Preface (P. Angeli, U. Gulini, W. Quaglia). Bernard Belleau: MedicinalChemist. 1925-1989 (D.J. Triggle). Design, anti-HIV activity, cellularpharmacology and conformation of BCH-189 [(±)3TC], a novel nucleosideanalogue (B. Belleau, et al.). Theoretical and practical advantages andlimitations of techniques used in functional pharmacological classificationof drug receptors (T.P. Kenakin, R.A Bond). Is pharmacological analysis ofagonist action useful in medical chemistry? (P. Leff, I.G. Dougall). Thehydrogen bonding of drugs: its experimental determination and role inpharmacokinetics and pharmacodynamics (B. Testa, et al.). Presynapticreceptors modulating transmitter release: physiological and pharmacologicalaspects (M. Raiteri, et al.). Presynaptic auto- and hetero-receptors in thecholinergic regulation of pain (C. Ghelardini, et al.). Heterogeneity of &agr;2-adrenoceptors: clinical aspects (E.S. Vizi, et al.).Histamine H3 receptors: novel ligands and responses (J.C. Schwartz,et al.). Selective alpha adrenergic agents - Differentiation of receptorsubtypes (J.F. DeBernardis, D.J. Kerkman). Stereoisomeric, photoaffinity,affinity and fluorescent probes for characterization of dopamine D1and D2 receptors (J.L. Neumeyer, et al.). Serotonin receptors, 5-HT ligands and receptor modeling (R.A. Glennon, R.B Westkaemper). Excitatoryamino acid receptors: multiplicity and ligand specificity of the NMDA and AMPAreceptor subtypes (P. Krogsgaard-Larsen, et al.). Tricyclic compounds asselective muscarinic antagonists: structure activity relationships andtherapeutic implications (W.G. Eberlein, et al.). Design of high efficacyagonists at cortical muscarinic receptors (J. Saunders). Multidisciplinaryanalysis of muscarinic receptors in guinea-pig isolated ileum, atria anduterus in vitro (R.M. Eglen, et al.). Molecular biology of theGABAA receptor (A.N. Bateson). Potassium channel openers:pharmacology and therapeutic prospects (U. Quast, et al.). L-type calciumchannels and calcium channel ligands (J. Striessnig, H. Glossmann). Centralcholecystokinin receptors : opportunity for drug discovery (G. Gaviraghi, etal.). Drug modeling at cell membrane receptors: the concept of pseudoreceptors(J.P. Snyder, et al.). Concluding comments (D.J. Triggle). Messengers andmodulators - Receptors and enzymes (E.J. Ariëns). Author index. Subjectindex.