Translational Endocrinology of Bone

Reproduction, Metabolism, and the Central Nervous System

Edited by

  • Gerard Karsenty, Professor and Chair, Department of Genetics and Development, Columbia University Medical School, New York, NY, USA

The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology.
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Clinical and basic researchers in bone biology and clinician researchers in endocrinology, osteology, rheumatology, and orthopedic surgery.


Book information

  • Published: October 2012
  • ISBN: 978-0-12-415784-2

Table of Contents

1. Introduction

2. Bone Remodelling & Regulation*

3. Food Intake of Bone Formation

4. Central Control of Bone Mass

5. Neuropeptide Y and Bone Formation
6. Serotonin: The Central Link between Bone Mass and Energy Metabolism

6. Gut Serotonin Bone Formation

7. Gut Serotonin and Osteoporosis

8. Regulation of Bone Resoprtion by PPARGamma

10. Regulation of Energy Metabolism by Bone

11. Bone Marrow Fat and Bone Mass

12. Bone Mass and Energy Metabolism in Humans

13. Regulation of Fertility by Bone

14. Molecular Signaling by Osteocalcin

15. Regulation of Phosphate Metabolism by FGF23

16. The Clinical Use of FGF 23

17. Transcriptional Regulation of the Endocrine Function of Bone