Guide for Authors

  • All journal information and instructions compiled in one document (PDF) in just one mouse-click Author information pack

    INTRODUCTION
    • Types of paper
    • Contact details for submission
    BEFORE YOU BEGIN
    • Ethics in publishing
    • Editorial Policies and Practices
    • Conflict of interest
    • Submission declaration
    • Authorship
    • Changes to authorship
    • Copyright
    • Role of the funding source
    • Funding body agreements and policies
    • Open access
    • Language (usage and editing services)
    • Submission
    • Referees
    • Review Process
    PREPARATION
    • Manuscript Format
    • Use of word processing software
    • Article structure
    • Essential title page information
    • Abstract
    • Graphical abstract
    • Keywords
    • Abbreviations
    • Acknowledgements
    • Units
    • Math formulae
    • Footnotes
    • Artwork
    • Illustration services
    • Tables
    • References
    • Video data
    • AudioSlides
    • Supplementary data
    • Submission checklist
    • Acceptance and Online Only Publication
    AFTER ACCEPTANCE
    • Use of the Digital Object Identifier
    • Proofs
    • Offprints
    AUTHOR INQUIRIES



    Clinical Lymphoma, Myeloma & Leukemia is a peer-reviewed bimonthly journal that publishes original articles describing various aspects of clinical and translational research of lymphoma, myeloma and leukemia. Clinical Lymphoma, Myeloma &Leukemia is devoted to articles on detection, diagnosis, prevention, and treatment of lymphoma, myeloma, leukemia and related disorders including macroglobulinemia, amyloidosis, and plasma-cell dyscrasias. The main emphasis is on recent scientific developments in all areas related to lymphoma, myeloma and leukemia. Specific areas of interest include clinical research and mechanistic approaches; drug sensitivity and resistance; gene and antisense therapy; pathology, markers, and prognostic indicators; chemoprevention strategies; multimodality therapy; and integration of various approaches.

    Types of paper

    Reviews: Review articles collate, describe, and evaluate prior publications of important clinical subjects, accompanied by critical analysis leading to rational conclusions. These Reviews should contain very little, if any, original data from an author's own study; however, such data can be used to support the overall thesis of the article. We also accept targeted mini-reviews that cover specific topics or therapies.
    Mechanics: Reviews articles should contain a short abstract stating the goal of the review, an introduction, discussion, and conclusion. We recommend that Review articles contain 2000-10,000 words, ≤ 7 figures and/or tables, and 50-120 references.

    Perspectives: Perspectives are more focused than reviews and seek to review a topic from a particular view or opinion. Perspectives should review a particular field to identify outstanding issues and/or challenges and propose new hypotheses or directions. A Perspective may highlight emerging science, controversial opinions, or issues within the field and seek to address these controversies. They may be accepted from a single individual or a team.
    Mechanics: Perspectives should contain a short abstract stating the goal of the review, an introduction, discussion, and conclusion. We recommend that Perspective articles contain 2000-8000 words, ≤ 7 figures and/or tables, and 45-90 references.

    Original Studies: Original Studies articles present results of original clinical and/or translational (basic research with clinical applications) research. This article focuses on new data collected by the author(s) during the course of a clinical or preclinical trial, although other studies may be cited for support. The Original Study should contain the following sections: Title Page, Structured Abstract, Introduction, Patients (or Materials) and Methods, Results, Discussion, and Conclusion.
    Mechanics: Original Studies should contain a MicroAbstract and a structured abstract with the following sections: Background (or Purpose), Patients (or Materials) and Methods, Results, and Conclusion. Original Studies should also contain a short clinical practice points section after the conclusion of the manuscript. We recommend that Original Studies contain 2000-8000 words, ≤ 7 figures and/or tables, and 30-60 references.

    Case Reports: Case Reports of educational value may describe a single case or a small series of cases. Case Reports should draw attention to important clinical situations, unusual clinical phenomena, new treatment protocols, or new complications in a single patient or in a small number of patients. Case reports may also cover novel diagnostic imaging techniques, eg, MRI, CT, PET, SPECT. Modalities for diagnostic purposes, on outcome according to the pathologic grade or to monitor distant lesions, are of interest to the readership.
    Mechanics: Case Reports should contain the following sections: Title Page, Clinical Practice Points, Introduction, Discussion, and Conclusion. We recommend that Case Reports contain 500-1500 words, 1-2 figures and/or tables, and 15-30 references. Imaging articles dealing with individual cases contain 500-1500 and that case series contain 2000-3000 words, 3-5 figures and/or tables, and 30-45 references.

    Current Trial Reports: Current trials of educational value describe the rationale, criteria, treatment plan, and anticipated results of a planned or ongoing trial. The format for this article may follow a format similar to that of an Original Study (see above); however, because this type of article discusses an ongoing or planned trial, conclusive data regarding outcomes should not be included.
    Mechanics: Current Trial Reports should contain the following sections: Title Page, Structured Abstract, Introduction, Discussion, and Conclusion. We recommend that Current Trial Reports contain 500-1500 words, 1-2 figures and/or tables, and 5-15 references.

    Clinical Commentary: Clinical Commentaries focus on clinical topics that are novel or controversial and require rapid dissemination. These articles may also highlight treatment options, protocols, and/or novel case treatments. Authors who wish to submit an unsolicited Commentary should send a brief abstract to the Editor-in-Chief prior to submission in order to receive approval.
    Mechanics: Commentaries should contain the following sections: Title Page, Introduction, Discussion, and Conclusion. We recommend Commentaries contain 1000-2000 words, 1-2 figures and/or tables, and 15-30 references.

    Letters to the Editor: Letters to the Editor should focus on articles published within the journal during the last 12 months. These letters should be timely and seek to engage the authors of the original article in discussion. The authors of the original article will be asked to respond to a Letter to the Editor, commenting on their article. The Letter to the Editor and the Reply to the Letter to the Editor will be published together.
    Mechanics: We recommend that letters contain 500-1000 words, and they may contain 1-2 figures and/or tables and 5-15 references.

    Other Items: The journal also publishes highlights/reports of scientific meetings and book reviews. Please contact the editorial office for further information.

    Contact details for submission

    If you have questions regarding any of the requirements for submitting a manuscript to the Journal, please contact the editorial office at dav.allen@elsevier.com (864-610-0791).

    Ethics in publishing

    For information on Ethics in publishing and Ethical guidelines for journal publication see http://www.elsevier.com/publishingethics and http://www.elsevier.com/journal-authors/ethics.

    Editorial Policies and Practices

    Human Subject Studies: It is the responsibility of the authors to assure that all clinical investigations detailed in manuscripts submitted to the journal are conducted in accordance with the Declaration of Helsinki and to document that these studies have been approved by the appropriate institutional human research committee. Identifying information within written descriptions, photographs or pedigrees should not be published. If such information is included as essential scientific information, the authors must submit written consent of patient or guardian to publish such photographs in the print and electronic versions of the journal.

    Animal Studies: It is the responsibility of the authors to assure that their experimental procedures are in compliance with the guiding principles in the "Care and Use of Animals" (published each month in the Information for Authors of the American Journal of Physiology or available online at http://www.nap.edu/books/0309053773/html/) and to document that these studies were approved by the appropriate institutional animal care and oversight committee.

    Conflict of interest

    All authors must disclose any financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work. Examples of potential conflicts of interest include employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or other funding. See also http://www.elsevier.com/conflictsofinterest. Further information and an example of a Conflict of Interest form can be found at: http://help.elsevier.com/app/answers/detail/a_id/286/p/7923.

    Financial interests should be disclosed to the Editor-in-Chief in the cover letter and on a separate conflict of interest page in the manuscript.

    Submission declaration

    Submission of an article implies that the work described has not been published previously (except in the form of an abstract or as part of a published lecture or academic thesis or as an electronic preprint, see http://www.elsevier.com/postingpolicy), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere including electronically in the same form, in English or in any other language, without the written consent of the copyright-holder.

    Authorship

    All authors should have made substantial contributions to all of the following: (1) the conception and design of the study, or acquisition of data, or analysis and interpretation of data, (2) drafting the article or revising it critically for important intellectual content, (3) final approval of the version to be submitted.

    Changes to authorship

    This policy concerns the addition, deletion, or rearrangement of author names in the authorship of accepted manuscripts:
    Before the accepted manuscript is published in an online issue: Requests to add or remove an author, or to rearrange the author names, must be sent to the Journal Manager from the corresponding author of the accepted manuscript and must include: (a) the reason the name should be added or removed, or the author names rearranged and (b) written confirmation (e-mail, fax, letter) from all authors that they agree with the addition, removal or rearrangement. In the case of addition or removal of authors, this includes confirmation from the author being added or removed. Requests that are not sent by the corresponding author will be forwarded by the Journal Manager to the corresponding author, who must follow the procedure as described above. Note that: (1) Journal Managers will inform the Journal Editors of any such requests and (2) publication of the accepted manuscript in an online issue is suspended until authorship has been agreed.
    After the accepted manuscript is published in an online issue: Any requests to add, delete, or rearrange author names in an article published in an online issue will follow the same policies as noted above and result in a corrigendum.

    Copyright

    This journal offers authors a choice in publishing their research: Open access and Subscription.

    For subscription articles
    Upon acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement' (for more information on this and copyright, see http://www.elsevier.com/copyright). An e-mail will be sent to the corresponding author confirming receipt of the manuscript together with a 'Journal Publishing Agreement' form or a link to the online version of this agreement.
    Subscribers may reproduce tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution outside the institution and for all other derivative works, including compilations and translations (please consult http://www.elsevier.com/permissions). If excerpts from other copyrighted works are included, the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases: please consult http://www.elsevier.com/permissions.

    For open access articles
    Upon acceptance of an article, authors will be asked to complete an 'Exclusive License Agreement' (for more information see http://www.elsevier.com/OAauthoragreement). Permitted reuse of open access articles is determined by the author's choice of user license (see http://www.elsevier.com/openaccesslicenses).

    Retained author rights
    As an author you (or your employer or institution) retain certain rights. For more information on author rights for:
    Subscription articles please see http://www.elsevier.com/journal-authors/author-rights-and-responsibilities.
    Open access articles please see http://www.elsevier.com/OAauthoragreement.

    Role of the funding source

    You are requested to identify who provided financial support for the conduct of the research and/or preparation of the article and to briefly describe the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. If the funding source(s) had no such involvement then this should be stated.

    Funding body agreements and policies

    Elsevier has established agreements and developed policies to allow authors whose articles appear in journals published by Elsevier, to comply with potential manuscript archiving requirements as specified as conditions of their grant awards. To learn more about existing agreements and policies please visit http://www.elsevier.com/fundingbodies.

    Open access

    This journal offers authors a choice in publishing their research:

    Open access
    • Articles are freely available to both subscribers and the wider public with permitted reuse
    • An open access publication fee is payable by authors or their research funder
    Subscription
    • Articles are made available to subscribers as well as developing countries and patient groups through our access programs (http://www.elsevier.com/access)
    • No open access publication fee

    All articles published open access will be immediately and permanently free for everyone to read and download. Permitted reuse is defined by your choice of one of the following Creative Commons user licenses:
    Creative Commons Attribution-NonCommercial-ShareAlike (CC BY-NC-SA): for non-commercial purposes, lets others distribute and copy the article, to create extracts, abstracts and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text and data mine the article, as long as they credit the author(s), do not represent the author as endorsing their adaptation of the article, do not modify the article in such a way as to damage the author's honor or reputation, and license their new adaptations or creations under identical terms (CC BY-NC-SA).
    Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND): for non-commercial purposes, lets others distribute and copy the article, and to include in a collective work (such as an anthology), as long as they credit the author(s) and provided they do not alter or modify the article.

    Elsevier has established agreements with funding bodies, http://www.elsevier.com/fundingbodies. This ensures authors can comply with funding body open access requirements, including specific user licenses, such as CC BY. Some authors may also be reimbursed for associated publication fees. If you need to comply with your funding body policy, you can apply for the CC BY license after your manuscript is accepted for publication.

    To provide Open Access, this journal has a publication fee which needs to be met by the authors or their research funders for each article published open access.
    Your publication choice will have no effect on the peer review process or acceptance of submitted articles.

    The publication fee for this journal is $1,700, excluding taxes. Learn more about Elsevier's pricing policy: http://www.elsevier.com/openaccesspricing.

    Language (usage and editing services)

    Please write your text in good English (American or British usage is accepted, but not a mixture of these). Authors who feel their English language manuscript may require editing to eliminate possible grammatical or spelling errors and to conform to correct scientific English may wish to use the English Language Editing service available from Elsevier's WebShop (http://webshop.elsevier.com/languageediting/) or visit our customer support site (http://support.elsevier.com) for more information.

    Submission

    Submission to this journal proceeds totally online and you will be guided stepwise through the creation and uploading of your files. The system automatically converts source files to a single PDF file of the article, which is used in the peer-review process. Please note that even though manuscript source files are converted to PDF files at submission for the review process, these source files are needed for further processing after acceptance. All correspondence, including notification of the Editor's decision and requests for revision, takes place by e-mail removing the need for a paper trail.

    Submit your article
    Please submit your article via http://ees.elsevier.com/clml/.

    Full instructions for online submission are available on the Editorial Manager site. Upon receipt of a manuscript, an e-mail message will be sent to the corresponding author confirming receipt of the paper. If you do not receive this confirmation within 48 hours, contact the editorial office dav.allen@elsevier.com to confirm receipt.

    Referees

    Please submit the names and institutional e-mail addresses of several potential referees. For more details, visit our Support site. Note that the editor retains the sole right to decide whether or not the suggested reviewers are used.

    Review Process

    The Editorial team may triage a manuscript via initial review by the editorial staff, including the Editor and at least one Associate Editor, to ensure the paper meets certain criteria. Reasons for triage may include:

    • insufficient direct relevance to the scope of the Journal,
    • inadequate or unethical methodology,
    • inadequate statistical power or assessment,
    • insufficient innovation or contribution to the advancement of the field.
    All other manuscripts will undergo the full peer review process, being referred to an Associate Editor, who will identify reviewers with the expertise to review the paper. At each Associate Editor's discretion, any manuscript may be referred specifically for statistical review relating to the appropriateness or otherwise of statistics used, adjustment for multiple comparisons, sample size issues and the like. Manuscripts with inadequate or inappropriate statistics will not be accepted. Authors are encouraged to suggest names of appropriate reviewers (include phone/fax/address/e-mail for each reviewer suggested) and may also request that a specific reviewer not be used.

    Authors will receive a full response on their manuscript detailing any changes required by the Reviewers and Editorial team and the decision about the acceptance or otherwise of the manuscript. Only authors listed on the manuscript may receive information about a manuscript.

    Authors who wish to object to an unfavorable decision must do so within two months of notification of a decision. Please note all communications must be addressed to the editorial office via email dav.allen@elsevier.com. Any materials or communications sent to the Editor or Associate Editors will incur delays because they will be forwarded to the central Editorial Office for handling.

    Manuscript Format

    We wish to emphasize the importance of clarity and succinctness of the presentation of material:

    • Please respect the relevance of all material to the Introduction, Methods, Results and Discussion and avoid unnecessary repetition.
    • Do not repeat the results and conclusions in the Introduction.
    • Conclusions should NOT be stated throughout the Results section.
    • Results should not be restated throughout the Discussion section.
    • Avoid simply restating the Results in the Discussion rather than explaining how each result advances the overall conclusions of the study.
    • The final part of the Discussion should refer back to the rationale for the study and explain how the findings have advanced the area.

    We strongly recommend authors employ the format and guidelines detailed below.

    Abbreviations and Nomenclature: Abbreviations and nomenclature should follow the recommendations of the International Union of Pure and Applied Chemistry and the International Union of Biochemistry [see http://www.chem.qmul.ac.uk/iupac/jcbn/]. The International system of Units (SI units) is recommended. It is desirable to include appropriate conversion factors to aid the reader.

    Order
    Title Page, Conflict of Interest Page, MicroAbstract (Original Studies), Abstract, Introduction, Materials and Methods, Results, Discussion, Conclusion, Clinical Practice Points, Acknowledgments, References, Tables, Figures. (Number ALL pages consecutively)

    Use of word processing software

    It is important that the file be saved in the native format of the word processor used. The text should be in single-column format. Keep the layout of the text as simple as possible. Most formatting codes will be removed and replaced on processing the article. In particular, do not use the word processor's options to justify text or to hyphenate words. However, do use bold face, italics, subscripts, superscripts etc. When preparing tables, if you are using a table grid, use only one grid for each individual table and not a grid for each row. If no grid is used, use tabs, not spaces, to align columns. The electronic text should be prepared in a way very similar to that of conventional manuscripts (see also the Guide to Publishing with Elsevier: http://www.elsevier.com/guidepublication). Note that source files of figures, tables and text graphics will be required whether or not you embed your figures in the text. See also the section on Electronic artwork.
    To avoid unnecessary errors you are strongly advised to use the 'spell-check' and 'grammar-check' functions of your word processor.

    Article structure

    Subdivision - unnumbered sections
    Divide your article into clearly defined sections. Each subsection is given a brief heading. Each heading should appear on its own separate line. Subsections should be used as much as possible when cross-referencing text: refer to the subsection by heading as opposed to simply 'the text'.

    Introduction
    State the objectives of the work and provide an adequate background, avoiding a detailed literature survey or a summary of the results.

    Material and methods
    Provide sufficient detail to allow the work to be reproduced. Methods already published should be indicated by a reference: only relevant modifications should be described.

    Results
    Results should be clear and concise.

    Discussion
    This should explore the significance of the results of the work, not repeat them. A combined Results and Discussion section is often appropriate. Avoid extensive citations and discussion of published literature.

    Conclusions
    The main conclusions of the study may be presented in a short Conclusions section, which may stand alone or form a subsection of a Discussion or Results and Discussion section.

    Appendices
    If there is more than one appendix, they should be identified as A, B, etc. Formulae and equations in appendices should be given separate numbering: Eq. (A.1), Eq. (A.2), etc.; in a subsequent appendix, Eq. (B.1) and so on. Similarly for tables and figures: Table A.1; Fig. A.1, etc.

    Essential title page information

    Title. Concise and informative. Titles are often used in information-retrieval systems. Avoid abbreviations and formulae where possible.
    Author names and affiliations. Where the family name may be ambiguous (e.g., a double name), please indicate this clearly. Present the authors' affiliation addresses (where the actual work was done) below the names. Indicate all affiliations with a lower-case superscript letter immediately after the author's name and in front of the appropriate address. Provide the full postal address of each affiliation, including the country name and, if available, the e-mail address of each author.
    Corresponding author. Clearly indicate who will handle correspondence at all stages of refereeing and publication, also post-publication. Ensure that phone numbers (with country and area code) are provided in addition to the e-mail address and the complete postal address. Contact details must be kept up to date by the corresponding author.
    Present/permanent address. If an author has moved since the work described in the article was done, or was visiting at the time, a 'Present address' (or 'Permanent address') may be indicated as a footnote to that author's name. The address at which the author actually did the work must be retained as the main, affiliation address. Superscript Arabic numerals are used for such footnotes.

    Abstract

    The entire Abstract should not be more than 250 words. The abstract should be self-explanatory without reference to the text. Original Contributions should include a structured abstract with the following sections: Introduction/Background, Materials (or Patients) and Methods, Results, Conclusion.

    MicroAbstract (Original Studies)
    Each manuscript should start its abstract with a microabstract limited to 3-4 sentences (60 words). The microabstract is not included as part of the structured abstract and will be excerpted in the Table of Contents to each issue. It may also be used for wider circulation. It should describe the:

    • Area and reason for the study
    • Approach taken including sample size aspects
    • Overall result
    • General significance of the findings
    All information should be accessible to a non-expert audience.

    Clinical Practice Points (Original Studies, Case Reports)
    Authors should complete a short summary (250 words or less) detailing the clinical importance of the study. The summary should address the following questions:
    • What is already known about this subject?
    • What are the new findings?
    • How might it impact on clinical practice in the foreseeable future?

    Graphical abstract

    A Graphical abstract is optional and should summarize the contents of the article in a concise, pictorial form designed to capture the attention of a wide readership online. Authors must provide images that clearly represent the work described in the article. Graphical abstracts should be submitted as a separate file in the online submission system. Image size: Please provide an image with a minimum of 531 × 1328 pixels (h × w) or proportionally more. The image should be readable at a size of 5 × 13 cm using a regular screen resolution of 96 dpi. Preferred file types: TIFF, EPS, PDF or MS Office files. See http://www.elsevier.com/graphicalabstracts for examples.
    Authors can make use of Elsevier's Illustration and Enhancement service to ensure the best presentation of their images also in accordance with all technical requirements: Illustration Service.

    Keywords

    Five keywords should be listed at the bottom of the abstract page. Words used in the title of the article or journal title may not be used as keywords.

    Abbreviations

    Define abbreviations that are not standard in this field in a footnote to be placed on the first page of the article. Such abbreviations that are unavoidable in the abstract must be defined at their first mention there, as well as in the footnote. Ensure consistency of abbreviations throughout the article.

    Abbreviations should follow the recommendations of the International Union of Pure and Applied Chemistry and the International Union of Biochemistry [see http://www.chem.qmul.ac.uk/iupac/jcbn/].

    Acknowledgements

    Collate acknowledgements in a separate section at the end of the article before the references and do not, therefore, include them on the title page, as a footnote to the title or otherwise. List here those individuals who provided help during the research (e.g., providing language help, writing assistance or proof reading the article, etc.).

    Units

    Follow internationally accepted rules and conventions: use the international system of units (SI). If other units are mentioned, please give their equivalent in SI.

    Math formulae

    Present simple formulae in the line of normal text where possible and use the solidus (/) instead of a horizontal line for small fractional terms, e.g., X/Y. In principle, variables are to be presented in italics. Powers of e are often more conveniently denoted by exp. Number consecutively any equations that have to be displayed separately from the text (if referred to explicitly in the text).

    Footnotes

    Footnotes should be used sparingly. Number them consecutively throughout the article, using superscript Arabic numbers. Many wordprocessors build footnotes into the text, and this feature may be used. Should this not be the case, indicate the position of footnotes in the text and present the footnotes themselves separately at the end of the article. Do not include footnotes in the Reference list.
    Table footnotes
    Indicate each footnote in a table with a superscript lowercase letter.

    Artwork

    Electronic artwork
    General points
    • Make sure you use uniform lettering and sizing of your original artwork.
    • Embed the used fonts if the application provides that option.
    • Aim to use the following fonts in your illustrations: Arial, Courier, Times New Roman, Symbol, or use fonts that look similar.
    • Number the illustrations according to their sequence in the text.
    • Use a logical naming convention for your artwork files.
    • Provide captions to illustrations separately.
    • Size the illustrations close to the desired dimensions of the printed version.
    • Submit each illustration as a separate file.
    A detailed guide on electronic artwork is available on our website:
    http://www.elsevier.com/artworkinstructions
    You are urged to visit this site; some excerpts from the detailed information are given here.
    Formats
    If your electronic artwork is created in a Microsoft Office application (Word, PowerPoint, Excel) then please supply 'as is' in the native document format.
    Regardless of the application used other than Microsoft Office, when your electronic artwork is finalized, please 'Save as' or convert the images to one of the following formats (note the resolution requirements for line drawings, halftones, and line/halftone combinations given below):
    EPS (or PDF): Vector drawings, embed all used fonts.
    TIFF (or JPEG): Color or grayscale photographs (halftones), keep to a minimum of 300 dpi.
    TIFF (or JPEG): Bitmapped (pure black & white pixels) line drawings, keep to a minimum of 1000 dpi.
    TIFF (or JPEG): Combinations bitmapped line/half-tone (color or grayscale), keep to a minimum of 500 dpi.
    Please do not:
    • Supply files that are optimized for screen use (e.g., GIF, BMP, PICT, WPG); these typically have a low number of pixels and limited set of colors;
    • Supply files that are too low in resolution;
    • Submit graphics that are disproportionately large for the content.

    Color artwork
    Please make sure that artwork files are in an acceptable format (TIFF (or JPEG), EPS (or PDF) or MS Office files) and with the correct resolution. If, together with your accepted article, you submit usable color figures then Elsevier will ensure, at no additional charge, that these figures will appear in color on the Web (e.g., ScienceDirect and other sites) in addition to color reproduction in print. For further information on the preparation of electronic artwork, please see http://www.elsevier.com/artworkinstructions.

    Illustration services

    Elsevier's WebShop (http://webshop.elsevier.com/illustrationservices) offers Illustration Services to authors preparing to submit a manuscript but concerned about the quality of the images accompanying their article. Elsevier's expert illustrators can produce scientific, technical and medical-style images, as well as a full range of charts, tables and graphs. Image 'polishing' is also available, where our illustrators take your image(s) and improve them to a professional standard. Please visit the website to find out more.

    Please use small non-bold, non-italic capital letters and place them in Arial font when using figure headings/labels. Authors who would like to test their figures for publication quality should use Digital Expert: http://dx.sheridan.com/.

    Figure captions
    Ensure that each illustration has a caption. Supply captions separately, not attached to the figure. A caption should comprise a brief title (not on the figure itself) and a description of the illustration. Keep text in the illustrations themselves to a minimum but explain all symbols and abbreviations used.

    Tables

    Number tables consecutively in accordance with their appearance in the text. Place footnotes to tables below the table body and indicate them with superscript lowercase letters. Avoid vertical rules. Be sparing in the use of tables and ensure that the data presented in tables do not duplicate results described elsewhere in the article.

    References

    Citation in text
    Please ensure that every reference cited in the text is also present in the reference list (and vice versa). Any references cited in the abstract must be given in full. Unpublished results and personal communications are not recommended in the reference list, but may be mentioned in the text. If these references are included in the reference list they should follow the standard reference style of the journal and should include a substitution of the publication date with either 'Unpublished results' or 'Personal communication'. Citation of a reference as 'in press' implies that the item has been accepted for publication.

    Reference links
    Increased discoverability of research and high quality peer review are ensured by online links to the sources cited. In order to allow us to create links to abstracting and indexing services, such as Scopus, CrossRef and PubMed, please ensure that data provided in the references are correct. Please note that incorrect surnames, journal/book titles, publication year and pagination may prevent link creation. When copying references, please be careful as they may already contain errors. Use of the DOI is encouraged.

    Web references
    As a minimum, the full URL should be given and the date when the reference was last accessed. Any further information, if known (DOI, author names, dates, reference to a source publication, etc.), should also be given. Web references can be listed separately (e.g., after the reference list) under a different heading if desired, or can be included in the reference list.

    References in a special issue
    Please ensure that the words 'this issue' are added to any references in the list (and any citations in the text) to other articles in the same Special Issue.

    Reference style
    Text: Indicate references by (consecutive) superscript arabic numerals in the order in which they appear in the text. The numerals are to be used outside periods and commas, inside colons and semicolons. For further detail and examples you are referred to the AMA Manual of Style, A Guide for Authors and Editors, Tenth Edition, ISBN 0-978-0-19-517633-9 (see http://www.amanualofstyle.com).
    List: Number the references in the list in the order in which they appear in the text.
    Examples:
    Reference to a journal publication:
    1. Van der Geer J, Hanraads JAJ, Lupton RA. The art of writing a scientific article. J Sci Commun. 2010;163:51–59.
    Reference to a book:
    2. Strunk W Jr, White EB. The Elements of Style. 4th ed. New York, NY: Longman; 2000.
    Reference to a chapter in an edited book:
    3. Mettam GR, Adams LB. How to prepare an electronic version of your article. In: Jones BS, Smith RZ, eds. Introduction to the Electronic Age. New York, NY: E-Publishing Inc; 2009:281–304.

    Prescription information: Taxol (paclitaxel) Injection [prescribing information]: Princeton, NJ: Bristol-Myers Squibb; 2003.

    Erratum: Loehrer PJ, Sr., Einhorn LH, Elson PJ, et al. A randomized comparison of cisplatin alone or in combination with methotrexate, vinblastine, and doxorubicin in patients with metastatic urothelial carcinoma: a cooperative group study [published erratum appears in: J Clin Oncol 1993;11:384]. J Clin Oncol 1992; 10:1066-73.

    Non-English Language Translations: Zhang N, Gong K, Yang XY, et al. Expression of hypoxia-inducible factor-1-alpha, hypoxia-inducible factor-2alpha and vascular endothelial growth factor in sporadic clear cell renal cell renal cell carcinoma and their significance in the pathogenesis thereof. [in Chinese]. Zhonghua Yi Xue Za Zhi 2006; 86:1526-9.

    Journal abbreviations source
    Journal names should be abbreviated according to the List of Title Word Abbreviations: http://www.issn.org/services/online-services/access-to-the-ltwa/.

    Video data

    Elsevier accepts video material and animation sequences to support and enhance your scientific research. Authors who have video or animation files that they wish to submit with their article are strongly encouraged to include links to these within the body of the article. This can be done in the same way as a figure or table by referring to the video or animation content and noting in the body text where it should be placed. All submitted files should be properly labeled so that they directly relate to the video file's content. In order to ensure that your video or animation material is directly usable, please provide the files in one of our recommended file formats with a preferred maximum size of 50 MB. Video and animation files supplied will be published online in the electronic version of your article in Elsevier Web products, including ScienceDirect: http://www.sciencedirect.com. Please supply 'stills' with your files: you can choose any frame from the video or animation or make a separate image. These will be used instead of standard icons and will personalize the link to your video data. For more detailed instructions please visit our video instruction pages at http://www.elsevier.com/artworkinstructions. Note: since video and animation cannot be embedded in the print version of the journal, please provide text for both the electronic and the print version for the portions of the article that refer to this content.

    AudioSlides

    The journal encourages authors to create an AudioSlides presentation with their published article. AudioSlides are brief, webinar-style presentations that are shown next to the online article on ScienceDirect. This gives authors the opportunity to summarize their research in their own words and to help readers understand what the paper is about. More information and examples are available at http://www.elsevier.com/audioslides. Authors of this journal will automatically receive an invitation e-mail to create an AudioSlides presentation after acceptance of their paper.

    Supplementary data

    Elsevier accepts electronic supplementary material to support and enhance your scientific research. Supplementary files offer the author additional possibilities to publish supporting applications, high-resolution images, background datasets, sound clips and more. Supplementary files supplied will be published online alongside the electronic version of your article in Elsevier Web products, including ScienceDirect: http://www.sciencedirect.com. In order to ensure that your submitted material is directly usable, please provide the data in one of our recommended file formats. Authors should submit the material in electronic format together with the article and supply a concise and descriptive caption for each file. For more detailed instructions please visit our artwork instruction pages at http://www.elsevier.com/artworkinstructions.

    Submission checklist

    The following list will be useful during the final checking of an article prior to sending it to the journal for review. Please consult this Guide for Authors for further details of any item.
    Ensure that the following items are present:
    One author has been designated as the corresponding author with contact details:
    • E-mail address
    • Full postal address
    • Phone numbers
    All necessary files have been uploaded, and contain:
    • Keywords
    • All figure captions
    • All tables (including title, description, footnotes)
    Further considerations
    • Manuscript has been 'spell-checked' and 'grammar-checked'
    • References are in the correct format for this journal
    • All references mentioned in the Reference list are cited in the text, and vice versa
    • Permission has been obtained for use of copyrighted material from other sources (including the Web)
    • Color figures are clearly marked as being intended for color reproduction on the Web (free of charge) and in print, or to be reproduced in color on the Web (free of charge) and in black-and-white in print
    • If only color on the Web is required, black-and-white versions of the figures are also supplied for printing purposes
    For any further information please visit our customer support site at http://support.elsevier.com.

    Acceptance and Online Only Publication

    The editor reserves the right to schedule your manuscript for print or online only publication. All manuscripts will appear in a printed table of contents; however, some papers may only be available online due to print page restrictions.

    Use of the Digital Object Identifier

    The Digital Object Identifier (DOI) may be used to cite and link to electronic documents. The DOI consists of a unique alpha-numeric character string which is assigned to a document by the publisher upon the initial electronic publication. The assigned DOI never changes. Therefore, it is an ideal medium for citing a document, particularly 'Articles in press' because they have not yet received their full bibliographic information. Example of a correctly given DOI (in URL format; here an article in the journal Physics Letters B):
    http://dx.doi.org/10.1016/j.physletb.2010.09.059
    When you use a DOI to create links to documents on the web, the DOIs are guaranteed never to change.

    Proofs

    One set of page proofs (as PDF files) will be sent by e-mail to the corresponding author (if we do not have an e-mail address then paper proofs will be sent by post) or, a link will be provided in the e-mail so that authors can download the files themselves. Elsevier now provides authors with PDF proofs which can be annotated; for this you will need to download Adobe Reader version 9 (or higher) available free from http://get.adobe.com/reader. Instructions on how to annotate PDF files will accompany the proofs (also given online). The exact system requirements are given at the Adobe site: http://www.adobe.com/products/reader/tech-specs.html.
    If you do not wish to use the PDF annotations function, you may list the corrections (including replies to the Query Form) and return them to Elsevier in an e-mail. Please list your corrections quoting line number. If, for any reason, this is not possible, then mark the corrections and any other comments (including replies to the Query Form) on a printout of your proof and return by fax, or scan the pages and e-mail, or by post. Please use this proof only for checking the typesetting, editing, completeness and correctness of the text, tables and figures. Significant changes to the article as accepted for publication will only be considered at this stage with permission from the Editor. We will do everything possible to get your article published quickly and accurately – please let us have all your corrections within 48 hours. It is important to ensure that all corrections are sent back to us in one communication: please check carefully before replying, as inclusion of any subsequent corrections cannot be guaranteed. Proofreading is solely your responsibility. Note that Elsevier may proceed with the publication of your article if no response is received.

    Offprints

    The corresponding author, at no cost, will be provided with a PDF file of the article via e-mail (the PDF file is a watermarked version of the published article and includes a cover sheet with the journal cover image and a disclaimer outlining the terms and conditions of use). For an extra charge, paper offprints can be ordered via the offprint order form which is sent once the article is accepted for publication. Both corresponding and co-authors may order offprints at any time via Elsevier's WebShop (http://webshop.elsevier.com/myarticleservices/offprints). Authors requiring printed copies of multiple articles may use Elsevier WebShop's 'Create Your Own Book' service to collate multiple articles within a single cover (http://webshop.elsevier.com/myarticleservices/booklets).



    You can track your submitted article at http://help.elsevier.com/app/answers/detail/a_id/89/p/8045/p/8045. You can track your accepted article at http://www.elsevier.com/trackarticle. You are also welcome to contact Customer Support via http://support.elsevier.com.

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