Submission of an article to the Journal of Clinical Virology implies that the work described has not been published previously (except in the form of an Abstract or as part of a published lecture or academic thesis), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, without the written consent of the Publisher.

Manuscripts that cover subjects well studied in the literature that do not make an obviously fresh point or those which primarily confirm previous findings but in a different geographical area, are likely to be rejected unless there are novel clinical implications or they cover a hot new topic (eg a new virus). In cases of doubt, please contact either of the Editors in Chief.

If you are unsure as to the suitability of your article for publication in the JCV, please send either one of the Editors-in-Chief a copy of your Abstract by E-mail. They will then advise you on whether or not your work would be appropriate for publication.

Articles may only be submitted through the online submission system available at http://ees.elsevier.com/jcv. Authors submitting paper articles will be contacted and requested to submit online.

To avoid unnecessary delays with their manuscript authors should adhere strictly to the following instructions.

- Indicated the type of article submitted.
- Manuscript and abstract (according to the Guide for Authors) are complete and uploaded.
- The structure of the manuscript and abstract is correct for each article type, see link here
- All text pages, keywords, artwork, tables and figure captions have been included and appear correctly in the pdf.
-All tables and figures are uploaded as separate files.
- Colour figures are clearly marked as being intended for colour or black-and-white reproduction
- Please use decimal points rather than commas for numbers.
-The metric system is to be used throughout.- Please write your text in good English (American or British usage is accepted, but not a mixture of these).
- Manuscript is spell-checked and within the word limit for the type of article.
-Manuscripts should be submitted in double line spacing and the lines and pages should be numbered.
- References are in the correct format for the journal. Citations in the text are numbered superscripts.
- References mentioned in the reference list are cited in the text and vice versa.
- Permission has been obtained for use of copyrighted material from other sources (including the Web).
- Always keep a backup copy of the electronic file for reference and safety. The text should be in single-column format. Keep the layout of the text as simple as possible. Most formatting codes will be removed and replaced on processing the article. In particular, do not use the program's options to justify text or to hyphenate words. However, do use bold face, italics, subscripts, superscripts etc. Do not embed 'graphically designed' equations or tables, but prepare these using your word processing program's facility.
- Ensure that the letter 'l' and digit '1' (also letter 'O' and digit '0') have been used properly, and structure your article (tabs, indent, etc.) consistently. Characters not available in your word processing program (Greek letters, mathematical symbols, etc.) should not be left open but indicated by a unique code (e.g., gralpha, @, #, etc., for the Greek letter alpha). Such codes should be used consistently through the entire text. Please make a list of such codes and provide a key

Conflict of Interest
The Editors of the Journal of Clinical Virology require that submissions contain a Conflict of Interest Declaration. Upon submission you will be required to complete and upload this form (word version or pdf version) to declare funding, conflict of interest and to indicate whether ethical approval was sought. This information must also be inserted into your manuscript under the acknowledgements section with the headings below. If you have no declaration to make please insert the following statements into your manuscript:
Funding: None
Competing interests: None declared
Ethical approval: Not required
Articles of the following types are accepted by the Editors. Please follow link for detailed information on requirements for all article types.

Submission declaration and verification
Submission of an article implies that the work described has not been published previously (except in the form of an abstract or as part of a published lecture or academic thesis or as an electronic preprint, see http://www.elsevier.com/postingpolicy), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere in the same form, in English or in any other language, including electronically without the written consent of the copyright-holder. To verify originality, your article may be checked by the originality detection service CrossCheck http://www.elsevier.com/editors/plagdetect.

Contributors
Each author is required to declare his or her individual contribution to the article: all authors must have materially participated in the research and/or article preparation, so roles for all authors should be described. The statement that all authors have approved the final article should be true and included in the disclosure.

Authorship
All authors should have made substantial contributions to all of the following: (1) the conception and design of the study, or acquisition of data, or analysis and interpretation of data, (2) drafting the article or revising it critically for important intellectual content, (3) final approval of the version to be submitted.

Changes to authorship
This policy concerns the addition, deletion, or rearrangement of author names in the authorship of accepted manuscripts:Before the accepted manuscript is published in an online issue: Requests to add or remove an author, or to rearrange the author names, must be sent to the Journal Manager from the corresponding author of the accepted manuscript and must include: (a) the reason the name should be added or removed, or the author names rearranged and (b) written confirmation (e-mail, fax, letter) from all authors that they agree with the addition, removal or rearrangement. In the case of addition or removal of authors, this includes confirmation from the author being added or removed. Requests that are not sent by the corresponding author will be forwarded by the Journal Manager to the corresponding author, who must follow the procedure as described above. Note that: (1) Journal Managers will inform the Journal Editors of any such requests and (2) publication of the accepted manuscript in an online issue is suspended until authorship has been agreed.After the accepted manuscript is published in an online issue: Any requests to add, delete, or rearrange author names in an article published in an online issue will follow the same policies as noted above and result in a corrigendum.

Additional Information

Title page
The title page should include: the name(s) of the author(s), their full postal addresses, a footnote indicating (by asterisk) to whom correspondence should be sent, telephone and fax numbers, E-mail address, and a footnote providing any abbreviations used in the paper. Please indicate the number of words in the Abstract and in the text (not to include References) at the bottom of the page.This information should not be repeated in the manuscript text.

References
Please adhere strictly to the reference style of the journal. All references mentioned in the Reference section are cited in the text, and vice versa. The reference style is 'Embellished Vancouver' system with numbers in the text.
Text: Indicate references by superscript numbers in the text. The actual authors can be referred to, but the reference number(s) must always be given.
List: Number the references in the list in the order in which they appear in the text.
References to journals should contain names and initials of the author(s), article title, abbreviation of the name of the journal according to the List of Serial Title Word Abbreviations (International Serials Data System, 20, rue Bachaumont, 75002 Paris, France, ISBN 2-904938-02-8), year, volume number and page numbers.
References to books should also include the title (of series and volume), initials and names of the editor(s), publisher, place of publication, year.
Examples:
1. De Clercq E. Antiviral drugs: Current state of the art. J Clin Virol 2001;22,73-89.
2. Tartaglia J, Paoletti E. Live recombinant viral vaccines. In: van Regenmortel MHV and Neurath AR, editors. Immunochemistry of Viruses II. Amsterdam: Elsevier; 1990, p. 125-51.
3. Kaplan MH. Human herpesvirus-6 and HIV-1 infection. In: Ablashi DV, Krueger GRF, Salahuddin SZ, editors. Perspectives in Medical Virology, Vol. 4, Human herpesvirus-6. Amsterdam: Elsevier; 1992, p. 255-61.
Note shortened form for last page number. e.g., 125-51, and that for more than 6 authors the first 6 should be listed followed by 'et al.' For further details you are referred to "Uniform Requirements for Manuscripts submitted to Biomedical Journals" (J Am Med Assoc 1997;277:927-34), see also http://www.nlm.nih.gov/tsd/serials/terms_cond.html

Tables, Figures, and Legends When preparing tables, if you are using a table grid, use only one grid for each individual table and not a grid for each row. If no grid is used, use tabs, not spaces, to align columns. The electronic text should be prepared as done for conventional manuscripts. Do not import the figures into the text file but, instead, indicate their approximate locations directly in the electronic text and on the manuscript. See also the section on Preparation of electronic illustrations. Colour figures must be clearly marked as being intended for colour reproduction or to be reproduced in black-and-white. Reproduction of colour figures will incur a charge to the author; however if both colour and black-and-white figures (of the same figure) are supplied, it is possible to have the black-and-white image appear in print, and the colour image to appear on the online version at no extra cost. Please indicate if you would prefer this at the time of submission.

Supplementary material

Journal of Clinical Virology accepts electronic supplementary material to support and enhance your scientific research. Supplementary files offer the author additional possibilities to publish supporting applications, movies, animation sequences, high-resolution images, background datasets, sound clips. Please note additional text is not accepted. Supplementary files supplied will be published online alongside the electronic version of your article including ScienceDirect: http://www.sciencedirect.com In order to ensure that your submitted material is directly usable, please ensure that data is provided in one of our recommended file formats. Authors should submit the material in electronic format together with the article and supply a concise and descriptive caption for each file. For more detailed instructions please visit our artwork instruction pages at http://www.elsevier.com/artworkinstructions.

Language and language services Authors who require information about language editing and copyediting services pre- and post-submission please visit http://www.elsevier.com/languageediting or our customer support site at http://epsupport.elsevier.com for more information.

Ethics
Work on human beings that is submitted to the Journal should comply with the principles laid down in the Declaration of Helsinki; Recommendations guiding physicians in biomedical research involving human subjects. Adopted by the 18th World Medical Assembly, Helsinki, Finland, June 1964, amended by the 29th World Medical Assembly, Tokyo, Japan, October 1975, the 35th World Medical Assembly, Venice, Italy, October 1983, and the 41st World Medical Assembly, Hong Kong, September 1989. The manuscript should contain a statement that the work has been approved by the appropriate ethical committees related to the institution(s) in which it was performed and that subjects gave informed consent to the work (see declarations section above).

Studies on patients or volunteers require ethics committee approval and informed consent which should be documented in your paper. Patients have a right to privacy. Therefore identifying information, including patients¿ images, names, initials, or hospital numbers, should not be included in videos, recordings, written descriptions, photographs, and pedigrees unless the information is essential for scientific purposes and you have obtained written informed consent for publication in print and electronic form from the patient (or parent, guardian or next of kin where applicable). If such consent is made subject to any conditions, Elsevier must be made aware of all such conditions. Written consents must be provided to Elsevier on request.Even where consent has been given, identifying details should be omitted if they are not essential. If identifying characteristics are altered to protect anonymity, such as in genetic pedigrees, authors should provide assurance that alterations do not distort scientific meaning and editors should so note.If such consent has not been obtained, personal details of patients included in any part of the paper and in any supplementary materials (including all illustrations and videos) must be removed before submission.

Animal welfare
Authors using experimental animals must state that their care is in accordance with institutional guidelines. For animals subjected to invasive procedures, the anaesthetic, analgesic and tranquilizing agents used, as well as the amounts and frequency of administration, must be stated.

Proofs
Proofs will be sent to the authors to be carefully checked for printer's errors. Changes or additions to the edited manuscript cannot be allowed at this stage. Corrected proofs should be returned to the publisher within 2 days of receipt.

Offprints
The corresponding author, at no cost, will be provided with a PDF file of the article via e-mail. The PDF file is a watermarked version of the published article and includes a cover sheet with the journal cover image and a disclaimer outlining the terms and conditions of use. Additional paper offprints can be ordered by the authors. An order form with prices will be sent to the corresponding author.

Copyright
Upon acceptance of an article, authors will be asked to transfer copyright (for more information on copyright see www.elsevier.com/authors). This transfer will ensure the widest possible dissemination of information. A letter will be sent to the corresponding author confirming receipt of the manuscript. A form facilitating transfer of copyright will be provided.

If excerpts from other copyrighted works are included, the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has pre-printed forms for use by authors in these cases: contact ES Global Rights Department, P.O. Box 800, Oxford, OX5 1DX, UK; phone: (+44) 1865 843830, fax: (+44) 1865 853333, E-mail: permissions@elsevier.com.

Funding body agreements and policies
Elsevier has established agreements and developed policies to allow authors whose articles appear in journals published by Elsevier, to comply with potential manuscript archiving requirements as specified as conditions of their grant awards. To learn more about existing agreements and policies please visit http://www.elsevier.com/fundingbodies
Open Access
This journal offers authors two choices to publish their research;
1. Open Access
• Articles are freely available to both subscribers and the wider public with permitted reuse
• An Open Access publication fee is payable by authors or their research funder
2. Subscription
• Articles are made available to subscribers as well as developing countries and patient groups through our access programs (http://www.elsevier.com/access)
• No Open Access publication fee

All articles published Open Access will be immediately and permanently free for everyone to read and download. Permitted reuse is defined by your choice of one of the following Creative Commons user licenses:

Creative Commons Attribution-Non Commercial-ShareAlike (CC BY-NC-SA): for non-commercial purposes, lets others distribute and copy the article, to create extracts, abstracts and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text and data mine the article, as long as they credit the author(s), do not represent the author as endorsing their adaptation of the article, do not modify the article in such a way as to damage the author's honor or reputation, and license their new adaptations or creations under identical terms (CC BY NC SA).

Creative Commons Attribution-NonCommercial-NoDerivs (CC-BY-NC-ND): for non-commercial purposes, lets others distribute and copy the article, and to include in a collective work (such as an anthology), as long as they credit the author(s) and provided they do not alter or modify the article.

Creative Commons Attribution (CC-BY): available only for authors funded by organizations with which we have established an agreement with. For a full list please see www.elsevier.com/fundingbodies

Elsevier has established agreements with funding bodies. This ensures authors can comply with funding body Open Access requirements, including specific user licenses, such as CC-BY. Some authors may also be reimbursed for associated publication fees. www.elsevier.com/fundingbodies

To provide Open Access, this journal has a publication fee which needs to be met by the authors or their research funders for each article published Open Access. Your publication choice will have no effect on the peer review process or acceptance of submitted articles.

The Open Access publication fee for this journal is $USD 2,500, excluding taxes.

Learn more about Elsevier's pricing policy www.elsevier.com/openaccesspricing