PhD. Professor of Experimental Hepatology. Head of the Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, University of Amsterdam. Ronald Oude Elferink did his PhD. in biochemistry and has a long lasting interest in the physiological function of various ABC transporters and P-type ATPases. In particular, he studies the role these transporters play in bile formation and oral bioavailability of drugs. Along with these studies he unraveled the mechanism of various cholestatic liver diseases. More recently, the interest broadened to other complications of cholestasis such as chronic itch. Factors have been identified that accumulate in the enterohepatic circulation and that are (indirectly) responsible for chronic activation of neuronal itch pathways. Dr. Oude Elferink also studies the function of bile salts as hormones and their role in lipid homeostasis of the liver. Besides these (patho)physiological studies he is also interested in the role that P4 ATPases (which are lipid flippases) play in intracellular membrane trafficking. Dr. Oude Elferink is present or past member of various editorial and scientific boards and is now co-executive editor of BBA Molecular Basis of Disease.
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