CVP Instructions for Authors

Cardiovascular Pathology is the official Journal of the Society for Cardiovascular Pathology, which appoints the Editor and determines Editorial policy. The Journal publishes peer-reviewed articles on all aspects of cardiovascular disease, but with a particular focus on the pathology and pathogenesis of these entities. Authors are invited to submit original research articles. Brief communications, case reports with significant new findings, as well as letters to the Editors will be considered. Review articles may be invited or unsolicited submissions.

Aims of the Journal
Decisions regarding acceptance for publication of submitted articles will be made by the Editors. Submitted articles will be peer reviewed. Papers submitted for publication should not be under publication or review by any other journal. An assignment of copyright transfer must accompany the final version of the accepted manuscript submitted to Cardiovascular Pathology. No part of the published materials may be reproduced elsewhere without prior written permission from the publisher.

Ethics in publishing
For information on Ethics in publishing and Ethical guidelines for journal publication see http://www.elsevier.com/publishingethics and http://www.elsevier.com/ethicalguidelines.

Policy and ethics
The work described in your article must have been carried out in accordance with The Code of Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving humans http://www.wma.net/en/30publications/10policies/b3/index.html; EU Directive 2010/63/EU for animal experiments http://ec.europa.eu/environment/chemicals/lab_animals/legislation_en.htm; Uniform Requirements for manuscripts submitted to Biomedical journals http://www.icmje.org. This must be stated at an appropriate point in the article.

Conflict of interest
All authors must disclose any financial and personal relationships with other people or organizations that could inappropriately influence (bias) their work. Examples of potential conflicts of interest include employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations, and grants or other funding. See also http://www.elsevier.com/conflictsofinterest.

Submission declaration
Submission of an article implies that the work described has not been published previously (except in the form of an abstract or as part of a published lecture or academic thesis or as an electronic preprint, see http://www.elsevier.com/postingpolicy), that it is not under consideration for publication elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was carried out, and that, if accepted, it will not be published elsewhere including electronically in the same form, in English or in any other language, without the written consent of the copyright-holder.

Authorship
All authors should have made substantial contributions to all of the following: (1) the conception and design of the study, or acquisition of data, or analysis and interpretation of data, (2) drafting the article or revising it critically for important intellectual content, (3) final approval of the version to be submitted.

Changes to authorship
This policy concerns the addition, deletion, or rearrangement of author names in the authorship of accepted manuscripts:

Before the accepted manuscript is published in an online issue: Requests to add or remove an author, or to rearrange the author names, must be sent to the Journal Manager from the corresponding author of the accepted manuscript and must include: (a) the reason the name should be added or removed, or the author names rearranged and (b) written confirmation (e-mail, fax, letter) from all authors that they agree with the addition, removal or rearrangement. In the case of addition or removal of authors, this includes confirmation from the author being added or removed. Requests that are not sent by the corresponding author will be forwarded by the Journal Manager to the corresponding author, who must follow the procedure as described above. Note that: (1) Journal Managers will inform the Journal Editors of any such requests and (2) publication of the accepted manuscript in an online issue is suspended until authorship has been agreed.

After the accepted manuscript is published in an online issue: Requests to add, delete, or rearrange author names in an article published in an online issue will follow the same policies as noted above and result in a corrigendum.

Copyright
Upon acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement' (for more information on this and copyright see http://www.elsevier.com/copyright). Acceptance of the agreement will ensure the widest possible dissemination of information. An e-mail will be sent to the corresponding author confirming receipt of the manuscript together with a 'Journal Publishing Agreement' form or a link to the online version of this agreement.
Subscribers may reproduce tables of contents or prepare lists of articles including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution outside the institution and for all other derivative works, including compilations and translations (please consult http://www.elsevier.com/permissions). If excerpts from other copyrighted works are included, the author(s) must obtain written permission from the copyright owners and credit the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases: please consult http://www.elsevier.com/permissions.

Unpublished materialMaterial in unpublished letters and manuscripts is also protected and must not be published unless permission has been obtained.

Retained author rights
As an author you (or your employer or institution) retain certain rights; for details you are referred to: http://www.elsevier.com/authorsrights.

Role of the funding source
You are requested to identify who provided financial support for the conduct of the research and/or preparation of the article and to briefly describe the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication. If the funding source(s) had no such involvement then this should be stated. Please see http://www.elsevier.com/funding.

Funding body agreements and policies
Elsevier has established agreements and developed policies to allow authors whose articles appear in journals published by Elsevier, to comply with potential manuscript archiving requirements as specified as conditions of their grant awards. To learn more about existing agreements and policies please visit http://www.elsevier.com/fundingbodies.

Submission of Manuscripts
Manuscripts must be written in English. All manuscripts must be submitted through the Cardiovascular Pathology online submission and review web site (http://ees.elsevier.com/cvp/ ). All authors are requested to submit the text, tables and artwork in electronic form (not as a PDF) through the Web site. Authors should also state that the manuscript or parts of it have not been and will not be submitted elsewhere for publication, while in the review process for Cardiovascular Pathology.

The web site guides authors step-by-step, through the creation and uploading of various files. Authors may send queries concerning the submission process, manuscript status or journal procedures to the Editorial Office.

Submitted items must include a cover letter, the manuscript (including the title page, abstract, manuscript text, references and table/figure legends), Tables and Figures. The preferred order of files is as follows: cover letter, response to reviewer's comments (revised manuscripts only), manuscript file(s), Figure(s). Files should be labeled with appropriate and descriptive file name (ex.smithtext.doc, Fig1.eps, Table3.doc, etc). Upload text, tables and graphics as separate files. Do not import figures or tables into the text document and do not upload your text as a PDF. Complete instructions for electronic artwork submission may be found at www.elsevier.com/authors. Authors who are unable to provide an electronic version or have other circumstances that prevent online submission must contact the Editorial Office prior to submission to discuss alternate options. The Publishers and the Editors regret that they are not able to consider submissions that do not follow these procedures.

The revised manuscript should also be accompanied by a unique file (separate from the covering letter) with the response to the reviewer's comments listed, item number by item number.

Once the submission files are uploaded, the system automatically generates electronic (PDF) proof, which is then used for reviewing. All correspondence including the Editor's decision and request for revisions will be by e-mail only.

General Guidelines: Manuscripts should be prepared in the style of the journal and should conform to the guidelines in "Uniform requirements for manuscripts submitted to biomedical journals, fifth edition. These requirements were prepared by the International Committee of Medical Journal Editors and published in the New England Journal of Medicine, 1997;336: 309-15.

Conflict of Interest Guidelines: Sources of funding should be acknowledged and all authors must disclose any commercial association or other arrangement (financial compensation, potential to profit, consultancy, stock ownership, honor, patent-licensing arrangements, etc) that might pose or imply a conflict of interest in connection with the submitted paper. Some or all such information will be available to the reviewer and at the discretion of the Editor, will be published in a footnote to the article.

Preparation of Manuscripts: In the case of all original articles, the following materials must be submitted. The manuscript should be arranged as Title Page, Summary, Structured Abstract with Key Words, Introduction, Methods, Results, Discussion, Acknowledgements, References, Figure Legends, Tables and Figures. Pages must be numbered consecutively beginning with the Title Page as number 1. The last name of the first author must be typed at the top of each page. All authors listed on the title page should have full first name and degrees. The manuscript should be double-spaced on pages (size 22 x 28 cm/8.5 x 11 inches). A 3.0 cm (1.2 inch) margin all around is advised.

Upon receipt, the Editorial Office, through the EES system, will send an acknowledgement that the manuscript has been received. Each manuscript will be given a Manuscript number. All future correspondence must refer to the manuscript number.

Title Page: The Title page must include a concise title: names of all authors; department, and institution address where the research was conducted; number of text pages including tables and figures; a short running title (60 characters or less): name, address, telephone number, fax number and email address of corresponding author.

Structured Abstract: The structured abstract should be no more than 250 words and should be on a separate sheet. It must be divided into sections as: Background or Introduction, Methods, Results and Conclusions.

Summary: The mini summary should be 60 words long or less and will be printed with the title on the contents page.

Key Words: Two to six key words should be listed for indexing of the article. These must be selected appropriately.

Text: Abbreviations must be defined at first mention in the text and should follow the form recommended in the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals". Headings and subheadings should be provided in the different sections of the article, such as methods, results, discussion, etc.

Experimental Animals: If experimental animals have been used in the study, a statement must be provided in the text (Methods Section) to indicate that all procedures were in accordance with accepted institutional policies.

Human Subjects: In the case of human subjects, the text must indicate that the appropriate institutional and ethics committee approval had been obtained.

Acknowledgments: Individuals who contributed significantly to the preparation of the manuscript may be acknowledged in this section. The covering letter to the Editor-in-Chief should indicate that those named have granted permission.

References in Text: Identify references in the text by using Arabic numerals (on the line). Type the reference list on separate pages.

Figure Legends: These must be typed on separate sheets, double spaced, separate from the text with Figure numbers corresponding to the order in which Figures appeared within the text. All abbreviations listed in the figures should be identified in alphabetical order at the end of each Legend. Sufficient information should be provided for the Figures, so that they may be appropriately interpreted without reference to the text. Material that is reproduced from previously published figures should be accompanied by written permission from the publisher. The source of the Figure should be cited in the Legend.

Tables: These must be typed double-spaced on separate sheets with the Table Number above the table and the table title immediately after the table number. Explanatory notes should be appended as footnotes. Number tables consecutively in accordance with their appearance in the text. Place footnotes to tables below the table body and indicate them with superscript lowercase letters. Avoid vertical rules. Be sparing in the use of tables and ensure that the data presented in tables do not duplicate results described elsewhere in the article. Table numbers should be Arabic numerals and correspond to the order of appearance of the tables in the text. Tables must be self-explanatory and authors must insure that the data is not duplicated in the text. Written permission from the publisher must accompany the articles when the table is reproduced from previously published data.

Nomenclature and units: Proprietary names of drugs, instruments etc. should be indicated by the use of initial capital letters. All measurements should be expressed in SI or SI-derived units.

Artwork and Figures

Electronic artwork

General points

• Make sure you use uniform lettering and sizing of your original artwork.
• Embed the used fonts if the application provides that option.
• Aim to use the following fonts in your illustrations: Arial, Courier, Times New Roman, Symbol, or use fonts that look similar.
• Number the illustrations according to their sequence in the text.
• Use a logical naming convention for your artwork files.
• Provide captions to illustrations separately.
• Size the illustrations close to the desired dimensions of the printed version.
• Submit each illustration as a separate file.

A detailed guide on electronic artwork is available on our website: http://www.elsevier.com/artworkinstructions
You are urged to visit this site; some excerpts from the detailed information are given here.

Formats
If your electronic artwork is created in a Microsoft Office application (Word, PowerPoint, Excel) then please supply 'as is' in the native document format. Regardless of the application used other than Microsoft Office, when your electronic artwork is finalized, please 'Save as' or convert the images to one of the following formats (note the resolution requirements for line drawings, halftones, and line/halftone combinations given below):
EPS (or PDF): Vector drawings, embed all used fonts. TIFF (or JPEG): Color or grayscale photographs (halftones), keep to a minimum of 300 dpi. TIFF (or JPEG): Bitmapped (pure black & white pixels) line drawings, keep to a minimum of 1000 dpi. TIFF (or JPEG): Combinations bitmapped line/half-tone (color or grayscale), keep to a minimum of 500 dpi.

Please do not:

• Supply files that are optimized for screen use (e.g., GIF, BMP, PICT, WPG); these typically have a low number of pixels and limited set of colors;
• Supply files that are too low in resolution;
• Submit graphics that are disproportionately large for the content.

Where illustrations must include recognizable individuals, living or dead and of whatever age, great care must be taken to ensure that consent for publication has been given. It is the authors' responsibility to obtain written permission to reproduce borrowed material (illustrations and tables) from the original publishers and authors.

Color artwork
Please make sure that artwork files are in an acceptable format (TIFF (or JPEG), EPS (or PDF), or MS Office files) and with the correct resolution. If, together with your accepted article, you submit usable color figures then Elsevier will ensure, at no additional charge, that these figures will appear in color on the Web (e.g., ScienceDirect and other sites) regardless of whether or not these illustrations are reproduced in color in the printed version. For color reproduction in print, you will receive information regarding the costs from Elsevier after receipt of your accepted article. Please indicate your preference for color: in print or on the Web only. For further information on the preparation of electronic artwork, please see http://www.elsevier.com/artworkinstructions.

Please note: Because of technical complications which can arise by converting color figures to 'gray scale' (for the printed version should you not opt for color in print) please submit in addition usable black and white versions of all the color illustrations.

Color versus black and white figures
Figures must be limited to those essential to the paper There is no charge for black and while illustrations. Color art in print reproduction costs will be charged to the author (USD 650 for the first color figure and USD 100 for each additional figure in the article). Color artwork supplied with your article will appear in color on the web-at no charge. Please note: Because of technical complications which can arise by converting color figures to 'gray scale' (for the printed version should you not opt for color in print) please submit in addition usable black and white versions of all the color illustrations. If authors do not intend to incur the expense for publication of color figures in the printed journal, then the authors are urged to upload both high quality black and white as well as color versions of the figures on submission of the manuscript.

Web references: Refrain from using online references if possible. When referring to internet sources, for example Wikipedia, please state so clearly, and indicate if this information can be checked and on which date you visited this online source.

References: References should begin on a separate page, be double spaced, and be numbered in the order of citation in the text. References must include complete author's citations (use of "et al" is accepted only if there are more than six authors in the listing).

Discoverability of research and high quality peer review are ensured by online links to the sources cited. In order to allow us to create links within ScienceDirect and to abstracting and indexing services, such as Scopus, CrossRef or PubMed, please ensure that data provided in the references are correct. Please note that incorrect surnames, journal/book titles, publication year and pagination may prevent the link creation. When copying references, please be careful as they may already contain an error.

There are no strict requirements on reference formatting at submission. References can be in any style or format as long as the style is consistent. Author(s) name(s), journal title/book title, chapter title/article title, year of publication, volume and issue/book chapter and the pagination must be present. The reference style used by the journal is Vancouver numbered, and this style will be applied to the accepted article by Elsevier at the proof stage. Note that incorrect or missing data will be highlighted at proof stage for the author to correct. Examples of the Vancouver numbered format are as follows:

Journal Articles: Marino B, Sigilio MC. Congenital heart disease and genetic syndromes: Specific correlation between cardiac phenotype and genotype. Cardiovasc Pathol 2000;9:303-16.

Books: Reimer KA, Jennings RB. Myocardial ischemia, hypoxia, and infarction. In: Fozzard HA, Haber E, Jennings RB, Katz AM, Morgan HE, editors. The Heart and Cardiovascular System: Scientific Foundations, 2nd ed., vol. II. New York: Raven Press, 1992, p. 1875-973.

In Press: This is to be used only for papers accepted for publication. Cite these articles as for other articles with (in press) in place of volume and page numbers. These papers also can be sited as: year date [Epub ahead of print]. Example: Segura AM, Frazier OH, Buja LM. Fibrosis and heart failure. Heart Fail Rev 2012 Nov 4 [Epub ahead of print]

Note shortened form for last page number. e.g., 51-9, and that for more than 6 authors the first 6 should be listed followed by 'et al.' For further details you are referred to 'Uniform Requirements for Manuscripts submitted to Biomedical Journals' (J Am Med Assoc 1997;277:927-34) (see also http://www.nlm.nih.gov/bsd/uniform_requirements.html).

Video data
Elsevier accepts video material and animation sequences to support and enhance your scientific research. Authors who have video or animation files that they wish to submit with their article are strongly encouraged to include links to these within the body of the article. This can be done in the same way as a figure or table by referring to the video or animation content and noting in the body text where it should be placed. All submitted files should be properly labeled so that they directly relate to the video file's content. In order to ensure that your video or animation material is directly usable, please provide the files in one of our recommended file formats with a preferred maximum size of 50 MB. Video and animation files supplied will be published online in the electronic version of your article in Elsevier Web products, including ScienceDirect: http://www.sciencedirect.com. Please supply 'stills' with your files: you can choose any frame from the video or animation or make a separate image. These will be used instead of standard icons and will personalize the link to your video data. For more detailed instructions please visit our video instruction pages at http://www.elsevier.com/artworkinstructions. Note: since video and animation cannot be embedded in the print version of the journal, please provide text for both the electronic and the print version for the portions of the article that refer to this content.

Types of Manuscripts

Brief Communications: Limit 2000 words, 5 references, and one Figure or Table. Materials and methods may be condensed but of sufficient detail to permit evaluation by reviewers and reproduction by other workers.

Full Manuscripts: These include original articles and reviews. The target length is 3000 words (12 double spaced pages). Longer submissions will be considered.

Case Reports: Only well worked up case reports about new or interesting entities with a review of the literature will be considered. References - maximum of five.

Images in Cardiovascular Pathology: Text should be no more than 500 words with a maximum of five references.

Innovative CV Pathology, Pathobiology, Interventions and Technologies: These review articles will have the following characteristics: one article per issue or less (4-6 per year), up to 2000 words text + up to approximately 25 references, and 5 major categories and many choices within each; for example:

1. Prosthetics (e.g., endovascular stents, vascular grafts, stent grafts, cardiac assist devices/artificial hearts, valves, cardiovascular biomaterials). Contributions on prosthetics have at least 3 sections: description of device, pathophysiologic principles, sequelae/complications.
2. Interventions/Surgery (e.g., PTCA, valve repair, transmyocardial laser revascularization, arrhythmia ablation, xenotransplantation, minimally-invasive surgery). Contributions on interventions/procedures have at least 3 sections: description of technology, pathophysiologic principles, sequelae/complications.
3. Pharmacologic/genetic/biologic therapeutics (e.g., pharmacogenetics, antiangiogenesis, statins, intracoronary radiation, prevention of restenosis).
4. Molecular diagnostics, genomics, proteomics, biomarkers and computational biology.
5. Other, including mechanisms of disease, novel/evolving concepts (e.g., computerized flow dynamics, blood-surface interaction, prosthetic device infection, tissue remodeling, stem cells and other biotechnology approaches, myocardial regeneration, tissue engineering, drug delivery systems, quantitation of myocardial cell size, early diagnosis of MI, assessment of cell phenotype, characterization of extracellular matrix, imaging, methods of analysis).

Letters to the Editor: These should be limited to 1500 words, 5 references and one Figure or Table.

Proofs
The corresponding author will receive proofs from the Printer via e-mail in PDF format. The author must check the proofs carefully, mark any printer's errors and answer all queries. Changes must be kept to a minimum. Proofs must be returned within 48 hours to avoid any further delays in publication.

AudioSlides
The journal encourages authors to create an AudioSlides presentation with their published article. AudioSlides are brief, webinar-style presentations that are shown next to the online article on ScienceDirect. This gives authors the opportunity to summarize their research in their own words and to help readers understand what the paper is about. More information and examples are available at http://www.elsevier.com/audioslides. Authors of this journal will automatically receive an invitation e-mail to create an AudioSlides presentation after acceptance of their paper.

Open access
This journal offers authors two choices to publish their research;
1. Open Access

• Articles are freely available to both subscribers and the wider public with permitted reuse
• An Open Access publication fee is payable by authors or their research funder

• Articles are made available to subscribers as well as developing countries and patient groups through our access programs (http://www.elsevier.com/access)
• No Open Access publication fee

All articles published Open Access will be immediately and permanently free for everyone to read and download. Permitted reuse is defined by your choice of one of the following Creative Commons user licenses:

Creative Commons Attribution-Non Commercial-ShareAlike (CC BY-NC-SA): for non-commercial purposes, lets others distribute and copy the article, to create extracts, abstracts and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text and data mine the article, as long as they credit the author(s), do not represent the author as endorsing their adaptation of the article, do not modify the article in such a way as to damage the author's honor or reputation, and license their new adaptations or creations under identical terms (CC BY NC SA).

Creative Commons Attribution-NonCommercial-NoDerivs (CC-BY-NC-ND): for non-commercial purposes, lets others distribute and copy the article, and to include in a collective work (such as an anthology), as long as they credit the author(s) and provided they do not alter or modify the article.

Creative Commons Attribution (CC-BY): available only for authors funded by organizations with which we have established an agreement with. For a full list please see www.elsevier.com/fundingbodies.

Elsevier has established agreements with funding bodies. This ensures authors can comply with funding body Open Access requirements, including specific user licenses, such as CC-BY. Some authors may also be reimbursed for associated publication fees. www.elsevier.com/fundingbodies

To provide Open Access, this journal has a publication fee which needs to be met by the authors or their research funders for each article published Open Access. Your publication choice will have no effect on the peer review process or acceptance of submitted articles.

The Open Access publication fee for this journal is US $3,000, excluding taxes.

Learn more about Elsevier's pricing policy
www.elsevier.com/openaccesspricing

Your publication choice will have no effect on the peer review process or acceptance of submitted articles.

Updated May 2013