Viruses and Human Disease


  • Ellen Strauss, California Institute of Technology, U.S.A.
  • James Strauss, California Institute of Technology, U.S.A.

Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease.
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Students and professionals in virology, molecular biology, and microbiology


Book information

  • Published: September 2007
  • ISBN: 978-0-12-373741-0


PRAISE FOR THE PREVIOUS EDITION: "...exceptionally easy to read and full of 'need-to know' material appropriate for students. ...well organized and thoughtfully prepared." -DOODY'S

Table of Contents

Preface to the Second Edition

Chapter 1. Overview of Viruses and Virus Infection


Classification of Viruses

An Overview of the Replication Cycle of Viruses

Effects of Virus Infection on the Host Cell

Epidemiology: The Spread of Viruses from Person to Person

Further Reading

Chapter 2. The Structure of Viruses


Helical Symmetry

Icosahedral Symmetry

Nonenveloped Viruses with More Complicated Structural Features

Enveloped Viruses

Assembly of Virions

Stability of Virions

Further Reading

Chapter 3. Plus-Strand RNA Viruses


Family Picornaviridae

Family Caliciviridae

Family Hepeviridae

Family Astroviridae

Family Togaviridae

Family Flaviviridae

Family Coronaviridae

Family Arteriviridae

Family Roniviridae

The Plus-Strand RNA Viruses of Plants

Origin and Evolution of Plus-Strand RNA Viruses

Further Reading

Chapter 4. Minus-Strand RNA Viruses


Overview of the Minus-Strand RNA Viruses

Family Rhabdoviridae

Family Paramyxoviridae

Family Filoviridae

Family Bornaviridae

Family Orthomyxoviridae

Family Bunyaviridae

Family Arenaviridae

Evolution of Minus-Strand RNA Viruses

Further Reading

Chapter 5. Viruses That Contain Double-Stranded RNA: Family Reoviridae


Overview of the Family Reoviridae

Further Reading

Chapter 6. Viruses Whose Life Cycle Uses Reverse Transcriptase


Family Retroviridae

Family Hepadnaviridae

Further Reading

Chapter 7. DNA-Containing Viruses


Family Poxviridae

Family Herpesviridae

Replication of Herpesviruses

Family Adenoviridae

Family Polyomaviridae

Family Papillomaviridae

Family Parvoviridae

Torque Teno Virus: A Newly Described Human Virus

Further Reading

Chapter 8. Emerging and Reemerging Viral Diseases

Bat-Associated Viruses

Viruses Associated with Birds

Viruses Associated with Primates

Viruses Associated with Rodents

Further Reading

Chapter 9. Subviral Agents


Defective Interfering Viruses

Satellites and Satellite Viruses

Viroids and Virusoids

Hepatitis δ

Prions and Prion Diseases

Prions of Yeast

Further Reading

Chapter 10. Host Defenses against Viral Infection and Viral Counterdefenses


Adaptive Immune System

Innate Immune System

Viral Counterdefenses

Interactions of Viruses with Their Hosts

Further Reading

Chapter 11. Gene Therapy


Virus Vector Systems

Use of Viruses as Expression Vectors

Gene Therapy

Further Reading

Appendix: References Used for Figures and Tables