Tietz Textbook of Clinical Chemistry and Molecular Diagnostics


  • Carl Burtis, PhD, Health Services Division, Oak Ridge National Laboratory, Oak Ridge, TN, and Clinical Professor of Pathology, University of Utah School of Medicine, Salt Lake City, UT
  • Edward Ashwood, MD, Professor of Pathology, University of Utah School of Medicine, and President and CEO, ARUP Laboratories, Salt Lake City, UT
  • David Bruns, MD, Professor of Pathology, University of Virginia School of Medicine, Director of Clinical Chemistry and Associate Director of Molecular Diagnostics, University of Virginia Health System, Charlottesville, VA, and Former Editor, Clinical Chemistry, Washington, DC

Bridging the gap between the clinical laboratory and medical management by relating pathophysiology to analytical results in health and disease, this classic resource provides the guidance necessary to select, perform, and evaluate the results of new and established laboratory tests. Its up-to-date, encyclopedic coverage of the field defines analytical criteria for the medical usefulness of laboratory procedures, introduces new approaches for establishing reference ranges, describes variables that affect tests and results, examines modern analytical tools and their impact on lab management and costs, and demonstrates the applications of statistical methods.
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Book information

  • Published: July 2005
  • Imprint: SAUNDERS
  • ISBN: 978-1-4557-3412-2

Table of Contents

Section 1 Laboratory Principles
1. Introduction to Principles of Laboratory Analyses and Safety
2. Specimen Collection and Processing

Section 2 Analytical Techniques and Instrumentation
3. Optical Techniques
4. Electrochemistry and Chemical Sensors
5. Electrophoresis
6. Chromatography
7. Mass Spectometry
8. Principles of Clinical Enzymology
9. Principles of Immunochemical Techniques
10. Nanotechnology and Microfabrication
11. Automation in the Clinical Laboratory
12. Point-of-Care Testing

Section 3 Principles of Laboratory Medicine
13. Introduction to Laboratory Medicine and Evidence-Based Laboratory Medicine
14. Selection and Analytical Evaluation of Methods—with Statistical Techniques
15. Clinical Evaluation of Methods
16. Establishment and Use of Reference Values
17. Preanalytical Variables and Biological Variation
18. Clinical Laboratory Informatics
19. Quality Management

Section 4 Analytes
20. Amino Acids, Peptides, and Proteins
21. Enzymes
22. Cytokines
23. Tumor Markers
24. Kidney Function Tests
25. Carbohydrates
26. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiovascular Risk Factors
27. Electrolytes and Blood Gases
28. Hormones
29. Catecholamines and Serotonin
30. Vitamins and Trace Elements
31. Hemoglobin, Iron, and Bilirubin
32. Porphyrins and Disorders of Porphyrin Metabolism
33. Therapeutic Drugs and Their Management
34. Clinical Toxicology
35. Toxic Metals

Section 5 Molecular Diagnostics and Genetics
36. Principles of Molecular Biology and Approaches to Nucleic Acid Isolation
37. Nucleic Acid Techniques
38. Design and Operation of the Molecular Diagnostics Laboratory
39. Molecular Genetics and Diagnosis of Hematopoietic Neoplasms
40. Inherited Diseases
41. Identity Assessment
42. Molecular Methods in Diagnosis and Monitoring of Infectious Diseases
43. Pharmacogenetics

Section 6 Pathophysiology
44. Cardiac Function
45. Kidney Disease
46. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
47. Liver Disease
48. Gastric, Pancreatic, and Intestinal Function
49. Mineral and Bone Metabolism
50. Pituitary Function
51. The Adrenal Cortex
52. The Thyroid—Pathophysiology and Thyroid Function Testing
53. Reproductive Related Disorders
54. Clinical Chemistry of Pregnancy
55. Inborn Errors of Amino Acid, Organic Acid, and Fatty Acid Metabolism

Section 7 Appendix
56. Reference Information for the Clinical Laboratory