Volatile Biomarkers book cover

Volatile Biomarkers

Non-Invasive Diagnosis in Physiology and Medicine

Volatile organic compounds (VOCs) in exhaled breath, sweat or urine carry much information on the state of human health. The role of VOCs in clinical diagnosis and therapeutic monitoring is expected to become increasingly significant due to recent advances in the field. Volatile Biomarkers: Non-Invasive Diagnosis in Physiology and Medicine includes the latest discoveries and applications for VOCs from the world's foremost scientists and clinicians working in this emerging analytic area.


chemists, biochemists, cell biologists, physiologists, and clinicians with an interest in breath analysis

Hardbound, 600 Pages

Published: May 2013

Imprint: Elsevier

ISBN: 978-0-444-62613-4


  • "The book appropriately starts with a discussion of interpreting breath analyses, and readers quickly learn that the lack of standardization for specimen collection, patient preparation, or laboratory analytical methodology has greatly limited its applicability to assessing human health or disease…This book nicely summarizes the current state of the art of VOC detection and analysis for a variety of interesting applications."--Doody.com, November 23, 2013
    "Volatile organic compounds are continuously generated by the human body and partially emitted in exhaled breath and through the skin, as well as other pathways…Medical, biological, chemical, and engineering specialists review developments in breath analysis since 2005, when the previous volume was completed."--Reference & Research Book News, October 2013


  • A: Interpretation of Breath Analysis Data
      1. Mathematical and Statistical Approaches for Interpreting Biomarker Compounds in Exhaled Human Breath
      2. Issues and Challenges in Human Breath Research: Perspectives from Our Experience
    B: Real-Time Analysis of Exhaled Breath
      3. Physiological Modeling for Analysis of Exhaled Breath
    C: Physiological and Clinical Studies
      4. Recent SIFT-MS Studies of Volatile Compounds in Physiology, Medicine and Cell Biology
      5. The Analysis of Oral Air by Selected Ion Flow Tube Mass Spectrometry Using Indole and Methylindole as Examples
      6. Smokers Breath as Seen by Proton-Transfer-Reaction Time-of-Flight Mass Spectrometry (PTR-TOF-MS)
      7. Exhaled Breath Analysis in Occupational Medicine
      8. Volatile Organic Compounds in Human Breath: Biogenic Origin and Point-of-Care Analysis
      9. Breath Analysis in Critically Ill Patients-Potential and Limitations
      10. Analysis of Cancer Biomarkers in Exhaled Breath and Comparison with Sensory Indications by Dogs
    D: Nitric Oxide, No, and Carbon Monoxide, Co
      11. Added Value with Extended NO Analysis
      12. Carbon Monoxide as an Exhaled Biomarker of Pulmonary Diseases
      13. Exhaled Nitric Oxide in Clinical Practice: Recent Advances and New Challenges
    E: Clinical Breath Tests
      14. An Update on 13C-Breath Tests: The Transition to Acceptability into Clinical Practice
    F: Development and Use Of Sensors
      15. Sensors for Exhaled Gas Analysis: An Analytical Review
      16. Arrays of Nanomaterial-Based Sensors for Breath Testing
      17. Smart Sensor Systems for Human Health Breath Monitoring Applications
      18. VOC Analysis by SIFT-MS, GC-MS, and Electronic Nose for Diagnosing and Monitoring Disease
    G: Exhaled Breath Condensate (Ebc) And Particulates
      19. Measurement of Biomarkers of Oxidative Stress and Airway Inflammation in Exhaled Breath Condensate: Methodology and Potential Applications in Patients with COPD and Healthy Smokers
      20. Particles in Exhaled Air-A Novel Method of Sampling Non-Volatiles in Exhaled Air
    H: Volatiles Of Microbial Origin: Urine, Stool and In Vitro Cultures
      21. Challenges in the Investigation of Volatile Disease Biomarkers in Urine
      22. Volatile Organic Compounds (VOCs) Found in Urine and Stool
      23. Volatile Organic Compounds (VOCs) Released by Pathogenic Microorganisms in vitro: Potential Breath Biomarkers for Early-Stage Diagnosis of Disease
    I: Urban Search and Rescue Operations
      24. Potential Applications of Volatile Organic Compounds in Safety and Security


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