BBRC Landmark Breakthroughs
Papers cited 1000 times or more, 1959-1999
Articles are linked to their PubMed listing.
1.   Denhardt, D.T. (1966) A membrane-filter technique for the detection of complementary DNA. Biochem. Biophys. Res. Commun. 23, 641-646.
2.   Fraker, P.J. and Speck, J.C. Jr. (1978) Protein and cell membrane iodinations with a sparingly soluble chloramide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril. Biochem. Biophys. Res. Commun. 80, 849-857.
3.   Shapiro, A.L., Vinuela, E. and Maizel, J.V. Jr. (1967) Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels. Biochem. Biophys. Res. Commun. 28, 815-820.
4.   Marion, D. and Wuthrich, K. (1983) Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurement of 1H-1H spin-spin coupling constants in proteins. Biochem. Biophys. Res. Commun. 113, 967-974.
5.   Schechter, I. and Berger, A. (1967) On the size of the active site in proteases. I. Papain. Biochem. Biophys. Res. Commun. 27, 157-162.
6.   Adelberg, E.A., Mandel, M., and Chen, G.C.C. (1965) Optimal conditions for mutagenesis by N-methyl-N’-nitro-N-nitrosoguanidine in Escherichia coli K12. Biochem. Biophys. Res. Commun. 18, 788-795.
7.   Tamaoki, T., Nomoto, H., Takahashi, I., Kato, Y., Morimoto, M. Tomita, F. (1986) Staurosporine, a potent inhibitor of phospholipid/Ca++dependent protein kinase. Biochem. Biophys. Res. Commun. 135, 397-402.
8.   Scherrer, K. and Darnell, J.E. (1962) Sedimentation characteristics of rapidly labelled RNA from HeLa cells. Biochem. Biophys. Res. Commun. 7, 486-490.
9.   Hewish, D.R. and Burgoyne, L.A. (1973) Chromatin sub-structure. The digestion of chromatin DNA at regularly spaced sites by a nuclear deoxyribonuclease. Biochem. Biophys. Res. Commun. 52, 504-510.
10.   Glenner, G.G. and Wong, C.W. (1984) Alzheimer’s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120, 885-890.
11.   Benesch, R. and Benesch, R.E. (1967) The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin. Biochem. Biophys. Res. Commun. 26, 162-167.
12.   Rance, M., Sorensen, O.W., Bodenhausen, G., Wagner, G., Ernst, R.R. Wuthrich, K. (1983) Improved spectral resolution in cosy 1H NMR spectra of proteins via double quantum filtering. Biochem. Biophys. Res. Commun. 117, 479-485.