WTEC Panel Report on Tissue Engineering Research

By

  • Larry McIntire

WTEC Panel on Tissue Engineering Research is a comparative review of tissue engineering research and development activities in the United States, Japan, and Western Europe conducted by a panel of leading U.S. experts in the field. This book covers biomaterials, cells, biomolecules, non-medical applications, engineering design, informatics, and legal and regulatory issues associated with tissue engineering research and applications. This document will serve as a basis for continued dialogue within nations' tissue engineering research and development community and with other important stakeholders, providing guidance for future programs. This text highlights the necessity for providing continued and enhanced resources to further the progress in tissue engineering, harness developments, and maintain scientific and economic leadership.
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Book information

  • Published: December 2002
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-484150-5


Table of Contents


Foreword

List of Figures

List of Tables

Executive Summary

1. Introduction

Background: The Significance of Tissue Engineering

History of Tissue Engineering

Promise of Tissue Engineering

Other Applications

Emerging Industry of Tissue Engineering

Objectives of the WTEC Study

Scope and Methodology

Vision for the Future

Acknowledgements

References

2 Biomaterials

Introduction

U.S. R&D Activities

Japanese R&D Activities

European R&D Activities

Summary

References

3 Cells

Introduction

Analysis of Current State of the Art and Factors Influencing Progress

Control of Cell Proliferation and Differentiation

U.S. R&D Activities

Background

Current Efforts

Future Position

R&D Activities in Europe

Japan

Summary

References

4 Biomolecules

Introduction

Gene Transfer

Angiogenic Factors/Growth Factors

Differentiation Factors

Bone Morphogenic Proteins

References

5 Cell-Based Technologies: Non-Medical Applications

Introduction

Overview of R&D Activities

Summary

6 Engineering Design Aspects of Tissue Engineering

Introduction

Bioreactor Technology

Preservation of Cells and Engineered Tissues

Mass Transport Issues Following Implantation

Biomechanics Issues

Summary

References

7 Informatics and Tissue Engineering

Introduction

Informatics Components That Will Ultimately Support Tissue Engineering

U.S. R&D Activities

European R&D Activities

Japanese R&D Activities

Summary

References

8 Legal and Regulatory Issues

Introduction

FDA Regulation

Other Considerations Relevant to Engineered Tissues

Regulation of Pharmaceutical/Medical Human Tissue Products in Europe

Regulation of Pharmaceutical/Medical Human Tissue Products in Japan

Conclusion

References

Appendices

A. Biographies of Panelists

B. Site Reports-Europe

bwA, Aachen Centre of Competence: Biomaterials

Cell Lining GmbH

Berlin Workshop

ERA Consulting (UK), Ltd

ETH Zurich

European Agency for the Evaluation of Medicinal Products (EMEA)

European Molecular Biology Laboratory (EMBL)

German Cancer Research Center (DKFZ)

German Heart Institute

Humboldt University of Berlin, Charite

Biomaterial and Tissue Repair Laboratory (INSERM)

Imperial College of Science, Technology and Medicine

Imperial College of Science, Technology and Medicine

University of Glasgow

IsoTis (Technical Report)

IsoTis (Regulatory Report)

Kirchhoff Institute of Physics (KIP)

Manchester University

Max Planck Institute for Polymer Research

MeVis

Smith & Nephew Group Research Centre

University of Freiburg

University of Koln

University of Regensburg

University of Twente

C. Appendix C. Site Reports-Japan

Hokkaido University

Japan Tissue Engineering Company, Ltd

Keio University

Kyoto University

Kyushu University

Nippon Telegraph and Telephone Corporation (NTT) Basic Research Laboratories

Nagoya University

National Cancer Center Research Institute

National Institute for Advanced Interdisciplinary Research (NAIR)

National Institute of Bioscience and Human Technology

Institute of Physical and Chemical Research (RIKEN) Cell Bank

Tokyo Institute of Technology

Tokyo Women's Medical University

University of Tokyo

University of Tsukuba

D. Summary of the June 2000 U.S. Review Workshop

E. The Federal Investment in Tissue Engineering