Chemistry & Biology
Previously published by Current Trends. Now published by Cell Press
Chemistry & Biology publishes reports of novel investigations in all areas at the interface of chemistry and biology. Chemistry & Biology strongly encourages submission of articles in which chemical tools are used to provide unique insight into biological function and mechanism. Studies that illustrate the underlying chemistry of biological processes will also be viewed favorably. Other relevant studies of interest to chemists and biologists will also be considered. In general, to be considered suitable for publication in this journal, investigations that primarily have a genetic, computational, or theoretical focus must contain substantiating experimental data. All articles should not only be of significance to the immediate field but should also be of interest to our diverse readership from the broad chemical-biology community.
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Editors: Ronald Breaker , Michael Famulok , Peter Seeberger , Kevan Shokat , Wolfgang Wohlleben
Impact factor: 6.157Impact factor:
© Thomson Reuters Journal Citation Reports 2013
5 year impact factor: 6.097Five-Year Impact Factor:
To calculate the five year Impact Factor, citations are counted in 2013 to the previous five years and divided by the source items published in the previous five years.
© Journal Citation Reports 2013, Published by Thomson Reuters.
Imprint: Cell Press
Top 10 Cited (articles published in the last five years)
Extracted from Scopus (on Dec 02 )
215 Clausell-Tormos, J. | Lieber, D. | Baret, J.-C. | El-Harrak, A. | Miller, O.J. | Frenz, L. | Blouwolff, J. | Humphry, K.J. | Köster, S. | Duan, H. | Holtze, C. | Weitz, D.A. | Griffiths, A.D. | Merten, C.A. Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms Chemistry and Biology, Volume 15, Issue 5, 2008-05-19, Pages 427-437 201 Gautier, A. | Juillerat, A. | Heinis, C. | Corrêa Jr., I.R. | Kindermann, M. | Beaufils, F. | Johnsson, K. An Engineered Protein Tag for Multiprotein Labeling in Living Cells Chemistry and Biology, Volume 15, Issue 2, 2008-02-22, Pages 128-136 191 Pommier, Y. | Leo, E. | Zhang, H. | Marchand, C. DNA topoisomerases and their poisoning by anticancer and antibacterial drugs Chemistry and Biology, Volume 17, Issue 5, 2010-07-07, Pages 421-433 131 Deacon, S.W. | Beeser, A. | Fukui, J.A. | Rennefahrt, U.E.E. | Myers, C. | Chernoff, J. | Peterson, J.R. An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase Chemistry and Biology, Volume 15, Issue 4, 2008-04-21, Pages 322-331 130 Ahn, K. | Johnson, D.S. | Mileni, M. | Beidler, D. | Long, J.Z. | McKinney, M.K. | Weerapana, E. | Sadagopan, N. | Liimatta, M. | Smith, S.E. | Lazerwith, S. | Stiff, C. | Kamtekar, S. | Bhattacharya, K. | Zhang, Y. | Swaney, S. | Van Becelaere, K. | Stevens, R.C. | Cravatt, B.F. Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain Chemistry and Biology, Volume 16, Issue 4, 2009-04-24, Pages 411-420 102 Tan, M.-J. | Ye, J.-M. | Turner, N. | Hohnen-Behrens, C. | Ke, C.-Q. | Tang, C.-P. | Chen, T. | Weiss, H.-C. | Gesing, E.-R. | Rowland, A. | James, D.E. | Ye, Y. Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway Chemistry and Biology, Volume 15, Issue 3, 2008-03-21, Pages 263-273 94 Zaia, J. Mass Spectrometry and the Emerging Field of Glycomics Chemistry and Biology, Volume 15, Issue 9, 2008-09-22, Pages 881-892 90 Burnett, J.C. | Rossi, J.J. RNA-based therapeutics: Current progress and future prospects Chemistry and Biology, Volume 19, Issue 1, 2012-01-27, Pages 60-71 84 Long, J.Z. | Nomura, D.K. | Cravatt, B.F. Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism Chemistry and Biology, Volume 16, Issue 7, 2009-07-31, Pages 744-753 81 Schlosser, K. | Li, Y. Biologically Inspired Synthetic Enzymes Made from DNA Chemistry and Biology, Volume 16, Issue 3, 2009-03-27, Pages 311-322
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Most Read Articles - counted by Article downloads on SciVerse ScienceDirect in the period 01 December 2002 to 30 December 2013
Mon Dec 02
1 Yves Pommier | Elisabetta Leo | HongLiang Zhang | Christophe Marchand DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs Chemistry & Biology, Volume 17, Issue 5, 28 May 2010, Pages 421-433 2 Jenifer Clausell-Tormos | Diana Lieber | Jean-Christophe Baret | Abdeslam El-Harrak | Oliver J. Miller | Lucas Frenz | Joshua Blouwolff | Katherine J. Humphry | Sarah Köster | Honey Duan | Christian Holtze | David A. Weitz | Andrew D. Griffiths | Christoph A. Merten Droplet-Based Microfluidic Platforms for the Encapsulation and Screening of Mammalian Cells and Multicellular Organisms Chemistry & Biology, Volume 15, Issue 5, 19 May 2008, Pages 427-437 3 Min-Jia Tan | Ji-Ming Ye | Nigel Turner | Cordula Hohnen-Behrens | Chang-Qiang Ke | Chun-Ping Tang | Tong Chen | Hans-Christoph Weiss | Ernst-Rudolf Gesing | Alex Rowland | David E. James | Yang Ye Antidiabetic Activities of Triterpenoids Isolated from Bitter Melon Associated with Activation of the AMPK Pathway Chemistry & Biology, Volume 15, Issue 3, 21 March 2008, Pages 263-273 4 Arnaud Gautier | Alexandre Juillerat | Christian Heinis | Ivan Reis Corrêa Jr. | Maik Kindermann | Florent Beaufils | Kai Johnsson An Engineered Protein Tag for Multiprotein Labeling in Living Cells Chemistry & Biology, Volume 15, Issue 2, 22 February 2008, Pages 128-136 5 Jochen Schust | Bianca Sperl | Angela Hollis | Thomas U. Mayer | Thorsten Berg Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization Chemistry & Biology, Volume 13, Issue 11, November 2006, Pages 1235-1242 6 Amy C. Anderson The Process of Structure-Based Drug Design Chemistry & Biology, Volume 10, Issue 9, September 2003, Pages 787-797 7 Zachary A. Knight | Kevan M. Shokat Features of Selective Kinase Inhibitors Chemistry & Biology, Volume 12, Issue 6, June 2005, Pages 621-637 8 Anna E Speers | Benjamin F Cravatt Profiling Enzyme Activities In Vivo Using Click Chemistry Methods Chemistry & Biology, Volume 11, Issue 4, April 2004, Pages 535-546 9 Laurent Meijer | Alexios-Leandros Skaltsounis | Prokopios Magiatis | Panagiotis Polychronopoulos | Marie Knockaert | Maryse Leost | Xiaozhou P. Ryan | Claudia Alin Vonica | Ali Brivanlou | Rana Dajani | Claudia Crovace | Cataldo Tarricone | Andrea Musacchio | S.Mark Roe | Laurence Pearl | Paul Greengard GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins Chemistry & Biology, Volume 10, Issue 12, December 2003, Pages 1255-1266 10 Matthew P Coghlan | Ainsley A Culbert | Darren AE Cross | Stacey L Corcoran | John W Yates | Nigel J Pearce | Oliver L Rausch | Gregory J Murphy | Paul S Carter | Lynne Roxbee Cox | David Mills | Murray J Brown | David Haigh | Robert W Ward | David G Smith | Kenneth J Murray | Alastair D Reith | Julie C Holder Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription Chemistry & Biology, Volume 7, Issue 10, October 2000, Pages 793-803
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Mon Dec 02
1 Joanna F. McGouran | Selina R. Gaertner | Mikael Altun | Holger B. Kramer | Benedikt M. Kessler Deubiquitinating Enzyme Specificity for Ubiquitin Chain Topology Profiled by Di-Ubiquitin Activity Probes Chemistry & Biology, Available online 27 November 2013, 2 Yuan Yuan | Kate Hartland | Zarko Boskovic | Yikai Wang | Deepika Walpita | Philippe A. Lysy | Cheng Zhong | Damian W. Young | Young-kwon Kim | Nicola J. Tolliday | Etienne M. Sokal | Stuart L. Schreiber | Bridget K. Wagner A Small-Molecule Inducer of PDX1 Expression Identified by High-Throughput Screening Chemistry & Biology, Available online 27 November 2013, 3 Casey C. Fowler | Seiji Sugiman-Marangos | Murray S. Junop | Eric D. Brown | Yingfu Li Exploring Intermolecular Interactions of a Substrate Binding Protein Using a Riboswitch-Based Sensor Chemistry & Biology, Available online 27 November 2013, 4 Tomoshige Hiratsuka | Kento Koketsu | Atsushi Minami | Shunsuke Kaneko | Chiaki Yamazaki | Kenji Watanabe | Hiroki Oguri | Hideaki Oikawa Core Assembly Mechanism of Quinocarcin/SF-1739: Bimodular Complex Nonribosomal Peptide Synthetases for Sequential Mannich-type Reactions Chemistry & Biology, Available online 21 November 2013, 5 Ciorsdaidh A. Watts | Frances M. Richards | Andreas Bender | Peter J. Bond | Oliver Korb | Oliver Kern | Michelle Riddick | Paul Owen | Rebecca M. Myers | Jordan Raff | Fanni Gergely | Duncan I. Jodrell | Steven V. Ley Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes Chemistry & Biology, Volume 20, Issue 11, 21 November 2013, Pages 1399-1410 6 In This Issue Chemistry & Biology, Volume 20, Issue 11, 21 November 2013, Pages v-vi 7 Christina J. Matheny | Michael C. Wei | Michael C. Bassik | Alicia J. Donnelly | Martin Kampmann | Masayuki Iwasaki | Obdulio Piloto | David E. Solow-Cordero | Donna M. Bouley | Rachel Rau | Patrick Brown | Michael T. McManus | Jonathan S. Weissman | Michael L. Cleary Next-Generation NAMPT Inhibitors Identified by Sequential High-Throughput Phenotypic Chemical and Functional Genomic Screens Chemistry & Biology, Volume 20, Issue 11, 21 November 2013, Pages 1352-1363 8 Simon P. Wisnovsky | Justin J. Wilson | Robert J. Radford | Mark P. Pereira | Maria R. Chan | Rebecca R. Laposa | Stephen J. Lippard | Shana O. Kelley Targeting Mitochondrial DNA with a Platinum-Based Anticancer Agent Chemistry & Biology, Volume 20, Issue 11, 21 November 2013, Pages 1323-1328 9 Giang Thi Tuyet Nguyen | Melanie Gertz | Clemens Steegborn Crystal Structures of Sirt3 Complexes with 4'-Bromo-Resveratrol Reveal Binding Sites and Inhibition Mechanism Chemistry & Biology, Volume 20, Issue 11, 21 November 2013, Pages 1375-1385 10 Szu-Chieh Mei | Charles Brenner NAD as a Genotype-Specific Drug Target Chemistry & Biology, Volume 20, Issue 11, 21 November 2013, Pages 1307-1308
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