Translational Endocrinology of Bone book cover

Translational Endocrinology of Bone

Reproduction, Metabolism, and the Central Nervous System

The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology.


Clinical and basic researchers in bone biology and clinician researchers in endocrinology, osteology, rheumatology, and orthopedic surgery.

Hardbound, 236 Pages

Published: October 2012

Imprint: Academic Press

ISBN: 978-0-12-415784-2


  • 1. Introduction

    2. Bone Remodelling & Regulation*

    3. Food Intake of Bone Formation

    4. Central Control of Bone Mass

    5. Neuropeptide Y and Bone Formation
    6. Serotonin: The Central Link between Bone Mass and Energy Metabolism

    6. Gut Serotonin Bone Formation

    7. Gut Serotonin and Osteoporosis

    8. Regulation of Bone Resoprtion by PPARGamma

    10. Regulation of Energy Metabolism by Bone

    11. Bone Marrow Fat and Bone Mass

    12. Bone Mass and Energy Metabolism in Humans

    13. Regulation of Fertility by Bone

    14. Molecular Signaling by Osteocalcin

    15. Regulation of Phosphate Metabolism by FGF23

    16. The Clinical Use of FGF 23

    17. Transcriptional Regulation of the Endocrine Function of Bone


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