Tissue-Specific Toxicity

Biochemical Mechanisms

Edited by

  • Wolfgang Dekant, Universitat Wurzburg
  • H. Neumann, Institute of Toxicology and Pharmacology, University of Wadurzburg

This volume provides an up-to-date review of the molecular mechanisms of toxicity. Individual chapters deal with specific aspects of toxicity problems associated with selected organs.
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Audience

Research toxicologists, pharmacologists, oncologists, and physiologists.

 

Book information

  • Published: March 1992
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-208860-5

Reviews

"It is a fitting tribute to a man who spent much of his research career establishing the role of chemical specificity in toxicity."
--ATLA



Table of Contents

D.J. McConkey, T.Y. Aw, and S. Orrenius, Role of the Ca2+-Mediated Endonuclease Activation in Chemical Toxicity. W.N. Aldridge, Selective Neurotoxicity: Problems in Establishing the Relevance of in Vitro data to the in Vivo Situation. J.E. Casida and R.F. Toia, Organophosphorous Pesticides: Their Target Diversities and Bioactivation. U. Andrae and H. Greim, Initiation and Promotion in Thyroid Carcinogenesis. W. Bursch, L. Fesus, and R. Schulte-Hermann, Apoptosis ('Programmed' Cell Death) and its Relevance in Liver Injury and Carcinogenesis. P. Steinberg and F. Oesch, Liver Cell Specific Toxicity of Xenobiotics. H.-G. Neumann, S. Ambs, and W. Hillesheim, The Biochemical Basis of Hepatotoxicity. W. DeKant, S. Vamvakas, and M.W. Anders, The Kidney as a Target Organ for Xenobiotics Bioactivated by Glutathione Conjugation. G.S. Yost, Bioactivation and Selectivity of Pneumotoxic Chemicals. M.E. Scheulen and H. Kappus, Anthracycines as Model Compounds for Cardiac Toxicity. Index.