Tietz Textbook of Clinical Chemistry and Molecular Diagnostics book cover

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics

Bridging the gap between the clinical laboratory and medical management by relating pathophysiology to analytical results in health and disease, this classic resource provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Its up-to-date, encyclopedic coverage of the field defines analytical criteria for the medical usefulness of laboratory procedures, introduces new approaches for establishing reference ranges, describes variables that affect tests and results, examines modern analytical tools and their impact on lab management and costs, and demonstrates the applications of statistical methods.

Book, 2448 Pages

Published: July 2005

Imprint: Saunders

ISBN: 978-1-4557-3412-2


  • Section 1 Laboratory Principles
    1. Introduction to Principles of Laboratory Analyses and Safety
    2. Specimen Collection and Processing

    Section 2 Analytical Techniques and Instrumentation
    3. Optical Techniques
    4. Electrochemistry and Chemical Sensors
    5. Electrophoresis
    6. Chromatography
    7. Mass Spectometry
    8. Principles of Clinical Enzymology
    9. Principles of Immunochemical Techniques
    10. Nanotechnology and Microfabrication
    11. Automation in the Clinical Laboratory
    12. Point-of-Care Testing

    Section 3 Principles of Laboratory Medicine
    13. Introduction to Laboratory Medicine and Evidence-Based Laboratory Medicine
    14. Selection and Analytical Evaluation of Methods—with Statistical Techniques
    15. Clinical Evaluation of Methods
    16. Establishment and Use of Reference Values
    17. Preanalytical Variables and Biological Variation
    18. Clinical Laboratory Informatics
    19. Quality Management

    Section 4 Analytes
    20. Amino Acids, Peptides, and Proteins
    21. Enzymes
    22. Cytokines
    23. Tumor Markers
    24. Kidney Function Tests
    25. Carbohydrates
    26. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors
    27. Electrolytes and Blood Gases
    28. Hormones
    29. Catecholamines and Serotonin
    30. Vitamins and Trace Elements
    31. Hemoglobin, Iron, and Bilirubin
    32. Porphyrins and Disorders of Porphyrin Metabolism
    33. Therapeutic Drugs and Their Management
    34. Clinical Toxicology
    35. Toxic Metals

    Section 5 Molecular Diagnostics and Genetics
    36. Principles of Molecular Biology and Approaches to Nucleic Acid Isolation
    37. Nucleic Acid Techniques
    38. Design and Operation of the Molecular Diagnostics Laboratory
    39. Molecular Genetics and Diagnosis of Hematopoietic Neoplasms
    40. Inherited Diseases
    41. Identity Assessment
    42. Molecular Methods in Diagnosis and Monitoring of Infectious Diseases
    43. Pharmacogenetics

    Section 6 Pathophysiology
    44. Cardiac Function
    45. Kidney Disease
    46. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
    47. Liver Disease
    48. Gastric, Pancreatic, and Intestinal Function
    49. Mineral and Bone Metabolism
    50. Pituitary Function
    51. The Adrenal Cortex
    52. The Thyroid—Pathophysiology and Thyroid Function Testing
    53. Reproductive Related Disorders
    54. Clinical Chemistry of Pregnancy
    55. Inborn Errors of Amino Acid, Organic Acid, and Fatty Acid Metabolism

    Section 7 Appendix
    56. Reference Information for the Clinical Laboratory


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