WTEC Panel Report on Tissue Engineering Research book cover

WTEC Panel Report on Tissue Engineering Research

WTEC Panel on Tissue Engineering Research is a comparative review of tissue engineering research and development activities in the United States, Japan, and Western Europe conducted by a panel of leading U.S. experts in the field. This book covers biomaterials, cells, biomolecules, non-medical applications, engineering design, informatics, and legal and regulatory issues associated with tissue engineering research and applications. This document will serve as a basis for continued dialogue within nations' tissue engineering research and development community and with other important stakeholders, providing guidance for future programs. This text highlights the necessity for providing continued and enhanced resources to further the progress in tissue engineering, harness developments, and maintain scientific and economic leadership.

Hardbound, 268 Pages

Published: December 2002

Imprint: Academic Press

ISBN: 978-0-12-484150-5

Contents


  • Foreword

    List of Figures

    List of Tables

    Executive Summary

    1. Introduction

    Background: The Significance of Tissue Engineering

    History of Tissue Engineering

    Promise of Tissue Engineering

    Other Applications

    Emerging Industry of Tissue Engineering

    Objectives of the WTEC Study

    Scope and Methodology

    Vision for the Future

    Acknowledgements

    References

    2 Biomaterials

    Introduction

    U.S. R&D Activities

    Japanese R&D Activities

    European R&D Activities

    Summary

    References

    3 Cells

    Introduction

    Analysis of Current State of the Art and Factors Influencing Progress

    Control of Cell Proliferation and Differentiation

    U.S. R&D Activities

    Background

    Current Efforts

    Future Position

    R&D Activities in Europe

    Japan

    Summary

    References

    4 Biomolecules

    Introduction

    Gene Transfer

    Angiogenic Factors/Growth Factors

    Differentiation Factors

    Bone Morphogenic Proteins

    References

    5 Cell-Based Technologies: Non-Medical Applications

    Introduction

    Overview of R&D Activities

    Summary

    6 Engineering Design Aspects of Tissue Engineering

    Introduction

    Bioreactor Technology

    Preservation of Cells and Engineered Tissues

    Mass Transport Issues Following Implantation

    Biomechanics Issues

    Summary

    References

    7 Informatics and Tissue Engineering

    Introduction

    Informatics Components That Will Ultimately Support Tissue Engineering

    U.S. R&D Activities

    European R&D Activities

    Japanese R&D Activities

    Summary

    References

    8 Legal and Regulatory Issues

    Introduction

    FDA Regulation

    Other Considerations Relevant to Engineered Tissues

    Regulation of Pharmaceutical/Medical Human Tissue Products in Europe

    Regulation of Pharmaceutical/Medical Human Tissue Products in Japan

    Conclusion

    References

    Appendices

    A. Biographies of Panelists

    B. Site Reports-Europe

    bwA, Aachen Centre of Competence: Biomaterials

    Cell Lining GmbH

    Berlin Workshop

    ERA Consulting (UK), Ltd

    ETH Zurich

    European Agency for the Evaluation of Medicinal Products (EMEA)

    European Molecular Biology Laboratory (EMBL)

    German Cancer Research Center (DKFZ)

    German Heart Institute

    Humboldt University of Berlin, Charite

    Biomaterial and Tissue Repair Laboratory (INSERM)

    Imperial College of Science, Technology and Medicine

    Imperial College of Science, Technology and Medicine

    University of Glasgow

    IsoTis (Technical Report)

    IsoTis (Regulatory Report)

    Kirchhoff Institute of Physics (KIP)

    Manchester University

    Max Planck Institute for Polymer Research

    MeVis

    Smith & Nephew Group Research Centre

    University of Freiburg

    University of Koln

    University of Regensburg

    University of Twente

    C. Appendix C. Site Reports-Japan

    Hokkaido University

    Japan Tissue Engineering Company, Ltd

    Keio University

    Kyoto University

    Kyushu University

    Nippon Telegraph and Telephone Corporation (NTT) Basic Research Laboratories

    Nagoya University

    National Cancer Center Research Institute

    National Institute for Advanced Interdisciplinary Research (NAIR)

    National Institute of Bioscience and Human Technology

    Institute of Physical and Chemical Research (RIKEN) Cell Bank

    Tokyo Institute of Technology

    Tokyo Women's Medical University

    University of Tokyo

    University of Tsukuba

    D. Summary of the June 2000 U.S. Review Workshop

    E. The Federal Investment in Tissue Engineering


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