Guide for Authors

  • Zaven Khachaturian, PhD, Editor-in-Chief
    451 Hungerford Drive, Suite 119-355
    Rockville, MD 20850
    Tel: 301-294-7201
    Fax: 301-294-7203

    Ara Khachaturian, PhD, Executive Editor
    Tel: 301-309-6730
    Fax: 301-294-7203

    Information for Authors

    Aims & Scope:

    The mission of Alzheimer's & Dementia: The Journal of theAlzheimer's Association (Alzheimer's & Dementia) is to bridgethe knowledge gaps across a wide range of bench-to-bedsideinvestigation. Alzheimer's & Dementia publishes the results ofstudies in: behavior, biochemistry, genetics, molecular biology,pharmacology, physiology, protein chemistry, neurology, neuropathology,psychiatry, geriatrics, neuropsychology, epidemiology,sociology, health services research, health economics, politicalscience and public policy. Alzheimer's & Dementia emphasizesinterdisciplinary investigations and integrative/translational articlesrelated to: etiology, risk factors, early detection, disease modifyinginterventions, prevention of dementia, and applications ofnew technologies in health services. The Journal will publish onlyoriginal contributions in the following forms: • comprehensivereviews; • research articles; • information on clinical trials; •short reports; • in-depth perspectives/open-peer commentaries; •theoretical and/or translational papers that attempt to integrateknowledge across disciplines; • history and politics of science/brief biographies, and • abstracts of papers presented at internationalmeetings.
    Negative results, particularly clinical trials, arepublished as short communications.

    The ultimate objective is to create a novel forum for: • rapidcommunication of new findings, ideas or perspectives; • disseminatingknowledge, across the spectrum of basic to clinical studies,necessary for optimal translation of research findings into practicalapplications/interventions; • integrating knowledge across disciplines;• increasing knowledge in diverse disciplines to promoteearly detection/diagnosis and/or interventions; • formulating newtheories and/or strategies for the rigorous testing of theories ortheir predictions; • identifying promising new directions of research;and • providing the scientific impetus for new initiatives orpublic policies concerning research on prevention and new modelsof health services.

    Instructions for Authors

    Review Articles:
    Comprehensive Reviews are commissioned papers by the editors to provide comprehensive and balanced coverage of a timely and/or controversial issue by a recognized authority. The invited review should integrating different points of view on ground-breaking, fast-moving or contentious topics with the objective of translating, informing or educating a wide multi-disciplinary audience about varying perspective. Reviews should provide a brief overview or background of critical issues and then concentrate on setting recent findings in context. It is crucial for all Reviews, particularly those tackling controversial topics, to provide a well-balanced view of developments; authors must never concentrate unduly on their own research. Reviews, unlike Research Articles, do allow some speculation designed to foster the formulation or testing of new hypothesis.

    Reviews must include an abstract of approximately 150 words. Length may not exceed 15,000 words, a maximum of 60 references, no more than six figures, boxes or tables.

    Perspectives and Open-Peer Commentaries:
    Perspectives and open-peer commentaries provide personal in-depth viewpoints, rather than a review, on hotly debated topics; controversial theoretical, research or policy issues. Perspectives should: a) stimulate debate, b) present new models or hypotheses, c) suggest future experiments, directions of research or policies and/or, d) speculate on the meaning/interpretation of new discoveries/data. Articles that merely outline recent advances rather than provide a though provoking opinion on them are not suitable for this section of the journal.

    Perspectives must include an abstract of approximately 150 words. Length of a Perspective article may not exceed 5,000 words, a maximum of 50 references, no more than six figures, boxes or tables. Open-peer commentaries may include an abstract of approximately 150 words. Length of Open-Peer Commentaries may not exceed 1,500 words, a maximum of 20 references, no more than two figures, boxes or tables.

    Research Articles:
    Research articles cover hypothesis driven research or evidence-based validation studies in any of the following generic areas of study: Biology, Chemistry, Clinical/Medical Interventions, Behavior/Neuropsychology, Social Sciences, Nursing, Health Economics, Health Services Research and Public Policy. Manuscripts should include: a) Structured Abstract, b) Background, c) Methods, d) Results, e) Discussion, f) References, g) Acknowledgements/Conflicts/Funding Sources and, h) Key Words. The manuscript, and specifically the abstract, should be written such that a diverse audience will understand the central research question and the significance of the findings or conclusion of the study.

    Research articles must include an abstract of approximately 150 words. Length may not exceed 3,500 words, a maximum of 50 references, no more than six figures, boxes or tables.

    Short Reports:
    Short Reports are brief communications dealing with Case Studies or information on Clinical Trials [including the negative results and/or adverse events in clinical studies]. Short Reports will also cover brief articles on the utility or potential applications of a new technique, instruments or analytical approaches; rather than the detail of the technique per se, which can be references for readers interested in complete technical details. These articles should educate and inform readers by comparing or contrasting new approaches/techniques with established ones and highlighting the pros and cons of each.

    Short Reports must include an abstract of approximately 150 words. Length may not exceed 1,500 words, a maximum of 20 references, no more than two figures, boxes or tables.

    Policy Forum:
    Policy Forum manuscripts generally will cover topic related to "Science and Society" that might be relevant and/or interest to a broader audience. Policy Forum will include papers on: history and politics of science, brief biographies and policy analysis. The main aim of the Policy Forum articles is simply to tell an exciting story on an interesting topic; the style should be conversational and newsy. Length may not exceed 5,000 words, a maximum of 50 references, no more than six figures, boxes or tables.

    Letters are welcomed brief communications relating to the content of earlier issues of ADJ or general topics of interest. Letters relating to earlier issues of ADJ will be sent to the appropriate authors for review and to give them an opportunity to reply. Previously unpublished data, however, will not be considered.

    Length may not exceed 750 words, a maximum of 10 references, no more than one figure.

    Research News:
    Research News is designed to highlight recent events, advances or developments (e.g., grants awarded, new funding opportunities, calendar of events, conference reports and abstracts of papers presented at international meetings) that might be a particular interest to the research community. The articles should inform not only a general audience but also offer an expert a balanced interpretation of the advances, developments or events being reported. The article should be restricted to report only novel and interesting information. Articles should be written in a lively style, giving brief essential background, putting recent advances in context and providing insight on future perspectives and direction. Rather than including extensive background information, the reader should be directed, via a citation, to an appropriate review article or text.

    Research News articles must include a "summary lead" that may not exceed 50 words. The summary lead is the first few sentences that summarizes the event and answers the questions: Who? What? When? Where? Why? How? Length may not exceed 1,500 words, a maximum of 20 references, no more than two figures, boxes or tables.

    Manuscript Submission: Alzheimers & Dementia uses a Web-basedonline manuscript submission and review system. Pleasevisit to submit your manuscript electronically.The Web site guides authors stepwise through the creationand uploading of the various files. Note that original sourcefiles, not PDF files, are required. Authors may send queries concerningthe submission process manuscript status or journal proceduresto the Editorial Office. Once the submission files areuploaded the system automatically generates electronic (PDF)proof, which is then used for reviewing. All correspondence,including the Editor's decision and request for revisions, will be bye-mail. Articles will be published in English. International authorswho are not fluent in the English language should seek help in thepreparation of their manuscripts. Such assistance will enhance thereview process and greatly reduce the time to publication, if thearticle is accepted.

    Provisional or final acceptance is based on originality, scientificaccuracy, relevance, clarity, and topical balance of the Journal.Authors should suggest the names (with contact information) of5-7 potential reviewers for the manuscript. Every attempt will bemade to use at least one suggested reviewer. A request to submita revised manuscript does not guarantee acceptance of the revisedmanuscript, only that it will be reconsidered by the reviewers.Decisions will be communicated to the corresponding author byemail.

    The Elsevier Author Gateway [ ] providesa means to track accepted articles and set up e-mail alerts toinform you of when an article's status has changed. You can finddetailed artwork guidelines, copyright information, frequentlyasked questions and more. Contact details for questions arisingafter acceptance of an article, especially those relating to proofs,are provided after registration of an article for publication.

    Responsibilities of Authorship: As a condition of authorship, allauthors must be willing to take responsibility for the entire manuscript.Multi-authored manuscripts should have a declaration ofeach author's contributions in the submission cover letter. Theform will be sent to the corresponding author when the manuscriptis received by the Publisher.

    Copyright: Publications are copyrighted for the protection of theauthors and the publisher. A Transfer of Copyright Agreement willbe sent to the author who submits the manuscript. The correspondingauthor must sign and returned the completed form transferringcopyright ownership of the manuscript to Elsevier Inc. before thearticle can be published.

    Conflict of Interest Disclosure: The authors should disclose anyrelationships that might have the appearance of a "conflict ofinterest" on the title page of the paper. Should there be anyfinancial association [e.g., grants, contracts, consultancy, honoraria,advisory board memberships, equity share, etc] between anyof the authors and the financial beneficiaries [e.g., commercialcompany] of a product that figures prominently or is discussed inthe article, the author(s) should disclose such association. Editorsreserve the right to reject an article on the basis of a significantconflict of interest. If the article is accepted for publication, thedisclosure statement may be published. When no competing interestsare present the disclosure statement should confirm such.

    Ethics—Protection of Human Subjects and Animal Welfare: Authorsshould comply with all the relevant provisions of the NationalInstitutes of Health (NIH) Grants Policy Statement concerning:Ethical and Safe Conduct in Science and OrganizationalOperations, Requirements Affecting the Rights and Welfare ofIndividuals as Research Subjects, Patients or Recipients of Service,and Animal Welfare guidelines outlined in the "Public PolicyRequirements and Objectives" [ see ]

    Permissions: The inclusion of any copyrighted material or previouslypublished material [e.g., direct quotations, tables, or illustrations]must be accompanied by written permission for use fromthe copyright owner and original authors along with completeinformation about the original source. Authors are responsible forobtaining permission and payment of any fees associated withreuse.

    Potential Reviewers: Authors are encouraged to suggest the namesof potential peer-reviewers that do not have any conflicts to assistwith a prompt and fair review process. The submission lettershould include the names, mailing addresses, phone and fax numbers,and e-mail addresses of 5-7 potential reviewers with appropriateexpertise to evaluate the manuscript.

    Proofs: Corrections to the proofs greater than 10% will be chargedto the author. Authors will not be held accountable for errors thatoccur in the production or print processes.

    Offprints: Offprint order forms will be sent to authors beforearticles are published. Reprints in quantity must be purchased fromthe publisher.

    Embargo — Public Presentation/Media Releases: All manuscriptsaccepted for publication in Alzheimer's & Dementia will be embargoeduntil the posted publication date/time by Elsevier. Authorsand their institutions are expected to abide by the copyright agreementand refrain from disclosing to media or the public findings ofan accepted manuscript prior to embargo period [publication].

    Style of Manuscript

    General Format:

    • Manuscripts should be typed double-spaced, and numbered,with wide margins. Computer-generated illustrations must beof the high quality of professional line drawings or they willnot be accepted.
    • The title page should contain: title of paper; author(s); laboratoryor institution of origin with city, state, zip code, andcountry; complete address for mailing proofs; telephone, faxnumber, and email address (when available, the email addresswill appear in the correspondence footnote of the publishedarticle).
    • References, footnotes, and legends for illustrations should betyped on separate sheets, double spaced.
    • Illustrations should be identified with figure number and author(s) name; when necessary the top should be clearlymarked.
    • Each table should be typed on a separate sheet and doublespaced.
    • All dimensions and measurements must be specified in themetric system. Standard nomenclature, abbreviations andsymbols, as specified by Royal Society Conference of Editors.Metrication in Scientific Journals. Am. Scient. 56:159-164; 1968, should be used throughout.
    • Italics should not be used for the purpose of emphasis.
    • Brief Communications should be restricted to six typewrittenpages, including references, and should not present more thanone figure and one table, or two figures, or two tables.

    Title: The title should not be longer than 85 characters, includingspaces between words. Only the first word of the title should becapitalized.

    Length of Paper: The Editors insist upon clear, concise statementof facts and conclusions. Fragmentation of material into numerousshort reports is discouraged. All accepted papers are subject toeditorial revision and copyediting. Authors should avoid redundancybetween sections of text and illustrations and text. TheEditors may recommend that appendices and tables containingextensive data be published in the electronic version of Alzheimer's & Dementia and only referenced in a footnote in the printedition.

    Abstract: Each paper submitted must be accompanied by a structuredabstract of 150 words or less to appear after the title. Theabstract should be suitable for use by abstracting journals and mustinclude the following headings: Background, Methods, Results,and Conclusion(s). A list of 5-15 keywords or short phrases suitablefor indexing terms should be typed at the bottom of theabstract page accompanying the manuscript. These terms will beprinted with the paper following the abstract.

    Headings: All headings should be numbered, for example, 1.Introduction, 2. Methods, 2.1. Study population, etc. Capitalize thefirst word only for all headings.

    Footnotes: If more than one author, the corresponding authorshould be indicated with an asterisk. If there is more than oneaffiliation, use a superior letter for each one. Use superior numbersfor any other footnotes to authors' names, such as a currentaddress. Text footnotes should not be used; the material should beincorporated into the text. Table footnotes: see Tables.

    Abbreviations: Complex terms used frequently in the manuscriptmay be abbreviated. The manuscript should include a list of allabbreviations used. Abbreviations are placed in parentheses at firstuse in the abstract and again at first use in the text.

    References: References should not exceed 50 in number. Referenceformat should conform to that set forth in "Uniform Requirementsfor Manuscripts Submitted to Biomedical Journals" ( ) and journal abbreviations should conform to thestyle used in the Cumulated Index Medicus. Cite references, figures,and tables in numeric order according to the first mention inthe text. Accuracy of reference data is the responsibility of theauthor. Verify all references against original sources. "In press"citations must have been accepted for publication and the name ofthe journal or book publisher must be included. The style ofcitation should be as follows:

    Journals: authors' last names and initials; title of article;journal name; date; volume number, and inclusive pages (listall authors when six or fewer; when seven or more, list sixand add et al):

    Graeber GM, Gupta NC, Murray GF. Positron emission tomographicimaging with fluorodeoxyglucose is efficacious inevaluating malignant pulmonary disease. J Thorac CardiovascSurg 1999;117:719-27.

    Lytle BW, Blackstone EH, Loop FD, Houghtaling PL, ArnoldJH, Akhrass R, et al. Two internal thoracic artery grafts arebetter than one. J Thorac Cardiovasc Surg 1999;117:855-72.

    Books: authors' last names and initials; chapter title, editor'sname, book title, edition, city, publisher, date, and pages:

    Mollnes TE. Analysis of in vivo complement activation: In:Herzenberg LA, Weir DM, Herzenberg LA, Blackwell C,editors. Weir's Handbook of experimental immunology. Volume78, 5th ed. Boston: Blackwell Science; 1997, p. 78.1-78.8.

    Acknowledgments: Authors must provide proper recognition topublic funding agencies [e.g., agency name, grant title and number]and/or private funding source or the sponsor of the study aswell as those that made significant contribution to the project.

    Figures: Figures must be of professional quality. When possible,please use or supply first-generation artwork. Figures are encouragedin electronic format with a printed proof on glossy or highqualityphotographic printer paper and should be at least 5 incheswide. Figures may be black and white line art, graphs, halftones(photographs), or color. TIFF, EPS, or PDF formats are recommendedfor electronic artwork. Line art should have a minimumresolution of 1000 dpi, halftone art a minimum of 300 dpi, andcombination art (line/halftone) a minimum of 500 dpi. MS Officefiles (Word, PowerPoint, and Excel) are also accepted if they meetcertain standards. Color figures should be submitted in actual sizeand authors will be responsible for costs associated with colorreproduction.

    When possible all lettering should be within the frame-work of theillustration; likewise the key to symbols should be on the face ofthe chart. The following standard symbols should be used as theyare easily available to the printer: + &ogr; ˙ ▪ ▴. Actual magnificationof all photomicrographs should be provided. Dimension scaleshould be indicated.

    For help with preparing electronic artwork for both on-screenreview and eventual publication visit the Elsevier Author Gateway[ ].

    Video Clips Alzheimer's & Dementia encourages authors to submit video clips to be published on the Journal's website at as illustrations incorporated into articles for publication in the print journal. All video clips are subject to peer review.

    The following file formats are accepted:
    • MPEG-1 or MPEG-2 (.mpg)
    • QuickTime (.mov)
    • Audio/Video Interface (.avi)
    • CompuServe GIF (.gif)

    Alzheimer's & Dementia does not edit video clips, but reviewers may suggest changes.


    • Maximum cumulative length of videos or animated computer graphics is 4.5 minutes.
    • Files may be divided into several smaller clips not to exceed 4.5 minutes in total.
    • Each video segment file cannot exceed 50 MB. The submission program will time out if the file size is larger than 50 MB.
    • Please ZIP the file and upload the zipped file to hasten the upload time.
    • If the video or animation is divided into several clips:
    • Identify each clip at the beginning of the section, e.g., Video Clip 1.
    • Each clip or graphic should be saved as a separate file.
    • Complete legends for each video clip must be included in the manuscript.
    • Videos must be cited in the text of the manuscript.
    • Sound tracks may be included as appropriate.

    Tables: Table numbers should be Arabic, followed by a period anda brief heading. Explanatory matter should be in footnotes, not aspart of the title. Begin each table on a separate page. Use same sizetype as in text where possible. Supply a brief heading for eachcolumn. Do not use vertical lines between columns. Use horizontallines above and below the column headings and at the bottom ofthe table only. Use extra space to delineate sections within thetable. Abbreviations used in the table must be defined in a footnoteto the table. Indicate footnotes in this order: *,†, ‡, §, ¶, #, **, ††,‡‡, §§, ¶¶, ##. Table footnotes should be indicated in the body ofthe table in order of their appearance with superior letters. Statisticalmeasures should be indicated with symbols: *, **, etc. Tablesmust not duplicate material in text or illustrations. Statistical measuresof variation, SD, SE, etc., should be identified. Analysis ofvariance tables should not be submitted but significant F's shouldbe incorporated where appropriate within the text. The appropriateform for reporting F value is: F (11, 20) = 3.05, p < 0.01.

    Formulas and Equations: Structural chemical formulas, processflow-diagrams, and complicated mathematical expressions shouldbe kept to a minimum. Usually chemical formulas and flowdiagramsshould be provided for reproduction as line cuts. Allsubscripts, superscripts, Greek letters, and unusual characters mustbe clearly identified.

    Drugs: When possible, provide generic rather than trademarkednames of drugs. Proprietary (trademarked) names should be capitalized.The chemical name should precede the trade, popularname, or abbreviation of a drug the first time it occurs. Tradenames of drugs and other products must not appear in the title. Thetrade name may appear once in the abstract and once in theintroduction or methods section; all other mention of the productmust be in the form of the generic name.

    Anesthesia: In describing surgical procedures on animals, the typeand dosage of the anesthetic agent should be specified. Curarizingagents are not anesthetics; if these were used, evidence must beprovided that anesthesia of suitable grade and duration was employed.

    Updated May 2012


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