Treatment of Leukemia and Lymphoma


  • David Scheinberg, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.
  • Joseph Jurcic, Memorial Sloan Kettering Cancer Center, New York, New York, U.S.A.

New Treatments of Leukemia and Lymphoma describes the most important advances in the therapy of hematopoietic cancers that have been derived from recent discoveries in cancer cell biology, kinase biochemistry, and immunology. Detailed descriptions of the large number of new and effective agents that have recently become available for the treatment of leukemias and lymphomas as well as an understanding of their mechanisms of action and their integration into current therapy are provided. A number of experimental drug reagents currently in clinical investigation are also discussed. The therapies include conventional anti-metabolites, monoclonal antibodies directed to cell surface receptors, antibodies tagged with toxins and radiopharmaceuticals, inhibitors of specific kinases, stem cell transplants, and engineered T-cells designed to selectively target hematopoietic cancers. The contents of the book will allow practitioners and investigators alike to understand what is current and state of the art as well as what to look for in the future.
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Oncologists, hematologists, cancer researchers, pharmacologists, pharmaceutical and biotechonology company employees


Book information

  • Published: September 2004
  • ISBN: 978-0-12-032952-6

Table of Contents

Kinase Inhibitors in LeukemiaState of the Art Treatment of APLInvestigational Agents in Myeloid Disorders Methodologic Issues in Investigation of Targeted Therapies in AMLPurine Analogues in LeukemiaMonoclonal Antibody Therapy in Lymphoid LeukemiasNative Antibody and Antibody-Targeted Chemotherapy for Acute Myeloid Leukemia Radioimmunotherapy of LeukemiaImmunotoxins and Toxin Constructs in Leukemia/Lymphoma Antibody Therapy of LymphomaVaccines in LeukemiaTherapeutic Idiotype Vaccines for Non-Hodgkin’s Lymphoma Cytokine Modulation of the Innate Immune System in the Treatment of Leukemia and Lymphoma Donor Lymphocyte InfusionsSomatic Cell Engineering and the Immunotherapy of Leukemias and Lymphomas