Toxoplasma Gondii

The Model Apicomplexan - Perspectives and Methods

By

  • Louis M. Weiss, Professor of Medicine and Pathology, Albert Einstein College of Medicine of Yeshiva University, New York, U.S.A.
  • Kami Kim, Professor of Medicine, Pathology, and Microbiology & Immunology, Albert Einstein College of Medicine of Yeshiva University, New York, U.S.A.

This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists.

Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.

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Audience

Parasitologists, Cell and Molecular Biologists, Veterinarians and Veterinary Researchers, Neuroscientists, Research Clinicians, and Food Scientists

 

Book information

  • Published: August 2013
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-396481-6

Reviews

"The field was in need of this new edition because of the information burst that has occurred with the sequencing of the genome which has led to tractable genetic systems. A one source resource for these molecular techniques is essential to the continuing progress in this research field." – Melanie T. Cushion, Ph.D., Professor and Associate Chair for Research, Division of Infectious Diseases, University of Cincinnati College of Medicine, Ohio




Table of Contents

    Preface
    1. The History and Life Cycle of Toxoplasma gondii
    2. The Ultrastructure of Toxoplasma gondii
    3. Population Structure and Epidemiology of Toxoplasma gondii
    4. Toxoplasma Clinical Disease and Diagnostics
    5. Ocular Disease
    6. Toxoplasmosis in Wild and Domestic Animals
    7. Toxoplasma Animal Models and Therapeutics
    8. Biochemistry, Lipids, Glycobiology and Metabolism of Toxoplasma gondii
    9. The Apicoplast and Mitochondrion of Toxoplasma gondii
    10. Calcium Storage and Homeostasis in Toxoplasma gondii
    11. The Parasitophorous Vacuole: an organelle for the host pathogen interface
    12. Toxoplasma Secretory Organelles: Rhoptries, Micronemes and Dense Granules
    13. The Cytoskelton: Structure and Motility
    14. Alterations in Host Cell Biology due to Toxoplasma gondii
    15. Bradyzoite Development
    16. Development and Application of Classical Genetics in Toxoplasma gondii
    17. Genetic Manipulation
    18. Gene Regulation and Epigenomics
    19. Genomic Analysis and Bioinformatics
    20. Comparative Aspects of Nucleotide and Amino Acid Metabolism in Toxoplasma gondii and other Apicomplexa
    21. Chemical Biology and Toxoplasma as a Model System for Drug Discovery
    22. Proteomics of Toxoplasma gondii
    23. Cerebral Toxoplasmosis: Pathogenesis, Host Resistance and Behavioural Consequences
    24. Innate Immunity in Toxoplasma Infection
    25. Adaptive Immunity and host Genetics
    26. Toxoplasma gondii vaccines
    Epilogue: Toxoplasma as a Model Organism