Trends in Receptor Research

Edited by

  • P. Angeli
  • U. Gulini
  • W. Quaglia, Department of Chemical Sciences, University of Camerino, Via S. Agostino 1, 62032 Camerino (MC), Italy

Series Editor:

  • H. Timmerman

The 8th Camerino-Noordwijkerhout Symposium has continued along its traditional path of interdisciplinary cooperation. Chemists, biochemists, pharmacologists, biophysicists and physiologists are all involved in the task of improving our knowledge of the mechanisms of drug-receptor interaction and of the heterogeneous nature of biological molecules. In this volume, leading researchers have contributed state of the art information on receptor chemistry. Newest developments are covered with particular reference to receptors of the nervous system; SAR studies; receptor isolation; receptor cloning; receptor topography; biomedical consequences of occupancy; receptor regulation and receptor theory. This will be of great interest to pharmacologists, biochemists and medicinal chemists, as well as a valuable source of reference for medical students and postgraduate students in related fields.
View full description


Book information

  • Published: August 1992
  • Imprint: ELSEVIER
  • ISBN: 978-0-444-88931-7

Table of Contents

Preface (P. Angeli, U. Gulini, W. Quaglia). Bernard Belleau: MedicinalChemist. 1925-1989 (D.J. Triggle). Design, anti-HIV activity, cellularpharmacology and conformation of BCH-189 [(±)3TC], a novel nucleosideanalogue (B. Belleau, et al.). Theoretical and practical advantages andlimitations of techniques used in functional pharmacological classificationof drug receptors (T.P. Kenakin, R.A Bond). Is pharmacological analysis ofagonist action useful in medical chemistry? (P. Leff, I.G. Dougall). Thehydrogen bonding of drugs: its experimental determination and role inpharmacokinetics and pharmacodynamics (B. Testa, et al.). Presynapticreceptors modulating transmitter release: physiological and pharmacologicalaspects (M. Raiteri, et al.). Presynaptic auto- and hetero-receptors in thecholinergic regulation of pain (C. Ghelardini, et al.). Heterogeneity of &agr;2-adrenoceptors: clinical aspects (E.S. Vizi, et al.).Histamine H3 receptors: novel ligands and responses (J.C. Schwartz,et al.). Selective alpha adrenergic agents - Differentiation of receptorsubtypes (J.F. DeBernardis, D.J. Kerkman). Stereoisomeric, photoaffinity,affinity and fluorescent probes for characterization of dopamine D1and D2 receptors (J.L. Neumeyer, et al.). Serotonin receptors, 5-HT ligands and receptor modeling (R.A. Glennon, R.B Westkaemper). Excitatoryamino acid receptors: multiplicity and ligand specificity of the NMDA and AMPAreceptor subtypes (P. Krogsgaard-Larsen, et al.). Tricyclic compounds asselective muscarinic antagonists: structure activity relationships andtherapeutic implications (W.G. Eberlein, et al.). Design of high efficacyagonists at cortical muscarinic receptors (J. Saunders). Multidisciplinaryanalysis of muscarinic receptors in guinea-pig isolated ileum, atria anduterus in vitro (R.M. Eglen, et al.). Molecular biology of theGABAA receptor (A.N. Bateson). Potassium channel openers:pharmacology and therapeutic prospects (U. Quast, et al.). L-type calciumchannels and calcium channel ligands (J. Striessnig, H. Glossmann). Centralcholecystokinin receptors : opportunity for drug discovery (G. Gaviraghi, etal.). Drug modeling at cell membrane receptors: the concept of pseudoreceptors(J.P. Snyder, et al.). Concluding comments (D.J. Triggle). Messengers andmodulators - Receptors and enzymes (E.J. Ariëns). Author index. Subjectindex.