Chemistry & Biology
Previously published by Current Trends. Now published by Cell Press
Chemistry & Biology publishes reports of novel investigations in all areas at the interface of chemistry and biology. Chemistry & Biology strongly encourages submission of articles in which chemical tools are used to provide unique insight into biological function and mechanism. Studies that illustrate the underlying chemistry of biological processes will also be viewed favorably. Other relevant studies of interest to chemists and biologists will also be considered. In general, to be considered suitable for publication in this journal, investigations that primarily have a genetic, computational, or theoretical focus must contain substantiating experimental data. All articles should not only be of significance to the immediate field but should also be of interest to our diverse readership from the broad chemical-biology community.
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Editors: Ronald Breaker , Michael Famulok , Peter Seeberger , Kevan Shokat , Wolfgang Wohlleben
Impact factor: 6.157
5 year impact factor: 6.097
Imprint: Cell Press
ISSN: 1074-5521
Most cited
Top 10 Cited (articles published in the last five years)
Extracted from Scopus (on Sat Jun 29)265 Blankman, J.L. | Simon, G.M. | Cravatt, B.F. A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol Chemistry and Biology, Volume 14, Issue 12, 2007-12-26, Pages 1347-1356 195 Clausell-Tormos, J. | Lieber, D. | Baret, J.-C. | El-Harrak, A. | Miller, O.J. | Frenz, L. | Blouwolff, J. | Humphry, K.J. | Köster, S. | Duan, H. | Holtze, C. | Weitz, D.A. | Griffiths, A.D. | Merten, C.A. Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms Chemistry and Biology, Volume 15, Issue 5, 2008-05-19, Pages 427-437 171 Gautier, A. | Juillerat, A. | Heinis, C. | Corrêa Jr., I.R. | Kindermann, M. | Beaufils, F. | Johnsson, K. An Engineered Protein Tag for Multiprotein Labeling in Living Cells Chemistry and Biology, Volume 15, Issue 2, 2008-02-22, Pages 128-136 169 Hong, S. | Leroueil, P.R. | Majoros, I.J. | Orr, B.G. | Baker Jr., J.R. | Banaszak Holl, M.M. The Binding Avidity of a Nanoparticle-Based Multivalent Targeted Drug Delivery Platform Chemistry and Biology, Volume 14, Issue 1, 2007-01-01, Pages 107-115 163 Pommier, Y. | Leo, E. | Zhang, H. | Marchand, C. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs Chemistry and Biology, Volume 17, Issue 5, 2010-07-07, Pages 421-433 124 Ahn, K. | Johnson, D.S. | Mileni, M. | Beidler, D. | Long, J.Z. | McKinney, M.K. | Weerapana, E. | Sadagopan, N. | Liimatta, M. | Smith, S.E. | Lazerwith, S. | Stiff, C. | Kamtekar, S. | Bhattacharya, K. | Zhang, Y. | Swaney, S. | Van Becelaere, K. | Stevens, R.C. | Cravatt, B.F. Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain Chemistry and Biology, Volume 16, Issue 4, 2009-04-24, Pages 411-420 115 Deacon, S.W. | Beeser, A. | Fukui, J.A. | Rennefahrt, U.E.E. | Myers, C. | Chernoff, J. | Peterson, J.R. An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase Chemistry and Biology, Volume 15, Issue 4, 2008-04-21, Pages 322-331 102 Schneider, C. | Pratt, D.A. | Porter, N.A. | Brash, A.R. Control of Oxygenation in Lipoxygenase and Cyclooxygenase Catalysis Chemistry and Biology, Volume 14, Issue 5, 2007-05-29, Pages 473-488 101 Cochrane, J.C. | Lipchock, S.V. | Strobel, S.A. Structural Investigation of the GlmS Ribozyme Bound to Its Catalytic Cofactor Chemistry and Biology, Volume 14, Issue 1, 2007-01-01, Pages 97-105 99 Diggle, S.P. | Matthijs, S. | Wright, V.J. | Fletcher, M.P. | Chhabra, S.R. | Lamont, I.L. | Kong, X. | Hider, R.C. | Cornelis, P. | Cámara, M. | Williams, P. The Pseudomonas aeruginosa 4-Quinolone Signal Molecules HHQ and PQS Play Multifunctional Roles in Quorum Sensing and Iron Entrapment Chemistry and Biology, Volume 14, Issue 1, 2007-01-01, Pages 87-96 - View all items
Most downloaded
Most Read Articles - counted by Article downloads on SciVerse ScienceDirect in the period 01 April 2002 to 31 May 2013
Sat Jun 291 Anna E Speers | Benjamin F Cravatt Profiling Enzyme Activities In Vivo Using Click Chemistry Methods Chemistry & Biology, Volume 11, Issue 4, April 2004, Pages 535-546 2 Zachary A. Knight | Kevan M. Shokat Features of Selective Kinase Inhibitors Chemistry & Biology, Volume 12, Issue 6, June 2005, Pages 621-637 3 Jochen Schust | Bianca Sperl | Angela Hollis | Thomas U. Mayer | Thorsten Berg Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization Chemistry & Biology, Volume 13, Issue 11, November 2006, Pages 1235-1242 4 Matthew P Coghlan | Ainsley A Culbert | Darren AE Cross | Stacey L Corcoran | John W Yates | Nigel J Pearce | Oliver L Rausch | Gregory J Murphy | Paul S Carter | Lynne Roxbee Cox | David Mills | Murray J Brown | David Haigh | Robert W Ward | David G Smith | Kenneth J Murray | Alastair D Reith | Julie C Holder Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription Chemistry & Biology, Volume 7, Issue 10, October 2000, Pages 793-803 5 Yves Pommier | Elisabetta Leo | HongLiang Zhang | Christophe Marchand DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs Chemistry & Biology, Volume 17, Issue 5, 28 May 2010, Pages 421-433 6 Laurent Meijer | Alexios-Leandros Skaltsounis | Prokopios Magiatis | Panagiotis Polychronopoulos | Marie Knockaert | Maryse Leost | Xiaozhou P. Ryan | Claudia Alin Vonica | Ali Brivanlou | Rana Dajani | Claudia Crovace | Cataldo Tarricone | Andrea Musacchio | S.Mark Roe | Laurence Pearl | Paul Greengard GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins Chemistry & Biology, Volume 10, Issue 12, December 2003, Pages 1255-1266 7 Amy C. Anderson The Process of Structure-Based Drug Design Chemistry & Biology, Volume 10, Issue 9, September 2003, Pages 787-797 8 Arnaud Gautier | Alexandre Juillerat | Christian Heinis | Ivan Reis Corrêa Jr. | Maik Kindermann | Florent Beaufils | Kai Johnsson An Engineered Protein Tag for Multiprotein Labeling in Living Cells Chemistry & Biology, Volume 15, Issue 2, 22 February 2008, Pages 128-136 9 Min-Jia Tan | Ji-Ming Ye | Nigel Turner | Cordula Hohnen-Behrens | Chang-Qiang Ke | Chun-Ping Tang | Tong Chen | Hans-Christoph Weiss | Ernst-Rudolf Gesing | Alex Rowland | David E. James | Yang Ye Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway Chemistry & Biology, Volume 15, Issue 3, 21 March 2008, Pages 263-273 10 Jenifer Clausell-Tormos | Diana Lieber | Jean-Christophe Baret | Abdeslam El-Harrak | Oliver J. Miller | Lucas Frenz | Joshua Blouwolff | Katherine J. Humphry | Sarah Köster | Honey Duan | Christian Holtze | David A. Weitz | Andrew D. Griffiths | Christoph A. Merten Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms Chemistry & Biology, Volume 15, Issue 5, 19 May 2008, Pages 427-437 - View all items
Recent articles
Sat Jun 291 Shilah A. Bonnett | Jonathan R. Whicher | Kancharla Papireddy | Galina Florova | Janet L. Smith | Kevin A. Reynolds Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene Chemistry & Biology, Volume 20, Issue 6, 20 June 2013, Pages 772-783 2 Tobias W. Giessen | Alexander M. von Tesmar | Mohamed A. Marahiel Insights into the Generation of Structural Diversity in a tRNA-Dependent Pathway for Highly Modified Bioactive Cyclic Dipeptides Chemistry & Biology, Volume 20, Issue 6, 20 June 2013, Pages 828-838 3 Sanjay B. Hari | Ethan A. Merritt | Dustin J. Maly Sequence Determinants of a Specific Inactive Protein Kinase Conformation Chemistry & Biology, Volume 20, Issue 6, 20 June 2013, Pages 806-815 4 Xiaofeng Cai | Roberta Teta | Christoph Kohlhaas | Max Crüsemann | Reiko Ueoka | Alfonso Mangoni | Michael F. Freeman | Jörn Piel Manipulation of Regulatory Genes Reveals Complexity and Fidelity in Hormaomycin Biosynthesis Chemistry & Biology, Volume 20, Issue 6, 20 June 2013, Pages 839-846 5 Hirokazu Kage | Martin F. Kreutzer | Barbara Wackler | Dirk Hoffmeister | Markus Nett An Iterative Type I Polyketide Synthase Initiates the Biosynthesis of the Antimycoplasma Agent Micacocidin Chemistry & Biology, Volume 20, Issue 6, 20 June 2013, Pages 764-771 6 Matthew A. Nix | Christopher B. Kaelin | Tina Ta | Allison Weis | Gregory J. Morton | Gregory S. Barsh | Glenn L. Millhauser Molecular and Functional Analysis of Human β-Defensin 3 Action at Melanocortin Receptors Chemistry & Biology, Volume 20, Issue 6, 20 June 2013, Pages 784-795 7 Taranjit S. Gujral | Ethan S. Karp | Marina Chan | Bryan H. Chang | Gavin MacBeath Family-wide Investigation of PDZ Domain-Mediated Protein-Protein Interactions Implicates β-Catenin in Maintaining the Integrity of Tight Junctions Chemistry & Biology, Volume 20, Issue 6, 20 June 2013, Pages 816-827 8 Hong-Min Ma | Qiang Zhou | Yu-Min Tang | Zhuan Zhang | Yong-Sheng Chen | Hai-Yan He | Hai-Xue Pan | Man-Cheng Tang | Ju-Fang Gao | Sheng-Yin Zhao | Yasuhiro Igarashi | Gong-Li Tang Unconventional Origin and Hybrid System for Construction of Pyrrolopyrrole Moiety in Kosinostatin Biosynthesis Chemistry & Biology, Volume 20, Issue 6, 20 June 2013, Pages 796-805 9 Lutz Kummer | Chia-Wen Hsu | Onur Dagliyan | Christopher MacNevin | Melanie Kaufholz | Bastian Zimmermann | Nikolay V. Dokholyan | Klaus M. Hahn | Andreas Plückthun Knowledge-Based Design of a Biosensor to Quantify Localized ERK Activation in Living Cells Chemistry & Biology, Volume 20, Issue 6, 20 June 2013, Pages 847-856 10 Alice McCarthy BGI Americas: Commercializing Next-Generation Sequencing Chemistry & Biology, Volume 20, Issue 6, 20 June 2013, Pages 743-744 - View all items
