be in accordance with the Journal of Hepatology reference style (see References).

    Approved nomenclature for gene and protein names and symbols should be used, including appropriate use of italics (all gene symbols and loci, should be in italics) and capitalization as it applies for each organism's standard nomenclature format, in text, tables, and figures. Full gene names are generally not in italics and Greek symbols are not used. Proteins should not be italicized.

    Improperly prepared manuscripts will not be entered into the peer review process and will be sent back to the author for correction.

    A letter of submission must be uploaded with all manuscripts. For revised manuscripts, the letter should be uploaded into the Comments to the Editor section. This letter may be used to outline the strengths of the manuscript. All commercial relationships (i.e. consultancies, patent-licensing agreements) that might pose a conflict of interest in connection with the submitted manuscript must be included in the letter. In case of possible conflicts of interest, the letter must include a detailed description of the nature of the conflict of interest, the full name of the entity with which there is a conflict, as well as address, telephone number, webpage address, a detailed financial disclosure, and any other important, relevant details.

    Title page must contain:

    • a. A title of no more than 130 characters.
    • b. Names of the Authors including the first names of all the Authors in full.
    • c. Names of department(s) and institution(s) where the work was done.
    • d. Name, address, telephone and fax numbers, and electronic mail address of the corresponding Author.
    • e. Electronic word count.
    • f. Number of figures and tables.
    • g. List of abbreviations in the order of appearance.
    • h. A minimum of three keywords
    • i. Conflict of interest.
    • j. Financial support.
    • k. Author's contributions

    As stated in the ICMJE recommendations, credit for authorship requires:

    • (a) substantial contributions to the conception and design; or the acquisition, analysis, or interpretation of the data,

    • (b) the drafting of the article or critical revision for important intellectual content,

    • (c) final approval of the version to be published, and

    • (d) agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the article are appropriately investigated and resolved.

    Any change in authorship after submission must be approved in writing by all authors.

    All authors, and all contributors should specify their individual contributions at the end of the text (e.g., study concept and design; acquisition of data; analysis and interpretation of data; drafting of the manuscript; critical revision of the manuscript for important intellectual content; statistical analysis; obtained funding; administrative, technical, or material support; study supervision)

    References must be in accordance with the Journal of Hepatology reference style. References are ordered as they appear in the text and citation numbers for references are placed between "brackets" ("[ ]") in the text as well as in the reference list.
    Authors should be listed surname first, followed by the initials of given names (e.g. Bolognesi M). If there are more than six authors, the names of the first six authors followed by et al. should appear. Titles of all cited articles are required. Titles of articles cited in the reference list should be in upright, not italic text; the first word of the title is capitalized, the title written exactly as it appears in the work cited, ending with a full stop. Journal titles are abbreviated according to common usage, followed by Journal years, semicolon (;) before volume and colon (:) before full page range (see examples below).

    All articles in the list of references should be cited in the text and, conversely, all references cited in the text must be included in the list. Personal communications and unpublished data should be cited directly in the text by the first Author, without being numbered. Please make sure you have the latest, updated version of your reference management software to make sure you have the correct reference format for the Journal of Hepatology.

    An example of how references should look within the text:
    "HVPG was measured by hepatic vein catheterization using a balloon catheter according to a procedure described elsewhere [14,15] and used as an index of portal hypertension [16]."

    An example of how the reference list should look:
    [14] Merkel C, Bolognesi M, Bellon S, Zuin R, Noventa F, Finucci G, et al. Prognostic usefulness of hepatic vein catheterization in patients with cirrhosis and esophageal varices. Gastroenterology 1992;102:973-979.
    [15] Groszmann RJ, Wongcharatrawee S. The hepatic venous pressure gradient: anything worth doing should be done right. Hepatology 2004;39:280-282.

    Updated versions of the Journal of Hepatology EndNote® and Reference Manager® styles can be found here:RefMan:

    Figures and Tables.

    A maximum of in total 8 figures and/or tables is allowed. Figures will be often, but not always, re-designed by graphic designers. By signing and transferring the Copyright Agreement to EASL, the author gives permission to the graphic designers to alter the visual aspect of any figures, tables, or graphs. The scientific content of figures will not be altered. Please provide this information with your covering letter.

    Figures. All graphics submitted to the Journal of Hepatology should be sent at their actual size, which is 100% of their print dimension and in portrait orientation.
    Two standard widths are used and figures should fit in one (8.5 x 23.5 cm) or two (17.5 x 23.5 cm) columns (see Figure and Table Guidelines).

    Figures should be supplied in the following preferred file formats: PDF (*.pdf), Power Point (*.ppt), Adobe Illustrator (*.ai, *.eps), Photoshop (*.psd) files in grayscales or in RGB color mode. It is highly recommended that figures not be sent in JPG (*.jpg) format.
    Photographs (scans, immunofluorescences, EM, and histology images) should be submitted as: 1) TIFF (*.tif) with a resolution of at least 300 pixels per inch, or 2) Illustrator compatible EPS files with RGB color management (*.eps), 3) Photoshop (*.psd) or PDF (*.pdf) files (grayscales or RGB) at the appropriate resolution which is:

    • * 300 dpi for color figures

    • * 600 dpi for black and white figures

    • * 1200 dpi for line-art figures

    For all photomicrographs, where possible, a scale should appear on the photograph. Photographs of identifiable patients should be accompanied by written permission to publish from patient(s).

    Furthermore, panel lettering should be in Arial bold 14 pt, capitalized and no full stop (A, B) while lettering in figures (axes, conditions), should be in Arial 8 pt, lower case type with the first letter capitalized and no full stop. No type should be smaller than 6 pt. (For more detailed information, please refer to the Figure and Table Guidelines).

    If after acceptance the quality of the figures does not match the standards of the Journal, the authors will be asked to resubmit the figures at the required quality.

    Tables. Tables should be provided as Word files (*.doc) or Illustrator/InDesign (*.ai, *.eps, *.indd) compatible files. No TIFF and JPG files are acceptable for table submission. When submitting tables in Microsoft Word table function, no tab, space or colors should be used. Tables should contain a maximum of 10 columns. Tables submitted in landscape orientation will not be accepted. Tables should include a title, table legend, and if necessary footnotes. Include tables in the submitted manuscript as a separate section.

    Figure Legends. Figure legends should be listed one after the other, as part of the text document, separate from the figure files. Please do not write a legend below each figure.Each figure legend should have a brief overarching title that describes the entire figure without citing specific panels, followed by a description of each panel, and the symbols used. Enough information should be provided in the figure legend text to permit interpretation of figures without reference to the text; but should not contain any details of methods, or exceed 100 words.

    The abbreviated word for figure "Fig." should be typed and bolded, followed by the figure number and a period (i.e.., "Fig. 1."). Every figure legend should have a Title written in bold. If a figure contains multiple sections (i.e. A, B, C, D) the letter for these subsections should be in capital letters. Within the figure legend text the capital letters should be surrounded by parenthesis [i.e. (A)…(B)…(C)…(D)]. Figures should be numbered according to the order of citation.

    Supplementary material.

    Supplementary material can be uploaded during the submission process.

    The Supplementary material should have a manuscript title, list of authors, a table of contents, followed by the list of investigators (if there is one), text (such as methods), figures, tables, and then references. Supplementary material must be prepared as a single Word file with pages numbered (including references, tables and figure legends) using Times New Roman or Arial 12 pt double-spaced). Sections have to be 12 pt bold, Subsections have to be 12 pt, italics. For mathematical symbols, Greek letters, and other special characters, use normal text, NOT symbol. The references must be in accordance with the Journal of Hepatology reference style (see References).

    Figures have to be included with legends below each figure. Figure legends consist of a title (bold) and separate descriptions for reach panel, labelled by capital letters in parenthesis. Tables have to be included with Table titles (bold) on top of the Table and footnotes below. Very large Tables (e.g., microarray data) should be submitted as Excel file.

    The Supplementary material will not be edited for style.

    Supplemental movies may be submitted through Elsevier Editorial System as (*.mov), (*.avi), (*.mpeg), or (*.gif) files. By choosing the submission item labeled "Supplementary data," the PDF builder will imbed links within the PDF where editors and reviewers will be able to download the files. This also works for Excel files that do not display properly once converted to a PDF. Please note that the size limit for these items is 10 MB per file.

    Large data sets (too large to be included within the manuscript) must be submitted online. Each file should be prepared as PDF, Excel, or text. The size of the file should not exceed 10MB.

    Upon acceptance, if supplementary material does not comply with the guidelines authors will be requested to change the formatting.


    Authors may be asked to contact professionals regarding the correction of the English content of manuscripts either before or after acceptance. This expense will be the responsibility of the Authors.


    Permissions may be sought directly from Elsevier Global Rights Department:
    You may also learn more about Rights and Permissions directly through Elsevier's Permissions page:

    Review process. Authors should be aware that manuscripts will be screened upon submission. Only the manuscripts which fully comply with the submission requirements outlined and in which the level of English is of an acceptable standard will enter the peer review process.

    First submission.Once successful submission of a manuscript has taken place, an acknowledgement will be sent by e-mail to the Corresponding Author on the manuscript. All subsequent correspondence will be with the designated Corresponding Author. The number of the manuscript should be used by the Authors in all communications with the Editorial Office. All the manuscripts will be reviewed by the Editors and, and in some cases, by other expert reviewers. After review, the corresponding Author will be notified by letter of the decision taken by the Editor(s). This letter will be accompanied in most, but not all, cases by the comments of the reviewers. This letter will be sent via e-mail.

    Resubmission of manuscripts. In some cases, Authors will be invited to submit a revised version of the manuscript for further review. This invitation does not imply, in any case, that the revised version will be accepted for publication. In general, revised manuscripts must be received in the Editorial Office within four months of the date of the first decision. Authors should submit the resubmitted manuscript with all changes underlined. The resubmitted manuscript should be accompanied by a cover letter stating that the manuscript has been revised according to the comments made by the Editor and the Reviewers. Figures and tables must be uploaded. Please ensure that a separate point by point response to the reviewers is included with the covering letter. Please do not send revised manuscripts to the Editorial Office via e-mail. Revised manuscripts should be uploaded in the Elsevier Editorial System website.

    Proofs will be made available to the author(s) to be checked. It is the responsibility of the author(s) to make sure that the quality and accuracy of the manuscript, figures, and tables in the proofs is correct. Authors should return their proofs within 48 hours, by fax or e-mail if the corrections are minor, to expedite publication. All questions arising after acceptance of a paper, especially those concerning proofs, should be directed to the Publisher, Elsevier, Radarweg 29, 1043 NX Amsterdam, The Netherlands, tel.: +31 (0)20 485 2533, fax: +31 (0)20 485 2521, e-mail: Further changes or additions to the edited manuscript after these corrections cannot be accepted.


    Cover illustrations will be chosen by the Editors. Authors are highly encouragedto submit high quality color figures and images suitable for publication on the cover at the time of submission of the manuscript.


    Submission and publication is free of charge. Journal of Hepatology has a graphic design team that is responsible for re-stylizing all tables, charts, and figures to improve the readability and presentation of the Journal, as well as to give it a unique style that is present across all articles. This service is free of charge. Color figures using colors different from the Journal colors (e.g. Immunofluorescence, photographs) are charged with 200 euro for the first color figure and with 100 for each consecutive color figure in the same article if the figures appear in color in the printed version. Color figures online only are free of charge.For open access publication please contact the Editorial Office:


    Reprints must be ordered in advance. An order form indicating the cost of the reprints is sent from the Publisher with page proofs. Reprint orders, payments, and inquiries must be forwarded to the Publisher, not to the Editorial Office.


    Announcements of meetings that could be of interest to the readers of the Journal of Hepatology should be sent to the Editorial Office at least 4 months before the date of publication. Short announcements are published free of charge. Large announcements are considered as advertising and the prices vary according to the size and the number of insertions.


    Information about advertisements in the Journal of Hepatology can be obtained from the Publisher.

    Copyright assignments, Financial disclosures, and Institutional Review Board/Animal Care Committee Approval. Upon article acceptance, the corresponding author will be contacted and asked to submit the above forms. It is the author's responsibility to make sure these forms are signed and duly returned to the editorial office via fax. If these forms are not received the manuscript will NOT be published.

    Drug Declaration/Conflict of Interest Form

    This form should be printed out and the suitable statement chosen among the listed ones (A-G). It should then be signed by the corresponding author and faxed to the Editorial Office at +41 22 510 24 00. If this form is not received the paper will NOT be published.


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