Ulrich Brandt is Professor of Biochemistry and Molecular Bioenergetics at the Centre for Biological Chemistry in Frankfurt am Main. He graduated in Biochemistry from the Eberhard-Karls University in TÃ¼bingen and obtained his PhD from the Ludwig-Maximilians University in Munich for his research on specific inhibitors of the mitochondrial cytochrome bc1 complex and functional aspects of cytochrome c oxidase.
Between 1991 and 1993, Dr. Brandt was a Feodor-Lynen fellow of the Humboldt Foundation in the laboratory of Bernard L. Trumpower at the Dartmouth Medical School, New Hampshire, where he started working in the field of yeast genetics. Late in 1993 He returned to Germany to the Johann-Wolfgang-Goethe University in Frankfurt am Main, where he became a Docent in 1994 and a Professor of Biochemistry in 1996. Since 1997 Dr. Brandt is Vice-Director of the Centre of Biological Chemistry at the Medical Faculty, Goethe-University. In the same year he was elected Secretary General of the German Society for Biochemistry and Molecular Biology. He is also founding member of the Cluster of Excellence "Macromolecular Complexes" of the Goethe-University.
His research interest focuses on the structure and function of respiratory chain complexes. Dr. Brandt's group has established the strictly aerobic yeast Yarrowia lipolytica as a powerful model to study mitochondrial complex I. Taking advantage of versatile yeast genetics, a broad range of biochemical and biophysical approaches is applied. Current projects are
- Crystallization of affinity purifed complex I to solve its 3D structure
- Site directed mutagenesis of complex I for structure/function analysis
- Functional analysis of wild-type and mutant analysis, including the measurement of proton translocation and ROS formation.
More recently, Dr. Brandt has expanded his studies to mitochondria as a whole and redox-signaling in order to bridge classical bioenergetics and the exciting developments in cell biology and the central role of mitochondria in apoptosis, degenerative disorders and ageing that has been emerging in recent years.