Viruses and Human Disease book cover

Viruses and Human Disease

Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease.

Students and professionals in virology, molecular biology, and microbiology

Hardbound, 480 Pages

Published: September 2007

Imprint: Academic Press

ISBN: 978-0-12-373741-0


  • PRAISE FOR THE PREVIOUS EDITION: "...exceptionally easy to read and full of 'need-to know' material appropriate for students. ...well organized and thoughtfully prepared." -DOODY'S


  • Preface to the Second Edition

    Chapter 1. Overview of Viruses and Virus Infection


    Classification of Viruses

    An Overview of the Replication Cycle of Viruses

    Effects of Virus Infection on the Host Cell

    Epidemiology: The Spread of Viruses from Person to Person

    Further Reading

    Chapter 2. The Structure of Viruses


    Helical Symmetry

    Icosahedral Symmetry

    Nonenveloped Viruses with More Complicated Structural Features

    Enveloped Viruses

    Assembly of Virions

    Stability of Virions

    Further Reading

    Chapter 3. Plus-Strand RNA Viruses


    Family Picornaviridae

    Family Caliciviridae

    Family Hepeviridae

    Family Astroviridae

    Family Togaviridae

    Family Flaviviridae

    Family Coronaviridae

    Family Arteriviridae

    Family Roniviridae

    The Plus-Strand RNA Viruses of Plants

    Origin and Evolution of Plus-Strand RNA Viruses

    Further Reading

    Chapter 4. Minus-Strand RNA Viruses


    Overview of the Minus-Strand RNA Viruses

    Family Rhabdoviridae

    Family Paramyxoviridae

    Family Filoviridae

    Family Bornaviridae

    Family Orthomyxoviridae

    Family Bunyaviridae

    Family Arenaviridae

    Evolution of Minus-Strand RNA Viruses

    Further Reading

    Chapter 5. Viruses That Contain Double-Stranded RNA: Family Reoviridae


    Overview of the Family Reoviridae

    Further Reading

    Chapter 6. Viruses Whose Life Cycle Uses Reverse Transcriptase


    Family Retroviridae

    Family Hepadnaviridae

    Further Reading

    Chapter 7. DNA-Containing Viruses


    Family Poxviridae

    Family Herpesviridae

    Replication of Herpesviruses

    Family Adenoviridae

    Family Polyomaviridae

    Family Papillomaviridae

    Family Parvoviridae

    Torque Teno Virus: A Newly Described Human Virus

    Further Reading

    Chapter 8. Emerging and Reemerging Viral Diseases

    Bat-Associated Viruses

    Viruses Associated with Birds

    Viruses Associated with Primates

    Viruses Associated with Rodents

    Further Reading

    Chapter 9. Subviral Agents


    Defective Interfering Viruses

    Satellites and Satellite Viruses

    Viroids and Virusoids

    Hepatitis δ

    Prions and Prion Diseases

    Prions of Yeast

    Further Reading

    Chapter 10. Host Defenses against Viral Infection and Viral Counterdefenses


    Adaptive Immune System

    Innate Immune System

    Viral Counterdefenses

    Interactions of Viruses with Their Hosts

    Further Reading

    Chapter 11. Gene Therapy


    Virus Vector Systems

    Use of Viruses as Expression Vectors

    Gene Therapy

    Further Reading

    Appendix: References Used for Figures and Tables



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